Biotechnology and Bioinformatics

Dr. Tiratha Raj Singh

Dr. Tiratha Raj Singh
Associate Professor
Faculty In-charge, Media Relations
( 91) 01792-239344
tiratharaj.singh@juit.ac.in
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Biography :

Bioinformatics fascinated me since beginning. Having background in Biology and Computer Science, I selected it as my research career. I did PhD in Bioinformatics from MANIT, Bhopal and joint research work for PhD was also done from Tel-Aviv University, Tel-Aviv, Israel. I worked with Dr. KR Pardasani and Dr. Tal Pupko; their role as supervisor and co-supervisor respectively for my PhD. After completing my PhD in 2008, I won post doctoral fellowship from planning and budgeting committee (VATAT), TAU, Israel. I did my post doctoral studies in Molecular Evolution and Functional Genomics in Dr. Dorothee Huchon's lab. Returning from Israel, I joined DAVV, Indore, India for a year during 2009-10. I joined JUIT in July 2010 and since then I am working on various aspects of Genomics, and Proteomics towards their involvement in various human disease. I am also interested and working on the annotation of complex Biological Networks through Computational Systems Biology approach. I am specifically working on DNA repair mechanisms and their role in malignancies. I am also exploring Alzheimer's Disease (AD) through myriad of computational approaches. 6 PhDs awarded under my guidance and 2 more are pursuing. I had received funding from various government agencies which includes DST, DBT and ICMR. More about me is available at: http://www.bioinfoindia.org/raj  and   http://bit.ly/tiratharaj 

Author Publication Profile:
Book Chapter(s) :
  • Rohit Shikla, Arvind Kumar Yadav, Tiratha Raj Singh (2020). Application of Deep Learning in Biological Big Data Analysis. In Hemraj Saini, Geetanjali Rathee, Dinesh Kumar Saini, Large-Scale Data Streaming, Processing, and Blockchain Security (International, pp. 117 - 148). UK: IGI Global, UK. [ISBN : 9781799834441|] . Google Search
  • Priya P. Panigrahi, Tiratha Raj Singh (2020). Data Mining, Big Data, Data Analytics: Big Data Analytics in Bioinformatics. In , Web Services: Concepts, Methodologies, Tools, and Applications (pp. ). USA: IGI Global, USA. [ISBN : 9781522575016] . Google Search
  • Manika Sehgal, Tiratha Raj Singh (2020). Principles and Analysis of Biological Networks: Biological Pathways and Network Motifs. . In , Data Analytics in Medicine: Concepts, Methodologies, Tools, and Applications (pp. 551-564). USA: IGI Blobal. [ISBN : ISBN13: 9781799812043] . Google Search
  • Ankush Bansal, Tiratha Raj Singh (2019). Epigenome Wide DNA Methylation and Histone Modification of Alzheimers Disease. In , Computational Epigenetics and Diseases (pp. 131-148). : Academic Press. [ISBN : ] . Google Search
  • Ankush Bansal, Siddhant Kalra, Babajan Banaganapalli, Tiratha Raj Singh (2019). Modeling and Optimization of Molecular Biosystems to Generate Predictive Models. In Noor Ahmad Shaik, Khalid Rehman Hakeem, Babajan Banaganapalli, Ramu Elango, Essentials of Bioinformatics, Volume I: understanding bioinformatics: genes to proteins (pp. 373-387). Switzerland : Springer, Cham. [ISBN : 978-3-030-02634-9] . Google Search
  • Tiratha Raj Singh, Ankush Bansal (2018). Phylogenetic Analysis: Gene Duplication and Speciation. In Shoba Ranganathan, Kenta Nakai, Christian Schonbach, Reference Module in Life Sciences (Encyclopedia of Bioinformatics and Computational Biology, pp. ). : Elsevier. [ISBN : 9780128114148] . Google Search
  • Tiratha Raj Singh, Ankita Shukla, Bensellak Taoufik, Ahmed Moussa, Brigitte Vannier (2018). Metabolome Analysis: Disease Biomarker Discovery. In Shoba Ranganathan, Kenta Nakai, Christian Schonbach, Reference Module in Life Sciences (Encyclopedia of Bioinformatics and Computational Biology, pp. ). : Elsevier. [ISBN : 9780128114148] . Google Search
  • Ankush Bansal, Mehul Salaria, Tiratha Raj Singh (2018). Tau Pathology: A Step Towards Understanding Neurodegenerative Disorders Network Complexity . In , Handbook of Research on Critical Examinations of Neurodegenerative Disorders (pp. 217-234). : IGI Global. [ISBN : ] . Google Search
  • Ankita Shukla, Tiratha Raj Singh (2017). Computational Network Approaches and their Applications for Complex Diseases. In Dong-Qing Wei, Yilong Ma, William C.S. Cho, Qin Xu, Fengfeng Zhou, Translational Bioinformatics and Its Application (International, pp. 337-352). Netherlands: Springer Netherlands. [ISBN : 9789402410433] . Google Search
  • Manika Sehgal, Tiratha Raj Singh (2017). Principles and Analysis of Biological Networks: Biological Pathways and Network Motifs. In , Library and Information Services for Bioinformatics Education and Research (pp. 112-129). : IGI Global. [ISBN : 9781522518716] . Google Search
  • Priya P Panigrahi, Tiratha Raj Singh (2017). Data Mining, Big Data, Data Analytics: Big Data Analytics in Bioinformatics. In , Library and Information Services for Bioinformatics Education and Research (pp. 91-111). : IGI Global. [ISBN : 9781522518716] . Google Search
  • Tiratha Raj Singh, Brigitte Vannier, Ahmed Moussa (2016). Extraction of Differentially Expressed Genes in Microarray Data. In Mourad Elloumi, Costas S. Iliopoulos, Jason T. L. Wang and Albert Y. Zomaya, Pattern Recognitin in Computational Molecular Biology: TECHNIQUES AND APPROACHES (International, pp. 335-345). : Wiley. [ISBN : 978-1-118-89368-5] . Google Search
  • Tiratha Raj Singh (2015). Mitogenomics: Mitochondrial Gene Rearrangements, its Implications and Applications. In R. Keshavchandran, S. Raji Radhakrishnan, Agriculture Bioinformatics (pp. 259-69). New Delhi: New India Publishing Agency. [ISBN : 9789383305421] . Google Search
  • Tiratha Raj Singh (2014). Machine Learning with Special Emphasis on Support Vector Machines (SVMs) in Systems Biology: A Plant Perspective. In Kavi Kishor, Rajib Bandopadhyay, Prashanth Suravajhala, Agricultural Bioinformatics (pp. 273-281). New Delhi: Springer India. [ISBN : 978-81-322-1879-1] . Google Search
Journal(s) :
Conference(s) :
  • Siddhant Kalra, Tiratha Raj Singh (2019). MAD: a system level computational enrichment analysis of mitochondria associated genes in Alzheimers disease. Proceedings of the International Conference on Recent Trend in Biotechnology and Bioinformatics (ICBAB- 2019), [JUIT Waknaghat, Solan, India : 01-03, August 2019], pp.-.. Google Citation
  • Chadia Ed-driouch, Tiratha Raj Singh, Ahmed Moussa (2019). Transcriptomics Data: Study on Gene Selection Methods. Proceedings of the International Conference on Recent Trend in Biotechnology and Bioinformatics (ICBAB- 2019) [JUIT Waknaghat : 01-03 August 2019], pp.-.. Google Citation
  • Rohit Shukla, Narendra Kumar, Tiratha Raj Singh (2019). Disruption of plaques and tangles formation by targeting multiple enzymes using polypharmacology approach. Proceedings of the National Biomedical Research Competition (NBRCom-2019) [2nd : PGIMER, Chandigarh : 17th Nov., 2019], pp.32-.. Google Citation
  • Tiratha Raj Singh (2019). Docking studies of Paclitaxel and Paclitaxel prodrgs with CYP enzymes to correlate solubility and bioavailability. Proceedings of the Indian Conference on Bioinformatics (Inbix), 2019 [HMV, Jalandhar, India : Feb., 22-23, 2019], pp.-.. Google Citation
  • Ankush Bansal, Shweta Parmar, Shorya Singh, Rohit Shukla, Tiratha Raj Singh (2018). Big data analytics inference for precision medicine to decipher regulatory interactions in lung cancer. Proceedings of the Himachal Pradesh Science Congress (HPSC) 2018 [3rd : Indian Institute of Technology (IIT) Mandi, Himachal Pradesh, India : Oct., 22-23, 2018], pp.-.. Google Citation
  • Sadhika Behl, Arushi Sharma, Tiratha Raj Singh (2017). Computational analysis of expression and interaction data to reveal role of DNA Mismatch Repair in MSI and HNPCC. Proceedings of the Inbix 17: Indian Conference on Bioinformatics 2017 [Birla Institute of Scientific Research, Jaipur, India : Nov. 7-9, 2017], pp.-.. Google Citation
  • Siddhant Kalra, Ankush Bansal, Tiratha Raj Singh (2017). Computational enrichment of Alzheimer associated human mitochondrial genes using comparative expression analysis approach. Proceedings of the Inbix 17: Indian Conference on Bioinformatics 2017 [Birla Institute of Scientific Research, Jaipur : Nov. 7-9, 2017], pp.-.. Google Citation
  • Ankita Shukla, Ragothaman M. Yennamalli, Tiratha Raj Singh (2017). Structure Based Inference of Functional Single Nucleotide Polymorphism L28F and to Determine its Role in TGFbeta1 Allied Colorectal Cancer (CRC). Proceedings of the Inbix 17: Indian Conference on Bioinformatics 2017 [Birla Institute of Scientific Research, Jaipur : Nov. 7-9, 2017], pp.-.. Google Citation
  • Ankush Bansal, Anil Kant Thakur, Tiratha Raj Singh (2017). A network analysis framework to decipher uni-directional information flow from differential transcriptome datasets for pathway of interest. Proceedings of the Indian Conference on Bioinformatics (Inbix’17) [Birla Institute of Scientific Research, Jaipur : Nov. 7-9, 2017], pp.-.. Google Citation
  • Ashwani kumar, Tiratha Raj Singh (2016). System Biology Approach for Gene Set Enrichment and Topological Analysis of AD. Proceedings of the International Conference on Bioinformatics and Systems biology(BSB)-2016 [IIIT-A, Allahabad, India : 4 - 6 March, 2016], pp.-.. Google Citation
  • Vineet Mehta, Ashwani Kumar, Tiratha Raj Singh, Udayabanu M (2015). Screening of herbal molecules against type 2 diabetes mediated memory dysfunction. Proceedings of the Annual Conference of Indian Academy of neurosciences (IAN)-2015 [Panjab University, Chandigarh, India : Oct., 31-Nov., 02, 2015], pp.36-37-.. Google Citation
  • Ashwani Kumar, Utkarsh Raj, Pritish Kumar Varadwaj, Tiratha Raj Singh (2015). Flexible docking and simulation studies of herbal compounds as Acetylcholinesterase inhibitor(AChEI) for Alzheimers disease. Proceedings of the National Conference on Bioinformatics Panorama in Agriculture and Health [SHIATS, Allahabad, India : 5-6 October 2015], pp.-.. Google Citation
  • Ashwani kumar, Vineet mehta, Utkarsh Raj, Pritish Kr. Varadwaj, Udayabanu M, Tiratha Raj Singh (2015). Insights From Docking And Molecular Dynamic Simulation of Acetyl cholinesterase Inhibitors (AChEI) Structural Model For Possible Therapeutic Of Alzheimers Disease(AD) . Proceedings of the Annual Conference of Indian Academy of neurosciences (IAN)-2015, [Panjab University, Chandigarh, India : October 31 - November 2, 2015 ], pp.-.. Google Citation
  • Ankita Shukla, Ashwani Kumar, Manika Sehgal, Tiratha Raj Singh (2015). Modeling and Simulation of Colorectal Cancer Pathways : An Insight into Regulatory Elements and Biological Processes. Proceedings of the Annual International Conference on Advances in Biotechnology [5th : Kanpur, India : 13-15 March 2015], pp.85-89.. Google Citation
  • Manika Sehgal, Tiratha Raj Singh (2014). Bioinformatics applications to resolve the mystery of diseases associated with Human DNA repair system. Proceedings of the Annual Conference of Indian Association of Biomedical Scientists [35 : Palampur, India : 14-16 July 2014], pp.39-41.. Google Citation
  • Ankita Shukla, Manika Sehgal, Tiratha Raj Singh (2014). Hydroxymethylation and its Role in DNA Repair Associated Disease. Proceedings of the International Conference on Life Sciences, Informatics, Food and Environment [Noida, India : 29-30, August 2014], pp.-.. Google Citation
  • Manika Sehgal, Ankita Shukla, Tiratha Raj Singh (2014). Functional Enrichment of Pathways Implicated in DNA Repair using Top Down Approach. Proceedings of the International Conference on Life Sciences, Informatics, Food and Environment [Noida, India : 29-30, August 2014], pp.180-.. Google Citation
  • Manika Sehgal, Tiratha Raj Singh (2014). Computational Approach for the Identification of Plausible Biomarkers from Composite Networks and Gene Expression data Associated with Colorectal Cancer. Proceedings of the World Congress on Stem Cell Research, Cancer Biology and Applied Biotechnology [New Delhi, India : 3-4, May 2014], pp.140-.. Google Citation
  • Ashwani kumar, Abhay Pratap, Urvashi, Rajinder S. Chauhan, Tiratha Raj Singh (2013). SMDB: Soybean Marker Database. Proceedings of the IFIP International Conference of Bioinformatics [3rd : Bhopal, India : 23-26 September, 2013], pp.99-101.. Google Citation
  • Gurnoor Singh, Tanya Singhania, Arun Gupta, Tiratha Raj Singh (2013). SHIFTDB: database of hidden stop codons in frame-shifted translation in mitochondrial genomic sequences. Proceedings of the Joint 21st Annual International Conference on Intelligent Systems for Molecular Biology (ISMB) and 12th European Conference on Computational Biology (ECCB) 2013 [21 : Berlin, Germany : 21-23, July, 2013], pp.-.. Google Citation
  • Ankit Gupta, Gautam Mehta, Priya P. Panigrahi, Ahmed Moussa, Tiratha Raj Singh (2013). MiND: web repository for Mitochondrial and Neurological associated human Disease. Proceedings of the SCB Africa ASCBC Conference [Morocco : 13-15 March 2013], pp.-.. Google Citation
  • Manika Sehgal, Tiratha Raj Singh (2013). Quantitative Genetic Analysis of DNA Repair Genes Implicated in Xeroderma Pigmentosum. Proceedings of the International Federation for Information Processing (IFIP), International Conference on Bioinformatics [3rd : Bhopal, India : 23-26 September 2013], pp.31-32.. Google Citation
  • Ramesh Katam, Devaiah M. Kambiranda, Katsumi Sakata, Tiratha Raj Singh, Steve V. Sluyter, Paul A. Haynes, Mehboob B. Sheikh, Lekan M. Latinwo (2013). Characterization of Muscadine Berry Proteome Using Label and Label Free Mass Spectrometry Approaches (Poster). Proceedings of the HUPO Annual World Congress [12th : Yokohama, Japan : 14-18 September, 2013], pp.PS33-PS36.. Google Citation
  • Digvijay Singh Chauhan, Das A., Panigrahi P.P., Tiratha Raj Singh (2012). Development of early phase diagnostics for Alzheimers disease: use of diabetes mellitus as surrogate biomarker. Proceedings of the InCoB [Thailand, Bangkok : 3-5 October 2012], pp.-.. Google Citation
  • Digvijay Singh Chauhan, Tiratha Raj Singh (2012). Chaos as positive and negative adaptation (Abstract). Proceedings of the InCoB [Thailand, Bangkok : 3-5 October 2012], pp.-.. Google Citation
  • Manika Sehgal, Tiratha Raj Singh (2011). Identification and analysis of biomarkers for mismatch repair proteins: A bioinformatic approach. Proceedings of the The International Interdisciplinary Science Conference on Bioinformatics: An interface between Computer Science and Biology [New Delhi, INDIA : 15-17, November 2011], pp.38-39.. Google Citation
  • Singhania T., Singh G., Gupta A., Tiratha Raj Singh (2011). DoMoS: Domain and Motif Server for Functional Information. Proceedings of the IFIP International Conference [IInd : Goa : Sept. 22-25], pp.-.. Google Citation
  • Bhargava P., Gupta M. Gupta A., Tiratha Raj Singh (2011). WebGenPro: a Web Server for Genomic and Proteomic Analysis. Proceedings of the IFIP International Conference [IInd : Goa : Sept. 22-25], pp.-.. Google Citation
  • Priya P.P., Tiratha Raj Singh (2011). Functional annotation of Alzheimers related proteins through protein-protein interactions and other in silico methods. Proceedings of the IFIP International Conference [2 : Goa : Sept. 22-25], pp.-.. Google Citation
Abstract/ Poster Presentations/ Invited Lectures in Conferences :
  • Ankita Shukla, Raghu M. Yennamalli , Tiratha Raj Singh (2017). Structure Based Inference of Functional Single Nucleotide Polymorphism “L28F” and to Determine its Role in TGFβ1 Allied Colorectal Cancer (CRC). Proceedings of the Indian Conference on Bioinformatics 2017 [Jaipur : 7-9 November], pp.35-37.. Google Citation
  • Jain S, Tiratha Raj Singh, Jitendraa Vashistt, Harish Changotra (2015). Molecular analysis of G1 rotavirus strains isolated from Himachal Pradesh. Proceedings of the National Conference on Emerging Trends in Host-Microb Interactions [Jalandhar, Punjab : 17-18 April 2015], pp.-.. Google Citation
  • Manika Sehgal, Tiratha Raj Singh (2014). Decoding the intricate biological pathways for biomarkers implicated in Human DNA repair system. Proceedings of the Recent Advances in Biological Sciences [New Delhi, India : 10th December 2014], pp.-.. Google Citation
  • R. Randhawa, M. Sehgal, Tiratha Raj Singh, A. Duseja, Harish Changotra (2014). Computational analysis of unc-51 like kinase 1 (ULK1) gene and its association with autophagy. Proceedings of the International Conference on “Stem Cell Research, Cancer Biology, Biomedical Sciences, Bioinformatics and Applied Biotechnology [New Delhi, India : 1 -2 November 2014], pp.106-.. Google Citation
  • Ira Vashisht, Sreekrishna Chanumolu, Tarun Pal, Prashant Mishra, Tiratha Raj Singh, Rajinder S. Chauhan (2013). Deciphering the Role of miRNAs in Regulating Growth, Development and Secondary Metabolites Production in an Endangered Medicinal Herb, Picrorhiza kurroa. Proceedings of the Annual Convention of ABAP & International Conference on Plant Biotechnology, Molecular Medicine & Human Health [7th : New Delhi, India : 18-20 October, 2013], pp.232-233.. Google Citation