Biotechnology and Bioinformatics

Dr. Jata Shankar
Associate Professor
(91)01792-239225
jata.shankar@juit.ac.in, jata_s@yahoo.com
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Biography :

M. Sc. (Through JNU, Delhi, Combined Test) from Calicut University, Calicut, Kerala (1999-2001).
Ph. D. from Institute of Genomics and Integrative Biology-IGIB, (CSIR) and Jamia Millia Islamia-Central University, New Delhi (2001-2006).
Post-doctoral Research Scholar (2007-2012) at Division of Infectious Diseases and Geographic Medicine School of Medicine Stanford University and California Institute for Medical Research, California, USA.
Assistant Professor (Regular appointment), Department of Biotechnology GGV-Central University, Bilaspur (C.G.) India (2012- 2013).
Associate Professor, Department of Biotechnology and Bioinformatics, Jaypee University of Information Technology, Solan, Himanchal Pradesh (Present).
Currently working on Aspergillus-host interaction using genomic approaches, role hormone on fungal pathogenesis and secondary metabolite products.

Field(s) of Specialization:
Molecular Biology of Fungi,
Functional Genomics of Microbes (Infectious agents),
Structural and functional analysis of proteins,
Impact of mycotoxin on health

Major Project Research Area:
1. Occurrence and screening of fungal pathogens associated with main crops of Himachal Pradesh
2. In Silico study pf phytochemicals to study the interaction of covid 19 protein with drugs, vitamins, etc
3. Impact of SNPs on Cancer cells
4. Role of gut mycobiome at the interface of human health
5. Impact of mycotoxin on health

Publication(s):
2022 (1)	2021 (1)	2020 (9)	2019 (3)	2018 (4)	2017 (8)
2016 (5)	2015 (4)	All

Book Chapter(s) :

Shraddha Tiwari, Jata Shankar (2018). Hsp70 in Fungi: Evolution, Function and Vaccine Candidate. In Dr. Alexzander A. A. Asea & Dr. Punit Kaur, HSP70 in Human Diseases and Disorders (14, pp. 381-400). Springer International Publishing AG, part of Springer Nature: Springer, Cham. [ISBN : 978-3-319-89550-5] . Google Search
Ankita Srivastava, Saurabh Bansal, Jata Shankar (2017). Developments and Diversity of Proteins and Enzymes. In Vipin Chandra Kalia, Adesh Kumar Saini, Strategies for Metabolic Engineering in Bioactive Compounds and Processes (pp. 11-48). Singapore: Springer. [ISBN : 9789811055119] . Google Search
Srivastava A., Bansal S., Jata Shankar (2017). Developments and Diversity of Proteins and Enzymes. In Kalia V., Saini A., Metabolic Engineering for Bioactive Compounds (pp. 11-48). Singapore: Springer. [ISBN : 9789811055119] . Google Search
Thakur R., Jata Shankar (2017). Strategies for Gene Expression in Prokaryotic and Eukaryotic System. In Kalia V., Saini A., Metabolic Engineering for Bioactive Compounds (pp. 223-247). Singapore: Springer. [ISBN : 9789811055119] . Google Search

Journal(s) :

Jata Shankar (2022). Insight into the metabolic changes during germination of Aspergillus niger conidia using nLC-qTOF. Biologia, (), 1-14
Jata Shankar (2021). Food Habit Associated Mycobiota Composition and Their Impact on Human Health. Frontiers in Nutrition, 8 (773577), 1-6. Google Citation
Komal Agrawal, Jata Shankar, Pradeep Verma (2020). Multicopper oxidase (MCO) laccase from Stropharia sp. ITCC-8422: an apparent authentication using integrated experimental and in silico analysis. 3 Biotech, 10 (413), 1-18
Komal Agrawal, Jata Shankar, Raj Kumar, Pradeep Verma (2020). Insight into multicopper oxidase laccase from Myrothecium verrucaria ITCC-8447: a case study using in silico and experimental analysis. Journal of Environmental Science and Health - Part B Pesticides, Food Contaminants, and Agricultural Wastes, 55 (12), 1048-1060. Google Citation
Shanu Hoda, Lovely Gupta, Jata Shankar, Alok Kumar Gupta, Pooja Vijayaraghavan (2020). cis-9-Hexadecenal, a Natural Compound Targeting Cell Wall Organization, Critical Growth Factor, and Virulence of Aspergillus fumigatus. ACS Omega, 5 (17), 10077-10088
Manali Gangwar, Jata Shankar (2020). Molecular mechanisms of floral biology of Jatropha curcas: opportunities and challenges as an energy crop. Frontiers in Plant Science , 11 (609), 1-9. Google Citation
Sonia K Shishodia, Jata Shankar (2020). Proteomic analysis revealed ROS-mediated growth inhibition of Aspergillus terreus by shikonin. Journal of Proteomics, 224 (103849), 1-12. Google Citation
Shanu Hoda, Maansi Vermani, Rajesh K. Joshi, Jata Shankar, Pooja Vijayaraghavan (2020). Anti-melanogenic activity of Myristica fragrans extract against Aspergillus fumigatus using phenotypic based screening. BMC Complementary Medicine and Therapies, 20 (67), 1-13
Sonia K. Shishodia, Shraddha Tiwari, Shanu Hoda, Pooja Vijayaraghavan, Jata Shankar (2020). SEM and qRT-PCR revealed quercetin inhibits morphogenesis of Aspergillus flavus conidia via modulating calcineurin-Crz1 signalling pathway. Mycology, 11 (2), 118-125
Sonia Kumari Shishodia, Jata Shankar (2020). Exploration of Mycelial Proteins from Aspergillus terreus Revealed Ribosome Biogenesis and Antioxidant Enzymes. Current Proteomics, 17 (5), 433-445. Google Citation
Sonia K. Shishodia, Shraddha Tiwari, Jata Shankar (2019). Resistance mechanism and proteins in Aspergillus species against antifungal agents. Mycology, 10 (Feb 2019), 1-14
Shraddha Tiwari, Sonia K. Shishodia, Jata Shankar (2019). Docking analysis of hexanoic acid and quercetin with seven domains of polyketide synthase A provided insight into quercetin-mediated aflatoxin biosynthesis inhibition in Aspergillus flavus. 3 Biotech, 9 (4), 1-12
Raman Thakur, Jata Shankar (2019). Proteome Analysis Revealed Jak/Stat Signaling and Cytoskeleton Rearrangement Proteins in Human Lung Epithelial Cells During Interaction with Aspergillus terreus. Current Signal Transduction Therapy , 14 (1), 55-67. Google Citation
Jata Shankar, Gustavo C Cerqueira, Jennifer R Wortman, Karl V Clemons, David A Stevens (2018). RNA-Seq Profile Reveals Th-1 and Th-17-Type of Immune Responses in Mice Infected Systemically with Aspergillus fumigatus. Mycopathologia, 183 (4), 645-658
Jata Shankar, Shraddha Tiwari, Sonia Shishodia, Manali Gangwar, Shanu Hoda, Raman Thakur, Pooja Vijayaraghavan (2018). Molecular insights into development and virulence determinants of Aspergilli: A proteomic perspective. Frontiers in Cellular and Infection Microbiology, 8 (180), 1-15
Shraddha Tiwari, Jata Shankar (2018). Integrated proteome and HPLC analysis revealed quercetin-mediated inhibition of aflatoxin B1 biosynthesis in Aspergillus flavus. 3 Biotech, 8 (1), -
Raman Thakur, Jata Shankar (2017). Comprehensive in-silico Analysis of High-risk Non-synonymous SNPs in Dectin-1 Gene of Human and their Impact on Protein Structure. Current Pharmacogenomics and Personalized Medicine, 15 (2), 144-155
Shraddha Tiwari, Nupur Gupta, Udayabanu M, Jata Shankar (2017). Anti-aspergillus properties of phytochemicals against aflatoxin producing Aspergillus flavus and Aspergillus parasiticus. National Academy Science Letters, 40 (2017), 267-271
Raman Thakur, Jata Shankar (2017). Proteome Profile of Aspergillus terreus Conidia at Germinating Stage: Identification of Probable Virulent Factors and Enzymes from Mycotoxin Pathways. Mycopathologia, 182 (9-10), 771-784
Raman Thakur, Jata Shankar (2017). New Treatment Regime for Aspergillus Mediated Infections. Virology & Mycology, 6 (1), -
Raman Thakur, Jata Shankar (2016). In silico Identification of Potential Peptides or Allergen Shot Candidates Against Aspergillus fumigatus . BioResearch Open Access, 5 (1), 330-341
Shraddha Tiwari, Raman Thakur, Gunjan Goel, Jata Shankar (2016). Nano-LC-Q-TOF Analysis of Proteome Revealed Germination of Aspergillus flavus Conidia is Accompanied by MAPK Signalling and Cell Wall Modulation. Mycopathologia, (), 1-18
Raman Thakur, Jata Shankar (2016). In silico Analysis Revealed High-risk Single Nucleotide Polymorphisms in Human Pentraxin-3 Gene and their Impact on Innate Immune Response against Microbial Pathogens. Frontiers in microbiology, 7 (192), 1-12. Google Citation
Raman Thakur, Shraddha Tiwari, Jata Shankar (2016). Differential Expression Pattern of Heat Shock Protein Genes in Toxigenic and Atoxigenic Isolate of Aspergillus flavus. British Microbiology Research Journal, 14 (2), 1-9
Shraddha Tiwari, Raman Thakur, Jata Shankar (2015). Role of Heat-Shock Proteins in Cellular Function and in the Biology of Fungi. Biotechnology Research International, 2015 (2015), 1-11. Google Citation
Raman Thakur, Rajesh Anand, Shraddha Tiwari, Agam P. Singh, Bhupendra N. Tiwary, Jata Shankar (2015). Cytokines induce effector T-helper cells during invasive aspergillosis; what we have learned about T-helper cells?. Frontiers in microbiology, 6 (429), -. Google Citation
R. Anand, Jata Shankar, B.N. Tiwary, A.P. Singh (2015). Aspergillus flavus induces granulomatous cerebral aspergillosis in mice with display of distinct cytokine profile. Cytokine, 72 (2), 166-172. Google Citation
Tarun Kumar Patel, Rajesh Anand, Agam Prasad Singh, Jata Shankar, Bhupendra N. Tiwary (2015). Evaluation of aflatoxin B1 biosynthesis in A. flavus isolates from central india and identification of atoxigenic isolates. Biotechnology and Bioprocess Engineering, 19 (6), 1105-1113. Google Citation

Conference(s) :

Jata Shankar, Raman Thakur, Shanu Hoda, Shraddha Tiwari, Pooja Vijayaraghavan (2017). Proteome profile provided molecular insight into germination of Aspergilli and biosynthesis of secondary metabolites. Proceedings of the International Congress on Analytical Proteomics (V ICAP 2017) [5th : Caparica, Portugal. : 3-6 July, 2017 ], pp.-.. Google Citation
Shraddha Tiwari, Raman Thakur, Gunjan Goel, Jata Shankar (2016). Identification and Functional categorization of Protein Involved in Germination of Aspergillus Flavus Conidia. Proceedings of the Advances Against Aspergillosis [7th : Manchester University, Manchester UK : 3-5 March, 2016], pp.-.. Google Citation

Abstract/ Poster Presentations/ Invited Lectures in Conferences :

Raman, Jata Shankar (2015). Heat-shock proteins influence Aflatoxin biosynthesis in Aspergillus flavus . Proceedings of the Emerging Trends in Host-Microbe Interactions [Jalandhar, India : April 17-18, 2015], pp.-.. Google Citation
Tarun Kumar Patel, Jata Shankar, Bhupendra N Tiwary (2014). Mosquito larvicidal potential of Aspergillus flavus against Culex quinquefasciatus and Aedes aegypti. Proceedings of the National Conference on Empowering Mankind with Microbial Technologies [55th : Tamil Nadu Agricultural University Coimbatore - 641 003 : Nov 12-14, 2014], pp.-.. Google Citation

Biotechnology and Bioinformatics

FACULTY NAMES