Biotechnology and Bioinformatics

Prof. Dr. Jata Shankar
Professor
(91)01792-239225
jata.shankar@juit.ac.in, jata_s@yahoo.com
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Biography :

M. Sc. (Through JNU, Delhi, Combined Test) from Calicut University, Calicut, Kerala (1999-2001).
Ph. D. from Institute of Genomics and Integrative Biology-IGIB, (CSIR) and Jamia Millia Islamia-Central University, New Delhi (2001-2006).
Post-doctoral Research Scholar (2007-2012) at the Division of Infectious Diseases and Geographic Medicine School of Medicine Stanford University and California Institute for Medical Research, California, USA.
Assistant Professor (Regular appointment), Department of Biotechnology GGV-Central University, Bilaspur (C.G.) India (2012- 2013).
Assistant Professor, Department of Biotechnology and Bioinformatics, Jaypee University of Information Technology, Solan, Himachal Pradesh (July 2013-2017).
Associate Professor, Department of Biotechnology and Bioinformatics, Jaypee University of Information Technology, Solan, Himachal Pradesh (2018-2022).
Professor, Department of Biotechnology and Bioinformatics, Jaypee University of Information Technology, Solan, Himachal Pradesh (Present).
Currently working on Aspergillus-host interaction using genomic and proteomics, Antifungal molecules, Cell bound and soluble receptors, Aflatoxin pathway, Shikonin

Field(s) of Specialization:
Molecular Biology of Fungi,
Functional Genomics of Microbes (Infectious agents),
Structural and functional analysis of proteins,
Impact of mycotoxin on health

Major Project Research Area:
1. Occurrence and screening of fungal pathogens associated with main crops of Himachal Pradesh
2. In Silico study pf phytochemicals to study the interaction of covid 19 protein with drugs, vitamins, etc
3. Impact of SNPs on Cancer cells
4. Role of gut mycobiome at the interface of human health
5. Impact of mycotoxin on health

Author Publication Profile:

Publication(s): Click Here to Add New Publication(s)
2023 (5)	2022 (2)	2021 (1)	2020 (9)	2019 (3)	2018 (4)
2017 (7)	2016 (5)	2015 (4)	All

Book Chapter(s) :

Aanchal Bansal, Megha Sharma, Aakanksha Pandey, Jata Shankar (2023). Aflatoxins: Occurrence, Biosynthetic Pathway, Management and Impact on Health. In Fungal Resources for Sustainable Economy pp. 565-594 Singapore Pvt Ltd: Springer Nature. [ISBN : 978-981-19-9102-8 ] [SCOPUS ]. Google Search
Chhavi Thakur, Jata Shankar (2022). Bioinformatics Integration to Biomass Waste Biodegradation and Valorization. In Enzymes in the Valorization of Waste 1st, pp. 177-203 Boca Raton: CRC Press. [ISBN : 9781003187721] []. Google Search
Shraddha Tiwari, Jata Shankar (2018). Hsp70 in Fungi: Evolution, Function and Vaccine Candidate. In HSP70 in Human Diseases and Disorders 14, pp. 381-400 Switzerland: Springer. [ISBN : 978-3-319-89550-5] [SCOPUS ]. Google Search
Ankita Srivastava, Saurabh Bansal, Jata Shankar (2017). Developments and Diversity of Proteins and Enzymes. In Strategies for Metabolic Engineering in Bioactive Compounds and Processes pp. 11-48 Singapore: Springer. [ISBN : 9789811055119] []. Google Search
Thakur R., Jata Shankar (2017). Strategies for Gene Expression in Prokaryotic and Eukaryotic System. In Metabolic Engineering for Bioactive Compounds pp. 223-247 Singapore: Springer. [ISBN : 9789811055119] []. Google Search

Journal(s) :

Megha Rani, Swastik Manibhushan Mondal, Purba Kundu, Anuja Thakur, Abhishek Chaudhary, Jitendraa Vashistt, Jata Shankar (2023). Edible Mushroom: Occurrence, Management and Health Benefits. Food Materials Research, 3 (21), pp. 1-9, DOI: https://doi.org/10.48130/FMR-2023-0021 []. Google Citation
Tulika Srivastava, Divya Tyagi, Siraj Fatima, Malur Thirumalesh Vishnu Sathyan, Ritu Raj, Aniket Sharma, Minal Chaturvedi, Meetali Sinha, Sonia Kumari Shishodia, Dinesh Kumar, Sandeep K. Sharma, Jata Shankar, Aruna Satish, Smriti Priya (2023). A natural small molecule-mediated inhibition of alpha-synuclein aggregation leads to neuroprotection in Caenorhabditis elegans. Journal of Neurochemistry, x (x), pp. 1-15, DOI: https://doi.org/10.1111/jnc.15907 [SCOPUS , SCI , UGC Care ]. Google Citation
Pooja Sen, Lovely Gupta, Mukund Vijay, Maansi Vermani Sarin, Jata Shankar, Saif Hameed, Pooja Vijayaraghavan (2023). 4-Allyl-2-methoxyphenol Modulates the Expression of Genes Involved in Efflux Pump, Biofilm Formation and Sterol Biosynthesis in Azole Resistant Aspergillus fumigatus. Frontiers in Cellular and Infection Microbiology, 13 (2023), pp. 1-12, DOI: doi: 10.3389/fcimb.2023.1103957 [SCOPUS , SCI , UGC Care ]. Google Citation
Chhavi Thakur, Amanjot Singh Malhotra, Jata Shankar (2023). Integrated Bioinformatics Analysis to Study Gallic Acid-Mediated Inhibition of Polyketide Synthase A from Aflatoxin Biosynthesis Pathway of Aspergillus flavus. Chemistry Africa , 6 (2023), pp. 1-16, DOI: https://doi.org/10.1007/s42250-023-00589-4 [SCOPUS , UGC Care ]. Google Citation
Jata Shankar (2022). Insight into the metabolic changes during germination of Aspergillus niger conidia using nLC-qTOF. Biologia, 77 (2022), pp. 2701-2714, DOI: 10.1007/s11756-022-01115-6 [SCOPUS , SCI ]. Google Citation
Jata Shankar (2021). Food Habit Associated Mycobiota Composition and Their Impact on Human Health. Frontiers in Nutrition, 8 (773577), pp. 1-, DOI: https://doi.org/10.3389/fnut.2021.773577 [SCOPUS , SCI ]. Google Citation
Komal Agrawal, Jata Shankar, Pradeep Verma (2020). Multicopper oxidase (MCO) laccase from Stropharia sp. ITCC-8422: an apparent authentication using integrated experimental and in silico analysis. 3 Biotech, 2020 (10), pp. 1-18, DOI: https://link.springer.com/article/10.1007/s13205-020-02399-8 [SCOPUS , SCI ]. Google Citation
Komal Agrawal, Jata Shankar, Raj Kumar, Pradeep Verma (2020). Insight into multicopper oxidase laccase from Myrothecium verrucaria ITCC-8447: a case study using in silico and experimental analysis. Journal of Environmental Science and Health - Part B Pesticides, Food Contaminants, and Agricultural Wastes, 55 (12), pp. 1-18, DOI: https://doi.org/10.1080/03601234.2020.1812334 [SCOPUS , SCI ]. Google Citation
Shanu Hoda, Lovely Gupta, Jata Shankar, Alok Kumar Gupta, Pooja Vijayaraghavan (2020). cis-9-Hexadecenal, a Natural Compound Targeting Cell Wall Organization, Critical Growth Factor, and Virulence of Aspergillus fumigatus. ACS Omega, 5 (17), pp. 10077-10088, DOI: https://doi.org/10.1021/acsomega.0c00615 [SCOPUS , SCI ]. Google Citation
Manali Gangwar, Jata Shankar (2020). Molecular mechanisms of floral biology of Jatropha curcas: opportunities and challenges as an energy crop. Frontiers in Plant Science , 11 (609), pp. 1-, DOI: https://doi.org/10.3389/fpls.2020.00609 [SCOPUS , SCI ]. Google Citation
Sonia K Shishodia, Jata Shankar (2020). Proteomic analysis revealed ROS-mediated growth inhibition of Aspergillus terreus by shikonin. Journal of Proteomics, 224 (103849), pp. 1-12, DOI: https://doi.org/10.1016/j.jprot.2020.103849 [SCOPUS , SCI ]. Google Citation
Shanu Hoda, Maansi Vermani, Rajesh K. Joshi, Jata Shankar, Pooja Vijayaraghavan (2020). Anti-melanogenic activity of Myristica fragrans extract against Aspergillus fumigatus using phenotypic based screening. BMC Complementary Medicine and Therapies, 20 (67), pp. 1-13, DOI: https://doi.org/10.1186/s12906-020-2859-z [SCOPUS , SCI ]. Google Citation
Sonia K. Shishodia, Shraddha Tiwari, Shanu Hoda, Pooja Vijayaraghavan, Jata Shankar (2020). SEM and qRT-PCR revealed quercetin inhibits morphogenesis of Aspergillus flavus conidia via modulating calcineurin-Crz1 signalling pathway. Mycology: An International Journal on Fungal Biology, 11 (2), pp. 118-125, DOI: https://doi.org/10.1080/21501203.2020.1711826 [SCOPUS ]. Google Citation
Sonia Kumari Shishodia, Jata Shankar (2020). Exploration of Mycelial Proteins from Aspergillus terreus Revealed Ribosome Biogenesis and Antioxidant Enzymes. Current Proteomics, 17 (5), pp. 433-455, DOI: https://doi.org/10.2174/1570164617666191004163734 [SCOPUS , SCI ]. Google Citation
Sonia K. Shishodia, Shraddha Tiwari, Jata Shankar (2019). Resistance mechanism and proteins in Aspergillus species against antifungal agents. Mycology: An International Journal on Fungal Biology, 10 (2019), pp. 151-165, DOI: https://doi.org/10.1080/21501203.2019.1574927 [SCOPUS ]. Google Citation
Shraddha Tiwari, Sonia K. Shishodia, Jata Shankar (2019). Docking analysis of hexanoic acid and quercetin with seven domains of polyketide synthase A provided insight into quercetin-mediated aflatoxin biosynthesis inhibition in Aspergillus flavus. 3 Biotech, 2019 (9), pp. 1-11, DOI: https://doi.org/10.1007/s13205-019-1675-y [SCOPUS , SCI ]. Google Citation
Raman Thakur, Jata Shankar (2019). Proteome Analysis Revealed Jak/Stat Signaling and Cytoskeleton Rearrangement Proteins in Human Lung Epithelial Cells During Interaction with Aspergillus terreus. Current Signal Transduction Therapy, 14 (1), pp. 55-67, DOI: 10.2174/1574362413666180529123513 [SCOPUS ]. Google Citation
Jata Shankar, Gustavo C Cerqueira, Jennifer R Wortman, Karl V Clemons, David A Stevens (2018). RNA-Seq Profile Reveals Th-1 and Th-17-Type of Immune Responses in Mice Infected Systemically with Aspergillus fumigatus. Mycopathologia, 183 (2018), pp. 645-658, DOI: https://doi.org/10.1007/s11046-018-0254-9 [SCOPUS , SCI ]. Google Citation
Jata Shankar, Shraddha Tiwari, Sonia Shishodia, Manali Gangwar, Shanu Hoda, Raman Thakur, Pooja Vijayaraghavan (2018). Molecular insights into development and virulence determinants of Aspergilli: A proteomic perspective. Frontiers in Cellular and Infection Microbiology, 8 (2018), pp. 1-12, DOI: https://doi.org/10.3389/fcimb.2018.00180 [SCOPUS , SCI , UGC Care ]. Google Citation
Shraddha Tiwari, Jata Shankar (2018). Integrated proteome and HPLC analysis revealed quercetin-mediated inhibition of aflatoxin B1 biosynthesis in Aspergillus flavus. 3 Biotech, 2018 (8), pp. 47-, DOI: 10.1007/s13205-017-1067-0. [SCOPUS , SCI ]. Google Citation
Raman Thakur, Jata Shankar (2017). Comprehensive in-silico Analysis of High-risk Non-synonymous SNPs in Dectin-1 Gene of Human and their Impact on Protein Structure. Current Pharmacogenomics and Personalized Medicine, 15 (2), pp. 144-155, DOI: 10.2174/1875692116666180115142706 [SCOPUS ]. Google Citation
Shraddha Tiwari, Nupur Gupta, Udayabanu M, Jata Shankar (2017). Anti-aspergillus properties of phytochemicals against aflatoxin producing Aspergillus flavus and Aspergillus parasiticus. National Academy Science Letters, 40 (2017), pp. 267-271, DOI: 10.1007/s40009-017-0569-y [SCOPUS , SCI ]. Google Citation
Raman Thakur, Jata Shankar (2017). Proteome Profile of Aspergillus terreus Conidia at Germinating Stage: Identification of Probable Virulent Factors and Enzymes from Mycotoxin Pathways. Mycopathologia, 182 (2017), pp. 771-784, DOI: 10.1007/s11046-017-0161-5 [SCOPUS , SCI ]. Google Citation
Raman Thakur, Jata Shankar (2017). New Treatment Regime for Aspergillus Mediated Infections. Virology & Mycology, 6 (1), pp. 1000163-1-1000163-2, DOI: 10.4172/2161-0517.1000163 []. Google Citation
Raman Thakur, Jata Shankar (2016). In silico Identification of Potential Peptides or Allergen Shot Candidates Against Aspergillus fumigatus . BioResearch Open Access, 5 (1), pp. 330-341, DOI: 10.1089/biores.2016.0035 [SCOPUS ]. Google Citation
Shraddha Tiwari, Raman Thakur, Gunjan Goel, Jata Shankar (2016). Nano-LC-Q-TOF Analysis of Proteome Revealed Germination of Aspergillus flavus Conidia is Accompanied by MAPK Signalling and Cell Wall Modulation. Mycopathologia, 181 (2016), pp. 769-786, DOI: 10.1007/s11046-016-0056-x [SCOPUS , SCI ]. Google Citation
Raman Thakur, Jata Shankar (2016). In silico Analysis Revealed High-risk Single Nucleotide Polymorphisms in Human Pentraxin-3 Gene and their Impact on Innate Immune Response against Microbial Pathogens. Frontiers in microbiology, 7 (Article No.192), pp. 1-12, DOI: 10.3389/fmicb.2016.00192 [SCOPUS , SCI ]. Google Citation
Raman Thakur, Shraddha Tiwari, Jata Shankar (2016). Differential Expression Pattern of Heat Shock Protein Genes in Toxigenic and Atoxigenic Isolate of Aspergillus flavus. British Microbiology Research Journal, 14 (2), pp. 1-9, DOI: 10.9734/BMRJ/2016/25368 []. Google Citation
Shraddha Tiwari, Raman Thakur, Jata Shankar (2015). Role of Heat-Shock Proteins in Cellular Function and in the Biology of Fungi. Biotechnology Research International, 2015 (Article ID 132635), pp. 1-12, DOI: http://dx.doi.org/10.1155/2015/132635 []. Google Citation
Raman Thakur, Rajesh Anand, Shraddha Tiwari, Agam P. Singh, Bhupendra N. Tiwary, Jata Shankar (2015). Cytokines induce effector T-helper cells during invasive aspergillosis; what we have learned about T-helper cells?. Frontiers in microbiology, 6 (Article No. 429), pp. 1-6, DOI: 10.3389/fmicb.2015.00429 [SCOPUS , SCI ]. Google Citation
R. Anand, Jata Shankar, B.N. Tiwary, A.P. Singh (2015). Aspergillus flavus induces granulomatous cerebral aspergillosis in mice with display of distinct cytokine profile. Cytokine, 72 (2), pp. 166-172, DOI: doi:10.1016/j.cyto.2015.01.006 [SCOPUS , SCI , UGC Care ]. Google Citation
Tarun Kumar Patel, Rajesh Anand, Agam Prasad Singh, Jata Shankar, Bhupendra N. Tiwary (2015). Evaluation of aflatoxin B1 biosynthesis in A. flavus isolates from central india and identification of atoxigenic isolates. Biotechnology and Bioprocess Engineering, 19 (6), pp. 1105-1113, DOI: 10.1007/s12257-014-0464-z [SCOPUS , SCI ]. Google Citation

Conference(s) :

Jata Shankar, Raman Thakur, Shanu Hoda, Shraddha Tiwari, Pooja Vijayaraghavan (2017). Proteome profile provided molecular insight into germination of Aspergilli and biosynthesis of secondary metabolites. Proceedings of the International Congress on Analytical Proteomics (V ICAP 2017) [5th : Caparica, Portugal. : 3-6 July, 2017 ], pp.-.. Google Citation
Shraddha Tiwari, Raman Thakur, Gunjan Goel, Jata Shankar (2016). Identification and Functional categorization of Protein Involved in Germination of Aspergillus Flavus Conidia. Proceedings of the Advances Against Aspergillosis [7th : Manchester University, Manchester UK : 3-5 March, 2016], pp.-.. Google Citation

Biotechnology and Bioinformatics

FACULTY NAMES