Biotechnology and Bioinformatics

Dr. Harish Changotra
Associate Professor
( 91)01792-239343
harish.changotra@juit.ac.in
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Biography :

Professional Experience

(07/ 2015 – Present), Associate Professor, Department of Biotechnology, Jaypee University of Information Technology, Waknaghat, Solan 173 234, Himachal Pradesh, India

(07/ 2011 – 06/ 2015), Assistant Professor, Department of Biotechnology, Jaypee University of Information Technology, Waknaghat, Solan 173 234, Himachal Pradesh, India

(02/ 2006 - 12/2010), Postdoctoral Scientist, Department of Microbiology and Immunology, Louisiana State University Health Sciences Center, Shreveport, Louisiana, US.

(07/ 2005 - 02/ 2006), Postdoctoral Fellow, Molecular Genetics Division, JL Pettis Memorial VA Medical Center, Loma Linda, California, US.

(09/ 2004 - 07/ 2005), Postdoctoral Fellow, National Institute of Immunology, New Delhi, India.

Author Publication Profile:

Publication(s):
2020 (4)	2019 (1)	2018 (8)	2017 (12)	2016 (8)	2015 (2)
2014 (2)	2013 (1)	All

Journal(s) :

Sharma A, Kaur S, Sarkar M, Sarin BC, Harish Changotra (2020). The AGE-RAGE axis and RAGE genetics in Chronic Obstructive Pulmonary Disease.. Clinical Reviews in Allergy & Immunology, (), -. Google Citation
Sharma A, Kaur S, Duseja A, Harish Changotra (2020). The autophagy gene ATG16L1 (T300A) variant is associated with the risk and progression of HBV infection. Infection, Genetics and Evolution, 84 (), 104404-
Kaur S, Harish Changotra (2020). The Beclin 1 interactome: modification and roles in the pathology of autophagy-related disorders.. Biochemie, 175 (), 34-49. Google Citation
Singh S, Yennamalli, Harish Changotra (2020). Identification of nsSNPs of transcription factor E2F1 predisposing individuals to Lung Cancer and Head and Neck Cancer.. Mutation Research: Fundamental and Molecular Mechanisms of Mutagenesis, 621 (), 111704-. Google Citation
Singh S, Kaur S, Gupta M, Seam RK, Khosla R, Harish Changotra (2019). E2F1 gene variant rs2071054 is a risk factor for head and neck and cervical cancers.. Gene Reports, 17 (), 100476-
Sanjay Singh, Manish Gupta, Rajeev Kumar Seam, Harish Changotra (2018). E2F1 Genetic Variants and Risk of Cervical Cancer in Indian Women. International Journal of Biological Markers, 33 (4), 389-394. Google Citation
Sanjay Singh, Manish Gupta, Ambika Sharma, Rajeev Kumar Seam, Harish Changotra (2018). The Nonsynonymous Polymorphisms Val276Met and Gly393Ser of E2F1 Gene are Strongly Associated with Lung, and Head and Neck Cancers. Genetic Testing and Molecular Biomarkers, 22 (8), 1-5. Google Citation
Yawalkar R, Harish Changotra, Gupta GL (2018). Protective influences of N-acetylcysteine against alcohol abstinence-induced depression by regulating biochemical and GRIN2A, GRIN2B gene expression of NMDA receptor signaling pathway in rats. Neurochemistry International , 118 (2018), 73-81. Google Citation
Sharma A, Harish Changotra (2018). Mutagenic Primer Based PCR-RFLP Assay for Genotyping IRGM Gene Promoter Variant rs4958843 (C/T). Journal of Clinical Laboratory Analysis , 32 (4), e22346 -
NutanThakur, Harish Changotra, Neelam Grover, Jitendraa Vashistt (2018). Elucidation of Bacterial Species during Childhood Diarrhea through 16S rRNA Illumina Miseq approach. Meta Gene, 16 (June 2018), 234-240
Nutan Thakur, Swapnil Jain, Harish Changotra, Rahul Shrivastava, Yashwant Kumar, Neelam Grover, Jitendraa Vashistt (2018). Molecular characterization of diarrheagenic Escherichia coli pathotypes: Association of virulent genes, serogroups, and antibiotic resistance among moderate-to-severe diarrhea patients. Journal of Clinical Laboratory Analysis , In press (), -
Thakur N, Harish Changotra, Rahul Shrivastava, Grover N, Jitendraa Vashistt (2018). Estimation of Vibrio species incidences and antibiotic resistance in diarrhea patients. Asian Journal of Pharmaceutical and Clinical Research, 11 (1), 369-373. Google Citation
Harish Changotra, Vij A (2017). Rotavirus-Virus Like Particles (RV-VLPs) Vaccines: An Update. Reviews in Medical Virology, Online (), -. Google Citation
Sharma A, Harish Changotra (2017). Novel Artificial Restriction Fragment Length Polymorphism Methods for Genotyping Immunity-related GTPase M Promoter Polymorphisms. Inflammatory Bowel Disease , 23 (10), e52-e53
Avni Vij, Raghu M. Yennamalli , Harish Changotra (2017). Non-Synonymous Single Nucleotide Polymorphisms of ATG5 Destabilize ATG12 - ATG5 / ATG16L1 Complex: an enzyme with E3 like activity of ubiquitin conjugation system. Meta Gene, 13 (2017), 38-47
Randhawa R, Duseja A, Changotra H (2017). A novel Tetra-primer ARMS-PCR based assay for genotyping SNP rs12303764(G/T) of human Unc-51 Like Kinase 1 gene. Molecular Biology Reports, 44 (1), 1-4
Agarwal S, Harish Changotra (2017). Association of protein tyrosine phosphatase, non-receptor type 22 +1858C→T polymorphism and susceptibility to vitiligo: Systematic review and meta-analysis. Indian Journal of Dermatology, Venereology and Leprology , 83 (2), 183-189
Jain S, Thakur N, Jitendraa Vashistt, Grover N, Krishnan T, Harish Changotra (2016). Predominance of Unusual Rotavirus G1P[6] Strain in North India: an evidence from hospitalized children and adult diarrheal patients. Infection, Genetics and Evolution, 46 (), 65-70
Jain S, Jitendraa Vashistt, Gupta K, Kumar A, Harish Changotra (2016). Molecular Analysis of VP7 Gene of Rotavirus G1 Strains Isolated from North India. Current Microbiology, 73 (6), 781-789. Google Citation
Nutan, Swapnil Jain, Shilpa, Akanksha Tomar, Harish Changotra, Jitendraa Vashistt (2016). Computational Tools; Indispensable Armamentarium of Medical Biotechnology. Indian Journal of Science and Technology, 9 (32), 1-5
Vij A, Randhawa R, Parkash J, Harish Changotra (2016). Investigating Regulatory Signatures of Human Autophagy Related Gene 5 (ATG5) through Functional in Silico Analysis. Meta Gene, 9 (2016), 237-248
S.S. Patel, V. Mehta, Harish Changotra, Udayabanu M (2016). Depression mediates impaired glucose tolerance and cognitive dysfunction: a neuromodulatory role of rosiglitazone. Hormones and Behaviour, 78 (), 200-210
Harish Changotra, S. M. Turk, A. Artigues, N. Thakur, M. Gore, L. Hutt-Fletcher (2016). Epstein-Barr Virus Glycoprotein gM can Interact with the Cellular Protein p32 and Knockdown of p32 Impairs Virus Assembly. Virology, 489 (February, 2016), 223-232. Google Citation
S. Jain, Nutan Thakur, N. Grover, Jitendraa Vashistt, Harish Changotra (2016). Prevalence of Rotavirus in Diarrheal Diseases in Himachal Pradesh, India. VirusDisease , 27 (1), 77-83. Google Citation
S. Agarwal, G. Kaur, R. Randhawa, V. Mahajan, R. Bansal, Harish Changotra (2016). Liver X Receptor-α polymorphisms (rs11039155 and rs2279238) are associated with susceptibility to vitiligo. Meta Gene, 8 (June 2016), 33-36
Harish Changotra (2015). The Emerging Roles of Human Immunity-Related GTPase M (IRGM) Gene. International Journal for Computational Biology, 4 (1), 55-61
Rohit Randhawa, Manika Sehgal, Tiratha Raj Singh, Ajay Duseja, Harish Changotra (2015). Unc-51 like kinase 1 (ULK1) in silico analysis for biomarker identification: A vital component of autophagy. Gene , 62 (1), 40-49
Swapnil Jain, Jitendraa Vashistt, Harish Changotra (2014). Rotaviruses: Is their surveillance needed?. Vaccine, 32 (27), 3367-3378. Google Citation
Harish Changotra, Sehajpal P.K. (2013). An improved method for the isolation of hepatitis B virus DNA from human serum. Indian Journal of Virology, 24 (2), 174-179. Google Citation

Conference(s) :

Sihra AK, Handa V, Singh S, Seam RK, Gupta M, Harish Changotra (2018). Intronic variant of E2F1 gene associated with lung cancer risk in Himachal Pradesh population. Proceedings of the Annual Meeting of Indian Society of Human Genetics on Population and Medical Genomics [43rd : CSIR-CCMB, Hyderabad, India : 12-14 March 2018], pp.-.. Google Citation
Thakur N, Harish Changotra, Jitendraa Vashistt (2017). Next Generation Sequencing: An amalgam of disease biology and computer algorithms for comprehensive exploration of Infectious agents. Proceedings of the IEEE INDIACom-2017 [ : 1-3 March, 2017], pp.4044-40448.. Google Citation
Singh S, Seam RK, Gupta MK, Harish Changotra (2017). Association of G393S Variant of E2F1 gene with Lung and HNC cancer risk in North Indian Population. Proceedings of the Punjab Science Congress [20th : IET Bhaddal, Ropar, Punjab : 7-9 February 2017], pp.-.. Google Citation
Sharma A, Harish Changotra (2017). Mutagenic primer based PCR-RFLP assays for genotyping of three promoter region SNPs (rs4958842, rs4958843 and rs4958846) of IRGM gene. Proceedings of the [20th Punjab Science Congress : 7-9 February 2017], pp.-.. Google Citation
Sharma A, Duseja A, Harish Changotra (2017). Association of IRGM gene variant rs4958842 with Hepatitis B infection in North Indian population. Proceedings of the 20th Punjab Science Congress [IET Bhaddal, Ropar, Punjab : 7-9 February 2017], pp.-.. Google Citation
Sharma A, Duseja A, Harish Changotra (2017). Association of IRGM promoter polymorphisms with hepatitis B virus infection in North Indian population. Proceedings of the Annual Meeting of the Indian Society of Human Genetics & International Symposium on Trends in Human Genetic Research & Management [42nd : Indian Institute of Sciences, Bangalore : 2-4 March, 2017], pp.-.. Google Citation
Vij A, Harish Changotra (2017). Role of Autophagy related gene 5 (ATG5) single nucleotide polymorphism rs2245214 (C/G) with HBV susceptibility in North Indian population. Proceedings of the International Conference on Recent Research in Biomedical Engineering, Cancer Biology, Stem Cells, Bioinformatics and Applied Biotechnology (BECBAB-2017) [Jawaharlal Nehru University, New Delhi : 25 February, 2017], pp.-.. Google Citation
Singh S, Seam RK, Gupta MK, Raghu M. Yennamalli , Harish Changotra (2017). Prediction of Genetic marker in E2F1 Gene by a Computational Approach. Proceedings of the Annual Meeting of the Indian Society of Human Genetics & International Symposium on Trends in Human Genetic Research & Management [42nd : Indian Institute of Sciences, Bangalore : March, 2017], pp.-.. Google Citation
Randhawa R, Harish Changotra (2014). A Novel Multiplex T-ARMS-PCR Assay to Genotype IL28B Single Nucleotide Polymorphisms rs12979860 and rs8099917 Simultaneously. Proceedings of the New insights into Pharmacogenomics, Drug Development and Personalized Medicine [Bhagwan Mahavir Medical Research Institute, Hyderabad, India : July 18-19, 2014], pp.-.. Google Citation

Abstract/ Poster Presentations/ Invited Lectures in Conferences :

Harish Changotra (2019). Identification of deleterious non-synonymous single nucleotide polymorphisms in human becn1 gene by in silico analysis.. Proceedings of the International Conference on Recent Trends in Biotechnology and Bioinformatics (ICBAB-2019) [Jaypee University of Information Technology, Solan : 01-03 August 2019], pp.-.. Google Citation
Singh S, Seam RK, Gupta M, Harish Changotra (2018). Association of rs3213173 (C/T) polymorphism of E2F1 gene with lung cancer risk in Himachal Pradesh population. Proceedings of the International Conference on Futuristic Trends in Network and Communication Technologies (FTNCT-2018) [1st. : Jaypee University of Information Technology : 9-10 February 2018], pp.-.. Google Citation
Handa V, Sihra AK, Singh S, Seam RK, Gupta M, Harish Changotra (2018). Intronic variant (rs3213150) of E2F1 gene is not associated with cervical cancer risk in Himachal Pradesh Population. Proceedings of the Annual Meeting of Indian Society of Human Genetics on Population and Medical Genomics [43rd : CSIR-CCMB, Hyderabad, India : 12-14 March 2018], pp.-.. Google Citation
Sharma A, Duseja A, Harish Changotra (2018). Association of IRGM Gene Promoter Polymorphisms with HBV Infection. Proceedings of the Annual Meeting of Indian Society of Human Genetics on Population and Medical Genomics [43rd : CSIR-CCMB, Hyderabad, India : 12-14 March 2018], pp.-.. Google Citation
Sharma S, Sharma A, Sharma A, Singh S, Mahajan V, Bansal R, Harish Changotra (2017). Non-synonymous variant His568Tyr (rs6336) of Tyrosinase gene is associated with vitiligo protection in Himachal Pradesh population. Proceedings of the Himachal Pradesh Science Congress [2nd. : Shimla, Himachal Pradesh : 20-21 November 2017], pp.-.. Google Citation
Harish Changotra (2016). Host genetics and hepatitis B virus infection. Proceedings of the International Symposium on Genomic Medicine: personalized care for me and you [Doaba College, Jalandhar, Punjab, India : October 18 , 2016], pp.-.. Google Citation
Nutan, Swapanil Jain, Harish Changotra, Rahul Shrivastava, Jitendraa Vashistt (2015). Metagenomic Studies in Relation to Diarrheal Diseases. Proceedings of the International Congress on Friedreichs Ataxia and DNA Structure in Health & Disease [All India Institute of Medical Sciences, New Delhi, India. : 11-13 April , 2015], pp.-.. Google Citation
T. Dogra, S. Mukherjee, V. Joshi, R. Khosla, Harish Changotra (2015). Role of genetic variants in Autophagy related gene 7 (Atg7) (rs35807939) in Asthma in North Indian population. Proceedings of the National Conference on Recent Trends in Biomedical Engineering, Cancer Biology, Bioinformatics and Applied Biotechnology [Jawaharlal Nehru University, New Delhi : 28 November, 2015], pp.-.. Google Citation
A. Vij, Harish Changotra (2015). In silico prediction and analysis of non synonymous single nucleotide polymorphisms (nsSNPs) in autophagy related gene 5 (ATG5). Proceedings of the National Conference on Recent Trends in Biomedical Engineering, Cancer Biology, Bioinformatics and Applied Biotechnology [Jawaharlal Nehru University, New Delhi : 28 November, 2015], pp.-.. Google Citation
A. Sharma, A. Duseja, Harish Changotra (2015). Association of autophagy gene Atg16L1 variant rs2241879 and Chronic Hepatitis B in North Indian population. Proceedings of the National Conference on Recent Trends in Biomedical Engineering, Cancer Biology, Bioinformatics and Applied Biotechnology [Jawaharlal Nehru University, New Delhi : 28 November], pp.-.. Google Citation
Jha D, Joshi V, Sharma A, Harish Changotra (2015). Autophagy Related Gene 5 (Rs17587319) Variants in Asthmatic Patients in North Indian Population. Proceedings of the 6th World Congress on Biotechnology [New Delhi, India : 05-07 October, 2015], pp.-.. Google Citation
S. Jain, Jitendraa Vashistt, Harish Changotra (2015). Predominance of Rotavirus G1P[6] strain in Himachal Pradesh, India.. Proceedings of the Asian Vaccine Conference [5th : Hanoi, Vietnam : 12-14 June 2015], pp.-.. Google Citation
Radhika Batta, Poonam, Harish Changotra, Rahul Shrivastava, Jitendraa Vashistt (2015). Assessment of the resistance pattern in Klebsiella spp. against β-lactams in Himachal Pradesh. Proceedings of the National Conference on Emerging Trends in Host-Microbe Interactions [DAV University, Jalandhar (Punjab) : 17 -18 April, 2015], pp.-.. Google Citation
Jain S, Tiratha Raj Singh, Jitendraa Vashistt, Harish Changotra (2015). Molecular analysis of G1 rotavirus strains isolated from Himachal Pradesh. Proceedings of the National Conference on Emerging Trends in Host-Microb Interactions [Jalandhar, Punjab : 17-18 April 2015], pp.-.. Google Citation
R. Randhawa, M. Sehgal, Tiratha Raj Singh, A. Duseja, Harish Changotra (2014). Computational analysis of unc-51 like kinase 1 (ULK1) gene and its association with autophagy. Proceedings of the International Conference on “Stem Cell Research, Cancer Biology, Biomedical Sciences, Bioinformatics and Applied Biotechnology [New Delhi, India : 1 -2 November 2014], pp.106-.. Google Citation
R. Randhawa, Harish Changotra (2014). Interleukin-28B SNPs rs12979860 and rs8099917 allele frequencies from North India using a novel in-house multiplex T-ARMS-PCR. Proceedings of the International Conference on “Stem Cell Research, Cancer Biology, Biomedical Sciences, Bioinformatics and Applied Biotechnology [New Delhi, India : 1-2 November 2014], pp.107-.. Google Citation
Nutan, S. Jain, N. Grover, Y. Kumar, Harish Changotra, Jitendraa Vashistt (2014). Identification, characterization of prevalent diarrheagenic bacterial pathogens from regions of Himachal Pradesh. Proceedings of the International Conference on Life science Biotechnology & Bioinformatics [Noida, India : 29-30 August 2014], pp.169-.. Google Citation
S. Jain, N. Kumar, Nutan, Jitendraa Vashistt, Harish Changotra (2014). Phylogenetic analysis to study the evolution of Rotavirus G1P [6] strain isolated from Himachal Pradesh. Proceedings of the International Conference on “Stem Cell Research, Cancer Biology, Biomedical Sciences, Bioinformatics and Applied Biotechnology [New Delhi, India : 1 -2 November 2014], pp.108-.. Google Citation

Biotechnology and Bioinformatics

FACULTY NAMES