FAQ (Frequently Asked Questions)
1. What is TCGDB?
2. Why TCGDB was created?
1) Catalog gene-related facts of the thyroid diseases cumulated in the literature database in structured format for fast and easy access;
2) To deliver value added information;
3) To serve researchers and clinicians a system to browse through and extract the basic and advanced information about the genes involved in thyroid cancer.
3. What is unique about TCGDB?
b) Using TCGDB a user can extract information regarding the aberrant biological process a gene is involved that leads to thyroid carcinogenesis.
c) A user can find if his gene of ineterest is differentially expressed in thyroid cancer.
d) Hypermethylation of tumor suppressor genes have long been associated with various cancers including cervical cancer. It is now considered one of the important mechanism for silencing gene expression and in neoplasia abnormal patterns of DNA methylation is observed. TCGDB facilitates and is helpful in providing information about tumor suppressor genes that have been found hypermethylated in thyroid cancer.
e) Also TCGDB facilitates identification of orthologous genes in various eukaryotic genomes corresponding to the user searched gene.
4. Does this database represent all genes associated with Thyroid Cancer and disorders?
5. To whom can I report a bug or discrepancy?
Ans 1. TCGDB (Thyroid Cancer and Disorder Gene Database) is a comprehensive collection of the genes contributing to the etiology and pathogenesis of thyroid cancer and disorders.
2. Why TCGDB was created?
Ans 2. Carcinoma of the thyroid is the most common endocrine disorders which affects approx. 4.2 crore Indians. Inspite of the large population affected from this cancer still at present there is no database that catalogues genes involved in thyroid cancer. Therefore, TCGDB was constructed to:
1) Catalog gene-related facts of the thyroid diseases cumulated in the literature database in structured format for fast and easy access;
2) To deliver value added information;
3) To serve researchers and clinicians a system to browse through and extract the basic and advanced information about the genes involved in thyroid cancer.
3. What is unique about TCGDB?
Ans 3. a) TCGDB, to the best of our knowledge is the first collection of genes associated with TC, which has been manually curated.
b) Using TCGDB a user can extract information regarding the aberrant biological process a gene is involved that leads to thyroid carcinogenesis.
c) A user can find if his gene of ineterest is differentially expressed in thyroid cancer.
d) Hypermethylation of tumor suppressor genes have long been associated with various cancers including cervical cancer. It is now considered one of the important mechanism for silencing gene expression and in neoplasia abnormal patterns of DNA methylation is observed. TCGDB facilitates and is helpful in providing information about tumor suppressor genes that have been found hypermethylated in thyroid cancer.
e) Also TCGDB facilitates identification of orthologous genes in various eukaryotic genomes corresponding to the user searched gene.
4. Does this database represent all genes associated with Thyroid Cancer and disorders?
Ans 4. No. This collection is the result of first round curation and we will update database with new data.
5. To whom can I report a bug or discrepancy?
Ans 5. Please refer to the "Contact" page.