Escherichia coli paa ABA70464 21795517;19403767 Enterohemorrhagic E.coli It is involved in the initial bacterial adherence required for the Attaching and effacing (A/E) activity. PF13531.1 0 adhesin C3NT57_VIBCJ Accessory colonization factor AcfC OS=Vibrio cholerae serotype O1 (strain MJ-1236)\nC3LT92_VIBCM Accessory colonization factor AcfC OS=Vibrio cholerae serotype O1 (strain M66-2)\nA5F387_VIBC3 Accessory colonization factor AcfC OS=Vibrio cholerae serotype O1 (strain ATCC 39541 / Ogawa 395 /O395)\nE6RUF5_CAMJS Major antigenic peptide PEB3 OS=Campylobacter jejuni subsp. jejuni (strain S3) 0 1 Escherichia coli ehxA YP_308794 20223897;14766831 Enterohemorrhagic E.coli It has ability to induce the formation of a characteristic histological feature known as an attaching-and-effacing (A/E) lesion on target epithelial cells. PF00353.14;PF08339.5;PF02382.10 0 adhesin A1JSQ0_YERE8 Metalloprotease OS=Yersinia enterocolitica serotype O:8 / biotype 1B (strain 8081)\nA0KNW4_AERHH Flagellin hook IN motif family OS=Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 /NCIB 9240)\nA0KLQ4_AERHH Structural toxin protein RtxA OS=Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / NCIB 9240) 0 1 Escherichia coli subAB YP_308821 20223897;19940059 Enteropathogenic E.coli (i) SubAB-induces ER stress (ii) induces apoptosis in HeLa cells PF02918.10 0 toxin A1JKZ3_YERE8 Putative exported protein OS=Yersinia enterocolitica serotype O:8 / biotype 1B (strain 8081) 3DWA 1 1 Escherichia coli lpfA YP_002331264 21795517;20223897;19403767;17021100;21473096 Enterohemorrhagic E.coli It acts as cell adhesion molecule to induce pathogenesis. PF09816.4;PF00419.15 0 toxin E1WD69_SALTS Long polar fimbria protein A (LpfA) OS=Salmonella typhimurium (strain SL1344)\nB5R4M7_SALEP Long polar fimbria protein A (LpfA) OS=Salmonella enteritidis PT4 (strain P125109)\nF5ZXJ3_SALTU Long polar fimbrial protein A OS=Salmonella typhimurium (strain ATCC 68169 / UK-1) 0 1 Escherichia coli espP NP_052685 22370037;20223897;21239543 Enterohemorrhagic E.coli It is a serine protease capable of cleaving pepsin A and human coagulation factor V which may contribute to the mucosal hemorrhage observed in hemorrhagic colitis. PF13018.1;PF02395.11;PF03797.14 0 autotranspoter Q83JR2_SHIFL Serine protease OS=Shigella flexneri\nQ31TN1_SHIBS Serine protease OS=Shigella boydii serotype 4 (strain Sb227)\nSEPA_SHIFL Serine protease sepA autotransporter OS=Shigella flexneri 3SZE  1 1 Escherichia coli espI O69740 17979986;20223897;15496394 Enterohemorrhagic E.coli Co-localises with the Golgi mannosidase II when translocated by bacteria funcion unknown. PF13614.1;PF09572.5 0 toxin A1W1A4_CAMJJ Conserved domain protein OS=Campylobacter jejuni subsp. jejuni serotype O:23/36 (strain 81-176)\nE6RUP8_CAMJS Putative uncharacterized protein OS=Campylobacter jejuni subsp. jejuni (strain S3)\nQ87HL9_VIBPA Putative cation efflux system (AcrB/AcrD/AcrF family) OS=Vibrio parahaemolyticus 0 1 Escherichia coli epeA AAL18821 20223897 Enterohemorrhagic E.coli It acts as an autotransporter protease. PF13018.1;PF02395.11;PF03797.14 0 autotranspoter SEPA_SHIFL Serine protease sepA autotransporter OS=Shigella flexneri\nPIC_SHIFL Serine protease pic autotransporter OS=Shigella flexneri\nQ83JR2_SHIFL Serine protease OS=Shigella flexneri 1WXR 1 1 Escherichia coli CS31A ACD54421 19067217;11856586;12710494 Enterotoxigenic E.coli CS31A is a K88-related non-fimbrial adhesin which diffusely adhered to Caco-2 and/or HEp-2 cells and produced a major surface protein of either 30 or 30.5 kDa according to the strain. PF02432.10 0 adhesin A1JMA6_YERE8 Putative RTX-family toxin transporter OS=Yersinia enterocolitica serotype O:8 / biotype 1B (strain 8081) 0 1 Escherichia coli CNF1 Q1R2U0 15583337;21658736;15058198;15191387;12350513;19714857 Enterohemorrhagic E.coli CNF1 permanently activates the small GTP-binding proteins of the Rho family that beside controlling the actin cytoskeleton organization also play a pivotal role in a large number of other cellular processes including cell cycle regulation. PF05785 0 toxin A1JN83_YERE8 Putative uncharacterized protein OS=Yersinia enterocolitica serotype O:8 / biotype 1B (strain 8081)\nQ87GJ5_VIBPA Cytotoxic necrotizing factor OS=Vibrio parahaemolyticus\nQ5CTE3_CRYPI Putative uncharacterized protein OS=Cryptosporidium parvum (strain Iowa II) 1HQ0  1 1 Escherichia coli pap1 AEK21629 15191387;15583337;12350513 Enterohemorrhagic E.coli It plays a central role in determining pap gene expression in both phase-ON and phase-OFF cells. PF13155.1;PF13481.1 0 toxin Q0T1N5_SHIF8 Putative bacteriophage protein OS=Shigella flexneri serotype 5b (strain 8401)\nQ83LW1_SHIFL Putative bacteriophage protein OS=Shigella flexneri\nE6RVB0_CAMJS DNA primase OS=Campylobacter jejuni subsp. jejuni (strain S3)\nA1JQX2_YERE8 DNA primase OS=Yersinia enterocolitica serotype O:8 / biotype 1B (strain 8081) 0 1 Escherichia coli hlyA AAA20544 15191387;15583337;12350513;22120799 Enterohemorrhagic E.coli It is cytotoxic to many types of cells: erythrocytes granulocytes monocytes endothelial cells and renal epithelial and stimulates the release of IL-1 and TNF. PF02382.10;PF00353.14;PF08339.5 0 toxin A0KNW4_AERHH Flagellin hook IN motif family OS=Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / NCIB 9240)\nA1JSQ0_YERE8 Metalloprotease OS=Yersinia enterocolitica serotype O:8 / biotype 1B (strain 8081)\nQ87NB6_VIBPA Putative uncharacterized protein VP1952 OS=Vibrio parahaemolyticus 0 1 Escherichia coli aer NP_289646 15191387; 12350513 Enterohemorrhagic E.coli Signal transducer for aerotaxis. The aerotactic response is the accumulation of cells around air bubbles. The nature of the sensory stimulus detected by this protein is the proton motive force or cellular redox state. It uses a FAD prosthetic group as a redox sensor to monitor oxygen levels PF08447.6;PF13567.1;PF00672.20;PF06103.6;PF00015.16;PF02875.16 0 signal transducer "Q31WW2_SHIBS Aerotaxis sensor receptor, flavoprotein OS=Shigella boydii serotype 4 (strain Sb227)\nB5QZ52_SALEP Aerotaxis receptor protein OS=Salmonella enteritidis PT4 (strain P125109)\nE1WI03_SALTS Aerotaxis receptor protein OS=Salmonella typhimurium (strain SL1344)" 0 1 Escherichia coli sfa NP_286927 15191387; 12350513 Enterohemorrhagic E.coli It is a fimbrial adhesins which enables bacteria to attach to eucaryotic cells. PB004920 1 adhesin Q83RV9_SHIFL Suppressor of fabA and ts growth mutation OS=Shigella flexneri\nQ31YQ3_SHIBS Suppresses fabA and ts growth mutation OS=Shigella boydii serotype 4 (strain Sb227) 0 1 Escherichia coli afaI CAA48941 15191387;19067217 Enterohemorrhagic E.coli It belongs to the Dr-adhesin family and bind to the Dr blood group antigen and also agglutinate human erythrocytes in the presence of D-mannose (mannose-resistant hemagglutination (MRHA)). PF12393.3;PF04619.7;PF10042.4 0 adhesin E1W9W6_SALTS Glutamine-binding periplasmic protein OS=Salmonella typhimurium (strain SL1344)\nF5ZNP3_SALTU Glutamine ABC transporter periplasmic protein OS=Salmonella typhimurium (strain ATCC 68169 / UK-1)\nQ0T6F0_SHIF8 Periplasmic glutamine-binding protein OS=Shigella flexneri serotype 5b (strain 8401) 1UT2 1 1 Escherichia coli CNF2 YP_003034083 21658736;19714857 Enterohemorrhagic E.coli Cytotoxic necrotizing factor type 2 produced by virulent Escherichia coli modifies the small GTP-binding proteins Rho involved in assembly of actin stress fibers. PF05785.7 0 toxin A1JN83_YERE8 Putative uncharacterized protein OS=Yersinia enterocolitica serotype O:8 / biotype 1B (strain 8081)\nQ87GJ5_VIBPA Cytotoxic necrotizing factor OS=Vibrio parahaemolyticus\nQ5CTE3_CRYPI Putative uncharacterized protein OS=Cryptosporidium parvum 0 1 Escherichia coli CDT-I BAF63393 21658736;22252871;19714857 Enterohemorrhagic E.coli Cytolethal distending toxins (CDTs) are inhibitory cyclomodulins which block eukaryotic cell proliferation. PF04383.8;PF10549.4 0 toxin Q0T7R9_SHIF8 Putative bacteriophage protein OS=Shigella flexneri serotype 5b (strain 8401)\nE1WGR2_SALTS Predicted bacteriophage protein OS=Salmonella typhimurium (strain SL1344)\nF5ZRB3_SALTU Putative uncharacterized protein OS=Salmonella typhimurium (strain ATCC 68169 / UK-1) 0 1 Escherichia coli CDT-II Q46669 21658736;22252871;19714857 Enterohemorrhagic E.coli Cytolethal distending toxins (CDTs) are inhibitory cyclomodulins which block eukaryotic cell proliferation PF03372.18 0 toxin "E6RT81_CAMJS Cytolethal distending toxin subunit B OS=Campylobacter jejuni subsp. jejuni (strain S3)\nA1VXG3_CAMJJ Cytolethal distending toxin, subunit B OS=Campylobacter jejuni subsp. jejuni serotype O:23/36 (strain 81-176)\nA8FJN4_CAMJ8 Cytolethal distending toxin, type I deoxyribonuclease-like protein OS=Campylobacter jejuni subsp. jejuni serotype O:6 (strain 81116 / NCTC 11828)" 2F1N 1 1 Escherichia coli CDT-III YP_003034080 21658736;22252871;19714857 Enterohemorrhagic E.coli Cytolethal distending toxins (CDTs) are inhibitory cyclomodulins which block eukaryotic cell proliferation PF03372.18 0 toxin "E6RT81_CAMJS Cytolethal distending toxin subunit B OS=Campylobacter jejuni subsp. jejuni (strain S3)\nA1VXG3_CAMJJ Cytolethal distending toxin, subunit B OS=Campylobacter jejuni subsp. jejuni serotype O:23/36(strain 81-176)\nA8FJN4_CAMJ8 Cytolethal distending toxin, type I deoxyribonuclease-like protein OS=Campylobacter jejuni subsp. jejuni serotype O:6 (strain 81116 / NCTC 11828)" 0 1 Escherichia coli CDT-IV AAT92048 21658736;22252871;19714857 Enterohemorrhagic E.coli Cytolethal distending toxins (CDTs) are inhibitory cyclomodulins which block eukaryotic cell proliferation PF03372.18 0 toxin "A8FJN4_CAMJ8 Cytolethal distending toxin, type I deoxyribonuclease-like protein OS=Campylobacter jejuni subsp. jejuni serotype O:6 (strain 81116 / NCTC 11828)\nA1VXG3_CAMJJ Cytolethal distending toxin, subunit B OS=Campylobacter jejuni subsp. jejuni serotype O:23/36(strain 81-176" 0 1 Escherichia coli CDT-V P0A6Y1 21658736;22252871;19714857 Enterohemorrhagic E.coli Cytolethal distending toxins (CDTs) are inhibitory cyclomodulins which block eukaryotic cell proliferation PF00216.16;PF02649.9 0 toxin IHFB_SHIFL Integration host factor subunit beta OS=Shigella flexneri\nIHFB_SHIF8 Integration host factor subunit beta OS=Shigella flexneri serotype 5b (strain 8401)\nE1W713_SALTS Integration host factor subunit beta OS=Salmonella typhimurium (strain SL1344) 1IHF  1 1 Escherichia coli F17a AAD17512 21658736;22002588;19508558;10384887;19580980 Enterotoxigenic E.coli Essential fimbrial adhesion factor that mediates binding to N-acetylglucosamine-containing receptors in the host intestinal microvilli leading to colonization of the intestinal tissue and diarrhea or septicemia. Also confers adhesiveness to laminin and basement membranes PF00419.15 0 adhesin E1W8K1_SALTS Probable fimbrial protein OS=Salmonella typhimurium (strain SL1344)\nB5R4U1_SALEP Probable fimbrial protein OS=Salmonella enteritidis PT4 (strain P125109)\nF5ZMC1_SALTU Putative fimbrial major subunit OS=Salmonella typhimurium (strain ATCC 68169 / UK-1) 0 1 Escherichia coli F17b AAA23737 21658736;10384887;19580980 Enterotoxigenic E.coli Essential fimbrial adhesion factor that mediates binding to N-acetylglucosamine-containing receptors in the host intestinal microvilli leading to colonization of the intestinal tissue and diarrhea or septicemia. Also confers adhesiveness to laminin and basement membranes PF00419.15;PF13860.1;PF11909.3 0 adhesin A1JI62_YERE8 Putative fimbrial protein OS=Yersinia enterocolitica serotype O:8 / biotype 1B (strain 8081)\nE1W8K1_SALTS Probable fimbrial protein OS=Salmonella typhimurium (strain SL1344)\nB5R4U1_SALEP Probable fimbrial protein OS=Salmonella enteritidis PT4 (strain P125109) 0 1 Escherichia coli F17c Q47033 21658736;10384887;12710494;19580980 Enterotoxigenic E.coli Essential fimbrial adhesion factor that mediates binding to N-acetylglucosamine-containing receptors in the host intestinal microvilli leading to colonization of the intestinal tissue and diarrhea or septicemia. Also confers adhesiveness to laminin and basement membranes PF09222.5;PF00419.15 0 adhesin E1W7P9_SALTS Fimbrial subunit OS=Salmonella typhimurium (strain SL1344)\nB5R0W0_SALEP Fimbrial subunit OS=Salmonella enteritidis PT4 (strain P125109)\nF5ZRT2_SALTU Fimbrial subunit OS=Salmonella typhimurium (strain ATCC 68169 / UK-1) 0 1 Escherichia coli F17d Q47199 21658736;10384887;19580980 Enterotoxigenic E.coli Essential fimbrial adhesion factor that mediates binding to N-acetylglucosamine-containing receptors in the host intestinal microvilli leading to colonization of the intestinal tissue and diarrhea or septicemia. Also confers adhesiveness to laminin and basement membranes PF09222.5;PF05904.6;PF00419.15 0 adhesin E1W7P9_SALTS Fimbrial subunit OS=Salmonella typhimurium (strain SL1344)\nB5R0W0_SALEP Fimbrial subunit OS=Salmonella enteritidis PT4 (strain P125109)\nF5ZRT2_SALTU Fimbrial subunit OS=Salmonella typhimurium (strain ATCC 68169 / UK-1) 0 1 Escherichia coli IL-8 NP_000575 17625726;21944732;21792379 Enteropathogenic E.coli IL-8 has been implicated in induction of neutrophil to other mucosal sites during infection. PF00048.15 0 adherence "E6RWY5_CAMJS Type IV secretion system protein VirB4, putative OS=Campylobacter jejuni subsp. jejuni (strain S3)\nA1WZW8_CAMJJ CmgB3/4 OS=Campylobacter jejuni subsp. jejuni serotype O:23/36 (strain 81-176)" 3IL8 1 1 Escherichia coli saa Q3ZTY1 20223897;20103992 Enterohemorrhagic E.coli SAA binds to many Gram-negative bacteria including Escherichia coli and Pseudomonas aeruginosa through outer membrane protein A (OmpA) family members thus altered the response of innate phagocytic cells to bacteria. PF05662 0 autoagglutinating adhesin A1JM91_YERE8 Putative exported protein OS=Yersinia enterocolitica serotype O:8 / biotype 1B (strain 8081)\nB5R5C4_SALEP Putative exported protein OS=Salmonella enteritidis PT4 (strain P125109)\nE1WDB9_SALTS Autotransporter OS=Salmonella typhimurium (strain SL1344) 0 1 Escherichia coli eae CAA77642 20103992;21624114;12735346;16956777;19714857;21775541;22120799;21473096 Enteropathogenic E.coli Binding of intimin to Tir triggers dramatic intracellular changes including reorganization of cytoskeletal proteins actin polymerization at the site of intimate bacterial contact and formation of a characteristic attaching and effacing (A/E) lesion PF01476.15;PF11924.3;PF13754.1;PF02369.11;PF10670.4;PF02369.11;PF10670.4;PF02368.13;PF07979.6 0 adhesin A1JJL5_YERE8 Putative adhesin OS=Yersinia enterocolitica serotype O:8 / biotype 1B (strain 8081)\nA1JT35_YERE8 Invasin OS=Yersinia enterocolitica serotype O:8 / biotype 1B (strain 8081)\nE1WIZ3_SALTS Intimin OS=Salmonella typhimurium (strain SL1344) 4E1S 1 1 Escherichia coli iha Q6EZC5 21795517;20223897;20103992;19403767;21473096 Enterohemorrhagic E.coli It shows receptor activity and transporter activity. PF07715.2 0 transporter protein Q31T40_SHIBS Putative receptor OS=Shigella boydii serotype 4 (strain Sb227)\nE6RWJ1_CAMJS Ferric receptor CfrA OS=Campylobacter jejuni subsp. jejuni (strain S3) 0 1 Escherichia coli IL-10 NP_000563 20683261;21944732 Enteropathogenic E.coli  IL-10 facilitates the outgrowth and dissemination of bacteria during E. coli peritonitis it protects from lethality by attenuating the development of a systemic inflammatory response syndrome by a mechanism that involves inhibition of TNF release. PF00726.12 0 adhesin No Homolog Found 1TWM 1 0 Escherichia coli ureD Q8XAG3 15470125;21148732;18316019;11796646 Enterohemorrhagic E.coli It is required for maturation of urease via the functional incorporation of the urease nickel metallocenter and forms a complex that acts as a GTP-hydrolysis-dependent molecular chaperone activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. PF01774.12 0 accessory protein URED_YERE8 Urease accessory protein UreD OS=Yersinia enterocolitica serotype O:8 / biotype 1B (strain 8081)\nC3NNW1_VIBCJ Chemotaxis protein CheA OS=Vibrio cholerae serotype O1 (strain MJ-1236)\nC3LP14_VIBCM Chemotaxis protein CheA OS=Vibrio cholerae serotype O1 (strain M66-2) 0 1 Escherichia coli yjaA AAC76981 17021100;20844211 Enteropathogenic E.coli Conserved stress-induced protein function unknown; involved in peroxide and acid resistance. PF11659.3;PF00377.13 0 adhesin Q0T038_SHIF8 Rod shape-determining protein mreB OS=Shigella flexneri serotype 5b (strain 8401)\nQ31WB9_SHIBS Penicillin binding protein 3 OS=Shigella boydii serotype 4 (strain Sb227)\nE1WIF7_SALTS Rod shape-determining protein OS=Salmonella typhimurium (strain SL1344) 2DHM 1 1 Escherichia coli astA YP_003234674 20223897;17021100; 19714857 Enteropathogenic E.coli It activates guanylate cyclase resulting in ion secretion PF04958 0 toxin ASTA_SHIFL Arginine N-succinyltransferase OS=Shigella flexneri\nASTA_SHIF8 Arginine N-succinyltransferase OS=Shigella flexneri serotype 5b (strain 8401)\nASTA_SHIBS Arginine N-succinyltransferase OS=Shigella boydii serotype 4 (strain Sb227) 3BXY 1 1 Escherichia coli ibeA Q1R2H6 15817785;20974831 Enteropathogenic E.coli it is an invasion proteins which shows an oxidoreductase activity. PF12831 0 invasion protein Q83QZ7_SHIFL Putative polysaccharide export protein OS=Shigella flexneri\nQ0T369_SHIF8 Putative polysaccharide export protein OS=Shigella flexneri serotype 5b (strain 8401) 0 1 Escherichia coli AIDA-I NP_308389 1625582;20831592;12735346 Enteropathogenic E.coli Potent bacterial adhesin that mediates bacterial attachment to a broad variety of human and other mammalian cells. AIDA possesses additional virulence properties as it is capable of mediating bacterial autoaggregation via intercellular self-recognition and it is a highly efficient initiator of biofilm formation. PF13018.1;PF14250.1;PF12951.2;PF12951.2;PF05887.6;PF03797.14 0 adhesin Q0T5N3_SHIF8 Putative uncharacterized protein OS=Shigella flexneri serotype 5b (strain 8401)\nQ7UCU4_SHIFL Putative uncharacterized protein OS=Shigella flexneri\nQ83LF4_SHIFL Putative uncharacterized protein OS=Shigella flexneri 0 1 Escherichia coli EAST1 ADI59686 11243358;12735346;16956777 Enteropathogenic E.coli It activates guanylate cyclase resulting in ion secretion. PF08090.6;PF13442.1 0 toxin No Homolog Found 0 0 Escherichia coli Tia CAR20696 21775541;19940059; 10768971 Enterotoxigenic E.coli It directs noninvasive E. coli to adhere to and invade intestinal epithelial cell lines. PB016381 1 adhesin E1W8H0_SALTS Possible outer membrane adhesin OS=Salmonella typhimurium (strain SL1344)\nB5R466_SALEP Possible outer membrane adhesin OS=Salmonella enteritidis PT4 (strain P125109)\nF5ZM88_SALTU SapA-like protein OS=Salmonella typhimurium (strain ATCC 68169 / UK-1) 0 1 Escherichia coli EtpA CBL93371 21775541;19060885 Enterotoxigenic E.coli It is a large glycosylated exoprotein secreted via two-partner secretion (TPS) that promotes the intestinal colonization. PB017056 1 adhesin A1JP05_YERE8 Putative adhesin OS=Yersinia enterocolitica serotype O:8 / biotype 1B (strain 8081)\nA1VYL3_CAMJJ Putative periplasmic protein OS=Campylobacter jejuni subsp. jejuni serotype O:23/36 (strain 81-176) 1UT1 1 1 Escherichia coli Irp1 YP_853076 21775541 Enterotoxigenic E.coli IRP1 can function as an oxygen-modulated posttranscriptional regulator of gene expression. It also regulates the synthesis of proteins involved in iron homeostasis by binding to iron-responsive elements (IREs) of messenger RNA PF00109.21;PF02801.17;PF00698.16;PF08242.7;PF08659.5;PF00550.2;PF00668.15;PF08415.5 0 iron acquisition system protein A1JTF9_YERE8 Yersiniabactin biosynthetic protein OS=Yersinia enterocolitica serotype O:8 / biotype 1B (strain 8081)\nQ5CUM8_CRYPI Type I fatty acid synthase OS=Cryptosporidium parvum (strain Iowa II)\nHMWP2_YERE8 High-molecular-weight protein 2 OS=Yersinia enterocolitica serotype O:8 / biotype 1B (strain 8081)\nQ5CQX7_CRYPI Polyketide synthase OS=Cryptosporidium parvum (strain Iowa II) 0 1 Escherichia coli Irp2 YP_853075 21775541 Enterotoxigenic E.coli It is a cytoplasmictrans-regulator that modulate expression of several mRNA containing one or several regulatory sequences in their untranslated regions termed iron-responsive elements (IREs). PF00550.20;PF00668.15;PF08415.5;PF00501.23;PF08242.7;PF13193.1;PF00550.20 0 iron acquisition system protein A1JTF9_YERE8 Yersiniabactin biosynthetic protein OS=Yersinia enterocolitica serotype O:8 / biotype 1B (strain 8081)\nHMWP2_YERE8 High-molecular-weight protein 2 OS=Yersinia enterocolitica serotype O:8 / biotype 1B (strain 8081) 0 1 Escherichia coli EatA Q2VP03 21775541 Enterotoxigenic E.coli It is a autotransporter serine protease probably involved in virulence. PF03797 0 autotranspoter SEPA_SHIFL Serine protease sepA autotransporter OS=Shigella flexneri\nPIC_SHIFL Serine protease pic autotransporter OS=Shigella flexneri\nQ83JR2_SHIFL Serine protease OS=Shigella flexneri 2QOM 1 1 Escherichia coli TibA AAD41751 21775541;21216994;8675335 Enterotoxigenic E.coli It directs noninvasive E. coli to adhere to and invade intestinal epithelial cell lines. PF13018.1;PF03212.9;PF03797.14 0 adhesin Q31Z13_SHIBS Putative ATP-binding component of a transport system OS=Shigella boydii serotype 4 (strain Sb227)\nQ83KD6_SHIFL Putative ATP-binding component of a transport system OS=Shigella flexneri\nQ0T2T2_SHIF8 Putative ATP-binding component of a transport system OS=Shigella flexneri serotype 5b (strain 8401) 0 1 Escherichia coli FyuA YP_853080 21775541 Enterotoxigenic E.coli It is required for efficient biofilm formation by Escherichia coli. PF07715.10;PF00593.19 0 iron acquisition system protein FYUA_YERE8 Pesticin receptor OS=Yersinia enterocolitica serotype O:8 / biotype 1B (strain 8081)\nE1WBR8_SALTS Probable TonB-dependent receptor YncD OS=Salmonella typhimurium (strain SL1344)\nF5ZQQ7_SALTU Putative outer membrane receptor OS=Salmonella typhimurium (strain ATCC 68169 / UK-1) 0 1 Escherichia coli ECs1822 BAB35245 21317253 Enterotoxigenic E.coli It encodes hypothetical proteins of unknown function. No pfam domain found 0 toxin Q8VSB5_SHIFL IS630 ORF OS=Shigella flexneri\nQ31SL7_SHIBS IS630 ORF OS=Shigella boydii serotype 4 (strain Sb227)\nQ8VSK9_SHIFL IS630 ORF OS=Shigella flexneri\nF5ZZR4_SALTU Putative integrase protein OS=Salmonella typhimurium (strain ATCC 68169 / UK-1) 0 1 Escherichia coli nleH BAF96518 21317253;20223805 Enteropathogenic E.coli It is an autophosphorylated Ser/Thr protein kinase and plays an important role in the colonization of animal hosts and in altering NF-kB activity. PF10707.4 0 toxin A1JRU6_YERE8 Putative exported protein OS=Yersinia enterocolitica serotype O:8 / biotype 1B (strain 8081)\nA1JRY5_YERE8 Putative type III secreted effector protein OS=Yersinia enterocolitica serotype O:8 / biotype 1B (strain 8081)\nOSPG_SHIFL Protein kinase OspG OS=Shigella flexneri 0 1 Escherichia coli nleA BAF96541 21317253;21326920;21473096 Enterohemorrhagic E.coli Co-localises with the Golgi mannosidase II when translocated by bacteria funcion unknown. PB006720 1 toxin C9YNI8_CLODR Putative germination-specific protease OS=Clostridium difficile (strain R20291)\nC9XL42_CLODC Putative germination-specific protease OS=Clostridium difficile (strain CD196) 0 1 Escherichia coli nleC EHW95029 21317253 Enterohemorrhagic E.coli It plays a role in cytoskeletal rearrangement. PF13678.1 0 toxin F5ZUX3_SALTU Putative uncharacterized protein OS=Salmonella typhimurium (strain ATCC 68169 / UK-1)\nQ5CV59_CRYPI Ser/Thr protein kinase OS=Cryptosporidium parvum (strain Iowa II)\nA1JHU9_YERE8 LuxR family transcription regulatory protein OS=Yersinia enterocolitica serotype O:8 / biotype 1B (strain 8081) 0 1 Escherichia coli nleG BAF96522 21317253 Enterohemorrhagic E.coli It selectively interact with human E2 ubiquitin conjugating enzymes and exhibit in vitro activity typical of eukaryotic E3 ligases. PF06416.7 0 toxin "A3FPW8_CRYPI Kinesin-like boursin, putative OS=Cryptosporidium parvum (strain Iowa II)" 0 1 Escherichia coli nleG2 2KKY_A 21317253 Enterohemorrhagic E.coli It selectively interact with human E2 ubiquitin conjugating enzymes and exhibit in vitro activity typical of eukaryotic E3 ligases. PF06416 0 toxin No Homolog Found 2KKY 1 0 Escherichia coli espJ BAF96525 21317253;21473096 Enterohemorrhagic E.coli EspJ is a protein responsible for trans-inhibition of macrophage opsono-phagocytosis by both EPEC and EHEC. PF09143.5;PF11782.3 0 toxin "Q5CSJ4_CRYPI Eukaryotic orthologous group, signal peptide OS=Cryptosporidium parvum (strain Iowa II)\nE1W8A6_SALTS Lysine decarboxylase OS=Salmonella typhimurium (strain SL1344)\nQ183L3_CLOD6 Putative glycosyl transferase, family 2 OS=Clostridium difficile (strain 630)\nC9YPZ9_CLODR Putative glycosyl transferase OS=Clostridium difficile (strain R20291)\nC9XP80_CLODC Putative glycosyl transferase OS=Clostridium difficile (strain CD196)" 0 1 Escherichia coli espM2 EHV23605 21317253 Enterohemorrhagic E.coli EspM2 might play a role in maintaining tight junctions during infection. It might modulate additional cellular pathways. PF03278.8 0 toxin No Homolog Found 0 0 Escherichia coli nleG8-2 CBG90798 21317253 Enterohemorrhagic E.coli It selectively interact with human E2 ubiquitin conjugating enzymes and exhibit in vitro activity typical of eukaryotic E3 ligases. PF06416 0 toxin SYI_AERHH Isoleucine--tRNA ligase OS=Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / NCIB 9240)\nXYLA_YERE8 Xylose isomerase OS=Yersinia enterocolitica serotype O:8 / biotype 1B (strain 8081)\nC3NX10_VIBCJ Putative uncharacterized protein OS=Vibrio cholerae serotype O1 (strain MJ-1236) 0 1 Escherichia coli espG AAL57583 21317253 Enteropathogenic E.coli It is predicted to encode a 44-kDa 398-amino-acid protein that is highly conserved between the LEE of EPEC strain E2348/69 and other attaching-effacing pathogens including enterohemorrhagic E. coli (EHEC) O157:H7 PF06872.6 0 toxin VIRA_SHIFL Cysteine protease-like virA OS=Shigella flexneri\nMLAA_SHIFL Probable phospholipid-binding lipoprotein mlaA OS=Shigella flexneri\nQ0T2E1_SHIF8 Lipoprotein OS=Shigella flexneri serotype 5b(strain 8401) 3Q1C 1 1 Escherichia coli espL2 YP_003224735 21317253;20675003 Enteropathogenic E.coli EspL2 supports efficient colonization by increasing annexin 2's ability to aggregate Tir-induced F-actin and by modifying the morphology of the host cell membrane. PF07906.8;PF08606.6 0 toxin Q99Q01_SHIFL Putative uncharacterized protein ospD3 OS=Shigella flexneri\nQ31SL0_SHIBS OspD3 OS=Shigella boydii serotype 4 (strain Sb227)\nQ8VSQ0_SHIFL Putative uncharacterized protein ospD2 OS=Shigella flexneri 0 1 Escherichia coli nleB YP_003498582 20090843;21317253;20844211;20675003;21473096 Enterohemorrhagic E.coli nleB encodes an important virulence determinant of attaching and effacing (A/E) pathogens. PB000694 1 toxin E1WEK1_SALTS Type III secretion system effector protein OS=Salmonella typhimurium (strain SL1344)\nB5QYE2_SALEP Putative uncharacterized protein OS=Salmonella enteritidis PT4 (strain P125109)\nF5ZWQ8_SALTU Putative cytoplasmic protein OS=Salmonella typhimurium (strain ATCC 68169 / UK-1)\nE1WGN6_SALTS Type III secretion system effector protein OS=Salmonella typhimurium (strain SL1344)\nB5QY38_SALEP Phage protein OS=Salmonella enteritidis PT4(strain P125109) 0 1 Escherichia coli nleE YP_003223427 19815525;21317253;20675003;14982621 Enterohemorrhagic E.coli It is important for inhibition of NF-KB activation. PF05798.6 0 toxin Q31SD9_SHIBS Putative uncharacterized protein OS=Shigella boydii serotype 4 (strain Sb227)\nE1WH23_SALTS Dehydratase OS=Salmonella typhimurium (strain SL1344)\nF5ZSQ8_SALTU CDP-6-deoxy-D-xylo-4-hexulose-3-dehydrase OS=Salmonella typhimurium (strain ATCC 68169 / UK-1) 0 1 Escherichia coli toxB ACJ71246 21795517 Enterohemorrhagic E.coli Important for full expression of adherence by affecting the production and secretion of some virulence factors required for the development of A/E lesions. PF12919.2;PF11996.3 0 adhesin C9YJ35_CLODR Toxin B OS=Clostridium difficile (strain R20291)\nC9XKU6_CLODC Toxin B OS=Clostridium difficile (strain CD196)\nQ189K3_CLOD6 Toxin B OS=Clostridium difficile (strain 630) 0 1 Escherichia coli efa1 AAL57562 19403767;20844211;21473096 Enterohemorrhagic E.coli It inhibits lymphocyte activation and actins as adhesin in non-O157:H7 EHEC strains. PF12918.2;PF12919.2;PF11996.3 0 adhesin Q189K3_CLOD6 Toxin B OS=Clostridium difficile (strain 630)\nC9YJ35_CLODR Toxin B OS=Clostridium difficile (strain R20291)\nC9XKU6_CLODC Toxin B OS=Clostridium difficile (strain CD196)\nQ189K5_CLOD6 Toxin A OS=Clostridium difficile (strain 630) 0 1 Escherichia coli tir ABE65381 14982621 ;21624114;17887989 Enterohemorrhagic E.coli It acts as receptor for intimin Nucleation of cytoskeletal proteins loss of microvilli GAP (GTPase-activating protein)-like activity PF07490.6;PF03549.9;PF07489.6 0 adhesin No Homolog Found 2ZWK 1 0 Escherichia coli TccP Q8X482 21624114 Enterohemorrhagic E.coli It is required for efficient pedestal formation in host epithelial cells during infection. Acts as an intermediate between Tir (via host BAIAP2) and host WASL/N-WASP. Directly binds and activates WASL/N-WASP which stimulates actin polymerization and leads to the formation of actin pedestals at the sites of bacterial adhesion. PF04806.7;PF07527.8;PF04806.7 0 adhesin No Homolog Found 0 0 Escherichia coli Stx1 ACI22418 21658736;17716835;15992278;22120799;21473096 Enterohemorrhagic E.coli It is a Shiga toxin producing E.coli which is an important factor in disease pathogenesis and is responsible for the haemolytic uremic syndrome (HUS). PF00161.14 0 toxin C9YKY5_CLODR Putative esterase OS=Clostridium difficile (strain R20291)\nC9XPQ8_CLODC Putative esterase OS=Clostridium difficile (strain CD196)\nA1JI30_YERE8 ABC transporter protein OS=Yersinia enterocolitica serotype O:8 / biotype 1B (strain 8081) 1R4Q 1 1 Escherichia coli Stx2 ADK02660 21658736;17716835;15992278;22120799;21473096 Enterohemorrhagic E.coli It is a Shiga toxin producing E.coli which is an important factor in disease pathogenesis and is responsible for the haemolytic uremic syndrome (HUS). PB009729 1 toxin Q83II2_SHIFL Putative uncharacterized protein yjiA OS=Shigella flexneri\nQ31SZ4_SHIBS Putative uncharacterized protein yjiA OS=Shigella boydii serotype 4 (strain Sb227)\nQ0SX70_SHIF8 Putative uncharacterized protein yjiA OS=Shigella flexneri serotype 5b (strain 8401) 1R4P 1 1 Escherichia coli EspA AAK26727 14982621; 22493278;22403793;21473096 Enterohemorrhagic E.coli It is a component of an extracellular type III translocation apparatus and Forms filamentous structure on the bacterial surface during the early stage of A/E lesion formation forms a physical bridge between the bacterium and the infected eukaryotic cell surface and is required for the translocation of EspB and EspD. PF03433.8;PF14160.1;F01232.18;PF09748.4;PF07972.6 0 transporter protein E1WFR4_SALTS Type III secretion system secreted effector protein OS=Salmonella typhimurium (strain SL1344)\nB5QV59_SALEP Putative pathogenicity island effector effector protein OS=Salmonella enteritidis PT4 (strain P125109)\nF5ZPH8_SALTU Enhanced serine sensitivity protein SseB OS=Salmonella typhimurium (strain ATCC 68169 / UK-1) 1XOU 1 1 Escherichia coli EspB AAK49184 22403793;14982621 Enteropathogenic E.coli EspB transit through the EspA filament to form a pore or translocon with EspD in the host plasma membrane to deliver other effectors into the cell and perhaps act as translocated effectors themselves PF05802.6 0 transporter protein No Homolog Found 2LHK 1 0 Escherichia coli EspD AAK26728 22403793;22493278 Enteropathogenic E.coli EspD transit through the EspA filament to form a pore or translocon with EspB in the host plasma membrane to deliver other effectors into the cell and perhaps act as translocated effectors themselves PF04888.7;PF14038.1;PF14242.1 0 transporter protein A8FLG9_CAMJ8 Putative uncharacterized protein OS=Campylobacter jejuni subsp. jejuni serotype O:6 (strain 81116 / NCTC 11828)\nQ0Q7L0_CAMJJ Putative uncharacterized protein OS=Campylobacter jejuni subsp. jejuni serotype O:23/36 (strain 81-176)\nE1WJI2_SALTS Predicted bacteriophage protein OS=Salmonella typhimurium (strain SL1344) 3GOK 1 1 Escherichia coli AfaE-VIII ADD91746 19067217 Enteropathogenic E.coli It mediates the adherence of uropathogenic and diarrhea-associated Escherichia coli to various host tissues. PF09460.5 0 adhesin "E6RSV6_CAMJS Putative type IIS restriction /modification enzyme, N-terminal protein OS=Campylobacter jejuni subsp. jejuni (strain S3)\nQ5CSE3_CRYPI Splicing factor U2AF like SnRNP auxilary factor large subunit, RRM domain (Fragment) OS=Cryptosporidium parvum (strain Iowa II)" 0 1 Escherichia coli bfpA AAC44040 19714857;22120799 Enteropathogenic E.coli It serves as initial attachment factors in atypical EPEC. PF05307.6;PF12304.3 0 adhesin "B5QYU1_SALEP Putative type IV pilin OS=Salmonella enteritidis PT4 (strain P125109)\nQ5CQG8_CRYPI DNA topoisomerase 2 OS=Cryptosporidium parvum (strain Iowa II)\nE6RUC0_CAMJS Capsular polysaccharide ABC transporter, ATP-binding protein KpsT OS=Campylobacter jejuni subsp. jejuni (strain S3)" 1ZWT 1 1 Escherichia coli EspF AAK26733 21326920 Enteropathogenic E.coli A bacterial effector of the reduction in tight junction integrity by inducing redistribution of the tight-junction-associated protein occludin PF04806.7 0 toxin No Homolog Found 2K42 1 0 Escherichia coli cba ADL13938 21473096 Enterohemorrhagic E.coli This colicin is a channel-forming colicin. This class of transmembrane toxins depolarize the cytoplasmic membrane leading to dissipation of cellular energy. PF03515.9;PF01024.14 0 transmembrane toxin "Q5CR87_CRYPI GNog1p. GTpase (Fragment) OS=Cryptosporidium parvum (strain Iowa II)\nA1JIT5_YERE8 2',3'-cyclic-nucleotide 2'-phosphodiesterase OS=Yersinia enterocolitica serotype O:8 / biotype 1B (strain 8081)\nA1JTJ6_YERE8 Putative binding protein-dependent transport system, inner-membrane component OS=Yersinia enterocolitica serotype O:8 / biotype 1B (strain 8081)" 0 1 Escherichia coli sepA CAA90179 7644527;20075111;17714480 Enteropathogenic E.coli sepA mutant exhibited an attenuated virulence which suggests that SepA might play a role in tissue invasion. PF00771.15 0 invasion protein E1WFT0_SALTS Type III secretion system apparatus OS=Salmonella typhimurium (strain SL1344)\nB5QV43_SALEP Putative type III secretion protein OS=Salmonella enteritidis PT4 (strain P125109)\nF5ZPJ4_SALTU Secretion system apparatus protein SsaVOS=Salmonella typhimurium (strain ATCC 68169 / UK-1) 0 1 Escherichia coli sepB CAA90180 21550373;7644527;17714480 Enteropathogenic E.coli It is a component of a type III secretory apparatus necessary for the export of virulence determinants. PF00006.20 0 invasion protein E1WFT1_SALTS Type III secretion ATP synthase OS=Salmonella typhimurium (strain SL1344)\nF5ZPJ5_SALTU Type III secretion system ATPase OS=Salmonella typhimurium (strain ATCC 68169 / UK-1)\nB5QV42_SALEP Putative type III secretion ATP synthase OS=Salmonella enteritidis PT4 (strain P125109)\nQ87P50_VIBPA ATP synthase in type III secretion system OS=Vibrio parahaemolyticus 0 1 Escherichia coli sepC CAA90274 17714480;7644527 Enteropathogenic E.coli It is a component of a type III secretory apparatus necessary for the export of virulence determinants. PF03958.12;PF00263.16 0 invasion protein E1WFR0_SALTS Outer membrane secretory protein OS=Salmonella typhimurium (strain SL1344)\nF5ZPH4_SALTU Outer membrane secretin OS=Salmonella typhimurium (strain ATCC 68169 / UK-1)\nB5QV63_SALEP Putative outer membrane secretory protein OS=Salmonella enteritidis PT4 (strain P125109) 0 1 Escherichia coli sepD CAA90273 17097322;7644527 Enteropathogenic E.coli It is a component of a type III secretory apparatus necessary for the export of virulence determinants. PB012777 1 invasion protein "Q18AU2_CLOD6 Integrase Tn1549-like, CTn4-Orf34 OS=Clostridium difficile (strain 630)" 0 1 Campylobacter jejuni flaB P56964 11298288 Campylobacter jejuni (i)It helps in penetrating the mucus barrier. (ii) leads to intestinal colonization (iii) PF00669.15;PF07196.8;PF05384.6;PF00700.16;PF11570.3 0 invasion protein FLAF_VIBPA Polar flagellin F OS=Vibrio parahaemolyticus\nC3NNN5_VIBCJ Flagellin protein FlaF OS=Vibrio cholerae serotype O1 (strain MJ-1236)\nC3LPE9_VIBCM Flagellin FlaE OS=Vibrio cholerae serotype O1 (strain M66-2)\nFLAE_VIBC3 Flagellin E OS=Vibrio cholerae serotype O1 (strain ATCC 39541 / Ogawa 395 / O395)\nA0KIY3_AERHH Flagellin OS=Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / NCIB 9240)\nC3NNN7_VIBCJ Flagellin B OS=Vibrio cholerae serotype O1 (strain MJ-1236) 1CIV 1 1 Campylobacter jejuni flaA P56963 11298288 Campylobacter jejuni (i)It helps in penetrating the mucus barrier. (ii) leads to intestinal colonization (iii) PF00669.15;PF07196.8;PF05384.6;PF00700.16 0 invasion protein C3NNN5_VIBCJ Flagellin protein FlaF OS=Vibrio cholera serotype O1 (strain MJ-1236)\nC3LPE9_VIBCM Flagellin FlaE OS=Vibrio cholerae serotype O1 (strain M66-2)\nFLAE_VIBC3 Flagellin E OS=Vibrio cholerae serotype O1 (strain ATCC 39541 / Ogawa 395 / O395)\nFLAF_VIBPA Polar flagellin F OS=Vibrio parahaemolyticus 2GN4 1 1 Campylobacter jejuni flaC YP_001000416 15228533 Campylobacter jejuni It helps in cell invasion. PF00700 0 invasion protein FLAA_VIBPA Polar flagellin A OS=Vibrio parahaemolyticus\nQ18CX7_CLOD6 Flagellin C OS=Clostridium difficile (strain 630)\nFLAL_VIBPA Lateral flagellin OS=Vibrio parahaemolyticus\nA0KIY3_AERHH Flagellin OS=Aeromonas hydrophila subsp.hydrophila (strain ATCC 7966 / NCIB 9240)\nD3GSB5_ECO44 Lateral flagellar flagellin (FliC-like) OS=Escherichia coli O44:H18 (strain 042 / EAEC) 1KF0 1 1 Campylobacter jejuni cdtA AAF16678 17353111;17274298 Campylobacter jejuni It may acts directly on enterocytes to induce host cell cycle arrest distension and proinflammatory cytokine induction or may act on immune cells such as intraepithelial lymphocytes to cause cell cycle arrest. PF03498.9 0 toxin 5CY08_CRYPI Extracellular protein with a signal peptide followed by family 2 glycosyltransferase and ricin domains OS=Cryptosporidium parvum (strain Iowa II) 0 1 Campylobacter jejuni cdtB AAF16679 17353111;17274298 Campylobacter jejuni It may acts directly on enterocytes to induce host cell cycle arrest distension and proinflammatory cytokine induction or may act on immune cells such as intraepithelial lymphocytes to cause cell cycle arrest. PF03372.18 0 toxin No Homolog Found 2F1N 1 0 Campylobacter jejuni cdtC Q46101 17353111;17274298 Campylobacter jejuni It may acts directly on enterocytes to induce host cell cycle arrest distension and proinflammatory cytokine induction or may act on immune cells such as intraepithelial lymphocytes to cause cell cycle arrest. PF03372 0 toxin No Homolog Found 2F1N 1 0 Campylobacter jejuni cadF NP_282616 12438340;12576589 Campylobacter jejuni It mediates the binding of the organism to the extracellular matrix component fibronectin which in turn stimulates a signal transduction pathway. PF13505 0 adhesin protein C3NND3_VIBCJ Outer membrane protein A OS=Vibrio cholerae serotype O1 (strain MJ-1236)\nC3LPL7_VIBCM Outer membrane protein OmpA OS=Vibrio cholerae serotype O1 (strain M66-2)\nA5F648_VIBC3 Outer membrane protein OmpA OS=Vibrio cholerae serotype O1 (strain ATCC 39541 / Ogawa 395 / O395)\nQ87RL4_VIBPA Outer membrane protein OmpA OS=Vibrio parahaemolyticus 3M7P 1 1 Campylobacter jejuni Cj1415c NP_282556 10688204;1332767 Campylobacter jejuni It plays an important role in bacterial survival and persistance in the enviroment and evasion of host immune response. The presence of heptose residues in the capsule may be important for virulence. Heptose residues found in some cell surface-located glycoconjugates are required for adhesion PF01583 0 adhesin A0KQM9_AERHH Adenylyl-sulfate kinase OS=Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / NCIB 9240)\nCYSC_AERHH Adenylyl-sulfate kinase OS=Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / NCIB 9240)\nCYSC_VIBPA Adenylyl-sulfate kinase OS=Vibrio parahaemolyticus\nC3NV51_VIBCJ Adenylyl-sulfate kinase OS=Vibrio cholerae serotype O1 (strain MJ-1236) 0 1 Campylobacter jejuni Cj1416c NP_282557 15612919;10688204;10672176 Campylobacter jejuni It plays an important role in bacterial survival and persistance in the enviroment and evasion of host immune response. The presence of heptose residues in the capsule may be important for virulence. Heptose residues found in some cell surface-located glycoconjugates are required for adhesion PF00483 0 adhesin Q5CTS3_CRYPI Mannose-1-phosphate guanylyltransferase OS=Cryptosporidium parvum (strain Iowa II)\nQ18CV4_CLOD6 CTP:phosphocholine cytidylyltransferase OS=Clostridium difficile (strain 630)\nQ87T33_VIBPA UTP-glucose-1-phosphate uridylyltransferase OS=Vibrio parahaemolyticus\nA0KQM9_AERHH Adenylyl-sulfate kinase OS=Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / NCIB 9240) 0 1 Campylobacter jejuni Cj1421c Q0P8J3 10688204;10672176 Campylobacter jejuni It plays an important role in bacterial survival and persistance in the enviroment and evasion of host immune response. The presence of heptose residues in the capsule may be important for virulence. Heptose residues found in some cell surface-located glycoconjugates are required for adhesion PF11186.1 0 adhesin D3GR83_ECO44 Putative fimbrial protein OS=Escherichia coli O44:H18 (strain 042 / EAEC) 0 1 Campylobacter jejuni kpsM NP_282588 10672176;12392544;7715449 Campylobacter jejuni It plays an important role in bacterial survival and persistance in the enviroment and evasion of host immune response. The presence of heptose residues in the capsule may be important for virulence. Heptose residues found in some cell surface-located glycoconjugates are required for adhesion PF01061.1 0 adhesin D3GUV0_ECO44 Polysialic acid transport permease protein OS=Escherichia coli O44:H18 (strain 042 / EAEC) 1KOP 1 1 Campylobacter jejuni kpsS NP_282554 10672176;10688204 Campylobacter jejuni It plays an important role in bacterial survival and persistance in the enviroment and evasion of host immune response. The presence of heptose residues in the capsule may be important for virulence. Heptose residues found in some cell surface-located glycoconjugates are required for adhesion PF05159.1 0 adhesin D3GUU5_ECO44 Capsule polysaccharide export protein OS=Escherichia coli O44:H18 (strain 042 / EAEC)\nQ87T98_VIBPA Putative binding protein component of ABC transporter OS=Vibrio parahaemolyticus 1C5W 1 1 Campylobacter jejuni kpsC NP_282555 10672176;10688204 Campylobacter jejuni It plays an important role in bacterial survival and persistance in the enviroment and evasion of host immune response. The presence of heptose residues in the capsule may be important for virulence. Heptose residues found in some cell surface-located glycoconjugates are required for adhesion PF05159.1 0 adhesin D3GUU5_ECO44 Capsule polysaccharide export protein OS=Escherichia coli O44:H18 (strain 042 / EAEC)\nQ5CWJ7_CRYPI Putative uncharacterized protein OS=Cryptosporidium parvum (strain Iowa II) 1FS1 1 1 Campylobacter jejuni kpsD NP_282585 10672176;10688204 Campylobacter jejuni It plays an important role in bacterial survival and persistance in the enviroment and evasion of host immune response. The presence of heptose residues in the capsule may be important for virulence. Heptose residues found in some cell surface-located glycoconjugates are required for adhesion PF10531.1 0 adhesin D3GUU5_ECO44 Capsule polysaccharide export protein OS=Escherichia coli O44:H18 (strain 042 / EAEC)\nQ87T50_VIBPA OtnA protein OS=Vibrio parahaemolyticus\nQ87FS6_VIBPA Capsular polysaccharide transport protein OS=Vibrio parahaemolyticus\nQ31YP6_SHIBS Putative function in exopolysaccharide production OS=Shigella boydii serotype 4 (strain Sb227) 2GQJ 1 1 Campylobacter jejuni kpsE NP_282586 10672176;10688204 Campylobacter jejuni It plays an important role in bacterial survival and persistance in the enviroment and evasion of host immune response. The presence of heptose residues in the capsule may be important for virulence. Heptose residues found in some cell surface-located glycoconjugates are required for adhesion PF02706.1 0 adhesin "D3GUU1_ECO44 Capsule polysaccharide export protein OS=Escherichia coli O44:H18 (strain 042 / EAEC)\nQ87PN9_VIBPA Putative polysaccharide export protein OS=Vibrio parahaemolyticus\nA3FPT0_CRYPI DNAJ protein-like, putative OS=Cryptosporidium parvum (strain Iowa II)" 1BIG 1 1 Campylobacter jejuni kpsF NP_282584 10672176;10688204 Campylobacter jejuni It plays an important role in bacterial survival and persistance in the enviroment and evasion of host immune response. The presence of heptose residues in the capsule may be important for virulence. Heptose residues found in some cell surface-located glycoconjugates are required for adhesion PF01380.2;PF00571.1 0 adhesin A0KQ16_AERHH Arabinose 5-phosphate isomerase OS=Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / NCIB 9240)\nQ87LE6_VIBPA Putative polysialic acid capsule expression protein OS=Vibrio parahaemolyticus\nA5F5C2_VIBC3 Arabinose 5-phosphate isomerase OS=Vibrio cholerae serotype O1 (strain ATCC 39541 / Ogawa 395 /O395)\nC3NV82_VIBCJ Arabinose 5-phosphate isomerase OS=Vibrio cholerae serotype O1 (strain MJ-1236) 1NM6 1 1 Campylobacter jejuni fcI NP_282569 10688204 Campylobacter jejuni It plays an important role in bacterial survival and persistance in the enviroment and evasion of host immune response. The presence of heptose residues in the capsule may be important for virulence. Heptose residues found in some cell surface-located glycoconjugates are required for adhesion PF13458 0 adhesin B5YUB0_ECO5E GDP-L-fucose synthetase OS=Escherichia coli O157:H7 (strain EC4115 / EHEC)\nC6V0L1_ECO5T Bifunctional GDP-fucose synthetase:GDP-4-dehydro-6-deoxy-D-mannose epimerase and GDP-4-dehydro-6-L-deoxygalactose reductase OS=Escherichia coli O157:H7 (strain TW14359 / EHEC)\nD3GZB4_ECO44 GDP-L-fucose synthetase OS=Escherichia coli O44:H18 (strain 042 / EAEC)\n|Q83QZ9_SHIFL Putative nucleotide di-P-sugar epimerase or dehydratase OS=Shigella flexneri 0 1 Campylobacter jejuni glf NP_282580 12392544 Campylobacter jejuni It plays an important role in bacterial survival and persistance in the enviroment and evasion of host immune response. The presence of heptose residues in the capsule may be important for virulence. Heptose residues found in some cell surface-located glycoconjugates are required for adhesion PF03275.1 0 adhesin "F5ZND9_SALTU Putative UDP-galactopyranose mutase OS=Salmonella typhimurium (strain ATCC 68169 / UK-1)\nA0KLA6_AERHH Amine oxidase, flavin-containing superfamily OS=Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / NCIB 9240)\nB5QVU9_SALEP Putative electron transfer flavoprotein-quinone oxidoreductase OS=Salmonella enteritidis PT4 (strain P125109)" 3GF4 1 1 Campylobacter jejuni kpsT NP_282587 10672176;7715449 Campylobacter jejuni It plays an important role in bacterial survival and persistance in the enviroment and evasion of host immune response. The presence of heptose residues in the capsule may be important for virulence. Heptose residues found in some cell surface-located glycoconjugates are required for adhesion PF01926.1 0 adhesin No Homolog Found 0 0 Campylobacter jejuni JlpA NP_282133 12614460 Campylobacter jejuni JlpA of Campylobacter jejuni interacts with surface-exposed heat shock protein 90alpha and triggers signalling pathways leading to the activation of NF-kappaB and p38 MAP kinase in epithelial cells. PF02119 0 adhesin A1JQR6_YERE8 AraC-family regulatory protein OS=Yersinia enterocolitica serotype O:8 / biotype 1B (strain 8081)\nB5QZ00_SALEP Probable AraC-family trancriptional regulatory protein OS=Salmonella enteritidis PT4 (strain P125109)\nE1WHV1_SALTS Probable AraC-family trancriptional regulatory protein OS=Salmonella typhimurium (strain SL1344) 0 1 Campylobacter jejuni TetO AAA23033 10899834;2836268 Campylobacter jejuni It abolishes the inhibitory effect of tetracyclin on protein synthesis by a non-covalent modification of the ribosomes. PF00009.22;PF03144.20;PF03764.13;PF00679.19 0 adhesin Q188V1_CLOD6 Tetracycline resistance protein Tn5397 OS=Clostridium difficile (strain 630)\nC9YHM3_CLODR Elongation factor G OS=Clostridium difficile (strain R20291)\nC9XII7_CLODC Elongation factor G OS=Clostridium difficile (strain CD196)\nEFG_CLOD6 Elongation factor G OS=Clostridium difficile (strain 630)\nEFG2_VIBPA Elongation factor G 2 OS=Vibrio parahaemolyticus\nC3NVQ2_VIBCJ Elongation factor G 2 OS=Vibrio cholera serotype O1 (strain MJ-1236) 0 1 Campylobacter jejuni CgtA ABK63954 11796612 Campylobacter jejuni It encodes an N-acetylgalactosaminyl (GalNAc) transferase results in changes in the major core structure from GM2 to GM3 ganglioside mimicry. Insertional inactivation of the cgtA gene results in a mutant lacking GM2 mimicry and this mutant shows enhanced invasion of intestinal epithelial cells. PF06306.6 0 adhesin Q185A3_CLOD6 Putative uncharacterized protein OS=Clostridium difficile (strain 630)\nC9XR81_CLODC Putative uncharacterized protein OS=Clostridium difficile (strain CD196)\nC9YQZ9_CLODR Putative uncharacterized protein OS=Clostridium difficile (strain R20291) 3G2C 1 1 Campylobacter jejuni porA AAC82317 9435102 Campylobacter jejuni A putative porin and a multifuction surface protein may play an important role in adherence. PF05538.6 0 adhesin Q322N0_SHIBS Flagellin OS=Shigella boydii serotype 4 (strain Sb227)\nA0KN33_AERHH Type IV pilus biogenesis PilN OS=Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / NCIB 9240) 3K19 1 1 Campylobacter jejuni PEB1 YP_002344319 16689801;9488379 Campylobacter jejuni Cell-binding factor enhancing bacterial adherence to and invasion of host cells. PF00497.15 0 adhesin "A0KGB4_AERHH Glutamine/glutamate ABC transporter, periplasmic glutamine/glutamate-binding protein OS=Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / NCIB 9240)\nB7L8T3_ECO55 Cystine transporter subunit\nperiplasmic-binding component of ABC superfamily OS=Escherichia coli (strain 55989 / EAEC)\nC8UC91_ECO1A Putative periplasmic binding transporter protein FliY OS=Escherichia coli O111:H- (strain 11128 /EHEC)" 0 1 Campylobacter jejuni ciaB NP_282066 10361274 Campylobacter jejuni It is required for maximal invasion of intestinal epithelial cells. PF13079.1 0 invasion protein "C3NNU8_VIBCJ Ferrous iron transport protein B OS=Vibrio cholerae serotype O1 (strain MJ-1236)\nC3LP27_VIBCM Ferrous iron transport protein B OS=Vibrio cholerae serotype O1 (strain M66-2)\nA5F6H6_VIBC3 Ferrous iron transport protein B OS=Vibrio cholerae serotype O1 (strain ATCC 39541 / Ogawa 395 / O395)\nC9XQ69_CLODC PTS system, glucose-specific IIa component OS=Clostridium difficile (strain CD196)\nA1JJL5_YERE8 Putative adhesin OS=Yersinia enterocolitica serotype O:8 / biotype 1B (strain 8081)" 0 1 Shigella flexneri 2a H-NS NP_836928 7691791;21724612 Shigella flexneri 2a H-NS binds tightly to ds-DNA increases its thermal stability and inhibits transcription. It also binds to ss-DNA and RNA but with a much lower affinity. H-NS has possible histone-like function. May be a global transcriptional regulator through its ability to bind to curved DNA sequences which are found in regions upstream of a certain subset of promoters. It plays a role in the thermal control of pili production. It is subject to transcriptional auto-repression. It binds preferentially to the upstream region of its own gene recognizing two segments of DNA on both sides of a bend centered around -150. PF04632.7;PF08286.6 0 binding protein B5YYE2_ECO5E DNA-binding protein H-NS OS=Escherichia coli O157:H7 (strain EC4115 / EHEC)\nC6US50_ECO5T Global DNA-binding transcriptional dual regulator H-NS OS=Escherichia coli O157:H7 (strain TW14359 / EHEC)\nB7UQC9_ECO27 Global DNA-binding transcriptional dual egulator H-NS OS=Escherichia coli O127:H6 (strain E2348/69 / EPEC)\nD3H2L9_ECO44 DNA-binding protein (Histone-like protein Hlp-II) OS=Escherichia coli O44:H18 (strain 042 / EAEC)\nE1WFZ1_SALTS H-NS DNA-binding protein (Histone-like protein Hlp-II) OS=Salmonella typhimurium (strain SL1344) 1NI8 1 1 Shigella flexneri 2a ShET-2 NP_001139746  10523561;21219446 Shigella flexneri 2a It may account for the early diarrheal phase often observed during shigellosis. PF08347.1;PF00505.1 0 toxin No Homolog Found 0 0 Shigella flexneri 2a IpaA NP_085287 17088427;21525010 Shigella flexneri 2a Rapidly associates with the first 265 amino acids of vinculin after bacteria-cell contact. This interaction is critical for efficient Shigella uptake. IpaA acts as a potent activator of vinculin and increase its ability to interact with F-actin. The complex ipaA-vinculin induces F-actin depolymerization along with the occasional formation of actin filament bundles PF09052.5 0 invasion protein B5QVD0_SALEP Putative uncharacterized protein sipA OS=Salmonella enteritidis PT4 (strain P125109)\nSIPA_SALTS Cell invasion protein sipA OS=Salmonella typhimurium (strain SL1344)\nF5ZV96_SALTU Secreted effector protein OS=Salmonella typhimurium (strain ATCC 68169 / UK-1)\nB7UR42_ECO27 Predicted portal protein OS=Escherichia coli O127:H6 (strain E2348/69 / EPEC)\nC8UPF8_ECO1A Putative portal protein OS=Escherichia coli O111:H- (strain 11128 / EHEC) 3RF3 1 1 Shigella flexneri 2a IpaB NP_085290 21525010 Shigella flexneri 2a Forms a pore with ipaC which is inserted into the host cell membrane through the Mxi/Spa apparatus during cell contact. This pore probably allows the translocation of ipaA. IpaB has also been found to be necessary and sufficient to activate macrophage apoptosis by binding to interleukin-1 beta converting enzyme (ICE). Has also been shown to be important along with ipaD to block or regulate secretion through the Mxi/Spa translocon in the presence or absence of the secretion signal respectively. Through interaction with host human MAD2L2 constitutively activates the anaphase-promoting complex APC and induces a cell cycle arrest to prevent epithelial renewal in order to promote bacterial colonization. PF04888.7;PF13083.1 0 invasion protein E1WAC9_SALTS Pathogenicity island 1 Type III secretion system effector protein OS=Salmonella typhimurium (strain SL1344)\nB5QVD3_SALEP Pathogenicity island 1 effector protein OS=Salmonella enteritidis PT4 (strain P125109)\nF5ZV99_SALTU Translocation machinery component OS=Salmonella typhimurium (strain ATCC 68169 / UK-1)\nD3H2F4_ECO44 Putative cell invasion type III effector protein OS=Escherichia coli O44:H18 (strain 042 / EAEC)\nQ87TA3_VIBPA Putative uncharacterized protein VP0167 OS=Vibrio parahaemolyticus 3GZ2 1 1 Shigella flexneri 2a ipaH Q0T5L0 16822325 Shigella flexneri 2a It facilitates the escape of the bacteria from phagocytic vacuole of macrophages. PF13855.1 0 invasion protein "D3H1Y8_ECO44 Putative type III effector protein (Leucine-rich repeat protein) OS=Escherichia coli O44:H18 (strain 042 / EAEC)\nE1W9T7_SALTS Type III secretion system effector protein, leucine rich repeat-Acts as a ubiquitin ligase for thioredoxin. Also targets the ERdj3 chaperone of mammalian cells OS=Salmonella typhimurium (strain SL1344)\nA1JU68_YERE8 Yop type III secretion system effector protein OS=Yersinia enterocolitica serotype O:8 / biotype 1B (strain 8081)\nE1WC83_SALTS Type III secretion system effector protein-E3 Ubiquitin ligase OS=Salmonella typhimurium (strain SL1344)" 3CKD 1 1 Shigella flexneri 2a icsA Q326N1 9352898;21724612 Shigella flexneri 2a It mediates intracellular movement and formation of actin tails. PF03797.1;PF12951.1 0 autotranspoter "D3GTA3_ECO44 Autotransporter OS=Escherichia coli O44:H18 (strain 042 / EAEC)\nC8UIA6_ECO1A AidA-I adhesin-like protein OS=Escherichia coli O111:H- (strain 11128 / EHEC)\nB7L444_ECO55 Putative beta-barrel outer membrane protein,similar to AidA-I adhesin-like protein OS=Escherichia coli (strain 55989 / EAEC)\nB7L444_ECO55 Putative beta-barrel outer membrane protein,similar to AidA-I adhesin-like protein OS=Escherichia coli (strain 55989 / EAEC)" 3ML3 1 1 Shigella flexneri 2a IpgD NP_085296 21501826 Shigella flexneri 2a It disconnects the actin subcortical cytoskeleton from the membrane and favors actin dynamics at the entry site. PF05925.7 0 invasion protein "E1W7C2_SALTS Type III secretion system effector protein. Activates Cdc42, RhoG, AktA and chloride secretion through its inositol phosphatase activity and disrupt tight junctions OS=Salmonella typhimurium (strain SL1344)\n|F5ZP37_SALTU Secreted effector protein OS=Salmonella typhimurium (strain ATCC 68169 / UK-1)\nB5R028_SALEP Cell invasion protein OS=Salmonella enteritidis PT4 (strain P125109)\nC3NPR3_VIBCJ Putative uncharacterized protein OS=Vibrio cholerae serotype O1 (strain MJ-1236)\nA5F7C1_VIBC3 Restin-related protein OS=Vibrio cholerae serotype O1 (strain ATCC 39541 / Ogawa 395 / O395)" 3F6K 1 1 Shigella flexneri 2a set1A CAA87457 10523561 ;7769126 Shigella flexneri 2a It may account for the early diarrheal phase often observed during shigellosis. PF13831.1 0 toxin D3GV23_ECO44 Enterotoxin 1 OS=Escherichia coli O44:H18 (strain 042 / EAEC)\nQ5CYM9_CRYPI CpCCp1/Cpa135 OS=Cryptosporidium parvum (strain Iowa II)\nQ5CSL9_CRYPI Putative uncharacterized protein OS=Cryptosporidium parvum (strain Iowa II) 3UVN 1 1 Shigella flexneri 2a set1B CAA87456 10523561 ;7769126 Shigella flexneri 2a It may account for the early diarrheal phase often observed during shigellosis. CAA87456 0 toxin D3GV23_ECO44 Enterotoxin 1 OS=Escherichia coli O44:H18 (strain 042 / EAEC)\nQ5CQZ4_CRYPI Predicted coiled-coil protein OS=Cryptosporidium parvum (strain Iowa II)\nA3FQI5_CRYPI XPA binding protein 1 OS=Cryptosporidium parvum (strain Iowa II) 3UVO 0 1 Shigella flexneri 2a senB EIQ22554 15191388 Shigella flexneri 2a It may account for the early diarrheal phase often observed during shigellosis. PF08450.7 0 toxin E1WBR7_SALTS Possible ATP-binding protein OS=Salmonella typhimurium (strain SL1344)\nB5QTL6_SALEP Possible ATP-binding protein OS=Salmonella enteritidis PT4 (strain P125109)\nF5ZQQ6_SALTU Putative periplasmic protein OS=Salmonella typhimurium (strain ATCC 68169 / UK-1)\nB7L6G8_ECO55 Putative uncharacterized protein yncE OS=Escherichia coli (strain 55989 / EAEC) 0 1 Shigella flexneri 2a sat YP_005729388 11923399;15191388 Shigella flexneri 2a It takes part in serine-type endopeptidase activity. PF02395.11;PF04851.10 0 serine protease PET_ECO44 Serine protease pet autotransporter OS=Escherichia coli O44:H18 (strain 042 / EAEC)\nC8URD7_ECO1A Predicted serine protease EspP OS=Escherichia coli O111:H- (strain 11128 / EHEC)\nB5YPI9_ECO5E Immunoglobulin A1 protease domain protein OS=Escherichia coli O157:H7 (strain EC4115 / EHEC) 0 1 Shigella flexneri 2a SHI-2 (SelC) YP_002410066 10411725 Shigella flexneri 2a SHI-2 may allow Shigella survival in stressful environments such as those encountered during infection. PF13563.1;PF13432.1;PF12895.1;PF07719.1 0 iron acquisition system protein C8UMT5_ECO1A Conserved predicted protein OS=Escherichia coli O111:H- (strain 11128 / EHEC)\nC9YNJ8_CLODR Putative uncharacterized protein OS=Clostridium difficile (strain R20291)\nC9XL52_CLODC Putative uncharacterized protein OS=Clostridium difficile (strain CD196)\nQ185D3_CLOD6 Putative uncharacterized protein OS=Clostridium difficile (strain 630) 0 1 Shigella flexneri 2a SRL YP_690188 11553538 Shigella flexneri 2a It contains genes encoding resistance to streptomycin ampicillin and tetracycline and a complete ferric dicitrate uptake system. PF08220.1;PF00455.1 0 regulatory protein C8UEQ9_ECO1A DNA-binding transcriptional repressor SrlR OS=Escherichia coli O111:H- (strain 11128 / EHEC)\nB7LEB8_ECO55 DNA-bindng transcriptional repressor OS=Escherichia coli (strain 55989 / EAEC)\nD3GRN9_ECO44 Glucitol operon repressor OS=Escherichia coli O44:H18 (strain 042 / EAEC)\nB5Z368_ECO5E Glucitol operon repressor OS=Escherichia coli O157:H7 (strain EC4115 / EHEC) 0 1 Shigella flexneri 2a icsP NP_858404 9076742 Shigella flexneri 2a It is involved in the cleavage of IcsA may contribute to the polar distribution of IcsA on the lateral side of the bacterial surface. PF01278.15 0 outer membrane protease B7UKK8_ECO27 Putative outer membrane protease OmpT OS=Escherichia coli O127:H6 (strain E2348/69 / EPEC)\nC8UJM7_ECO1A Putative outer membrane protease OS=Escherichia coli O111:H- (strain 11128 / EHEC)\n|B5YXJ1_ECO5E Protease 7 OS=Escherichia coli O157:H7 (strain EC4115 / EHEC)\nC6URZ0_ECO5T Outer membrane protease VII (Outer membrane protein 3b) OS=Escherichia coli O157:H7 (strain TW14359/ EHEC 3UJ0 1 1 Shigella flexneri 2a iucA NP_709454 10411724;12384590 Shigella flexneri 2a It helps in iron uptake and critical for intracellular growth. PF04183.7;PF06276.7 0 iron acquisition system protein C8UMW1_ECO1A Siderophore biosynthesis protein OS=Escherichia coli O111:H- (strain 11128 / EHEC)\nB7LBV0_ECO55 Aerobactin siderophore biosynthesis protein OS=Escherichia coli (strain 55989 / EAEC)\nB7LBV0_ECO55 Aerobactin siderophore biosynthesis protein OS=Escherichia coli (strain 55989 / EAEC)\nQ87FL8_VIBPA Putative AcsD OS=Vibrio parahaemolyticus 0 1 Shigella flexneri 2a iucB NP_709455 10411724;12384590 Shigella flexneri 2a It helps in iron uptake and critical for intracellular growth. PF13523.1 0 iron acquisition system protein No Homolog Found 1 0 Shigella flexneri 2a iucC NP_709456 10411724;12384590 Shigella flexneri 2a It helps in iron uptake and critical for intracellular growth. PF04183.7;PF06276.7 0 iron acquisition system protein No Homolog Found 0 0 Shigella flexneri 2a iucD NP_709457 10411724;12384590 Shigella flexneri 2a It helps in iron uptake and critical for intracellular growth. PF13434.1 0 iron acquisition system protein No Homolog Found 0 0 Shigella flexneri 2a iutA NP_709458 10411724;12384590 Shigella flexneri 2a It helps in iron uptake and critical for intracellular growth. PF07715.10;PF00593.19 0 iron acquisition system protein B7LBU6_ECO55 Ferric aerobactin receptor OS=Escherichia coli (strain 55989 / EAEC)\nB7LBU6_ECO55 Ferric aerobactin receptor OS=Escherichia coli (strain 55989 / EAEC)\nC8UMW5_ECO1A Putative ferric siderophore receptor OS=Escherichia coli O111:H- (strain 11128 / EHEC)\nQ87HI4_VIBPA Ferric aerobactin receptor OS=Vibrio parahaemolyticus\nA8FNS5_CAMJ8 Haemin uptake system outer membrane receptor OS=Campylobacter jejuni subsp. jejuni serotype O:6 (strain 81116 / NCTC 11828)\nA1W1L6_CAMJJ TonB-dependent heme receptor OS=Campylobacter jejuni subsp. jejuni serotype O:23/36 (strain 81-176) 0 1 Shigella boydii SHI-3 Q93PE7 11418557 Shigella boydii SHI-3 is associated with a deletion of more than 6 kb relative to the E. coli K-12 sequence including cadA lysine decarboxylase. Cadaverine produced by the decarboxylation of lysine inhibits Shigella enterotoxic activity. So acquisition of SHI-3 is associated with enhancing the virulence of Shigella 0 transporter protein No Homolog Found 0 0 Shigella dysenteriae stxA YP_403025 11377211 Shigella dysenteriae It is a Shiga toxin producing protein which is an important factor in disease pathogenesis and is responsible for the haemolytic uremic syndrome (HUS). PF00161.14 0 toxin C8UEJ9_ECO1A Shiga toxin 1 subunit A OS=Escherichia coli O111:H- (strain 11128 / EHEC)\nB5YYR1_ECO5E Shiga toxin subunit A OS=Escherichia coli O157:H7 (strain EC4115 / EHEC)\nB5YYR1_ECO5E Shiga toxin subunit A OS=Escherichia coli O157:H7 (strain EC4115 / EHEC)\nB5YTI3_ECO5E Shiga toxin subunit A OS=Escherichia coli O157:H7 (strain EC4115 / EHEC) 0 1 Shigella dysenteriae stxB AAF28122 11377211 Shigella dysenteriae It is a Shiga toxin producing protein which is an important factor in disease pathogenesis and is responsible for the haemolytic uremic syndrome (HUS). PF02258.11 0 toxin C8UEK0_ECO1A Shiga toxin 1 subunit B OS=Escherichia coli O111:H- (strain 11128 / EHEC)\nB5YYR0_ECO5E Shiga toxin 2 B subunit OS=Escherichia coli O157:H7 (strain EC4115 / EHEC)\nC6UP08_ECO5T Shiga toxin II subunit B OS=Escherichia coli O157:H7 (strain TW14359 / EHEC)\nC8UC21_ECO1A Shiga toxin 2 subunit B OS=Escherichia coli O111:H- (strain 11128 / EHEC)\nC6UZN0_ECO5T Shiga-like toxin II subunit B OS=Escherichia coli O157:H7 (strain TW14359 / EHEC) 0 1 Yersinia enterocolitica YstA P07593.2 12620874 ;18557936 Yersinia enterocolitica It is structurally and functionally homologous to the heat-stable enterotoxin of ETEC and Important in causing Yersinia-associated diarrhea. PF02048.11 0 toxin No Homolog Found 1MKM 1 0 Yersinia enterocolitica YstB BAA13544 12620874 ;18557936 Yersinia enterocolitica It is structurally and functionally homologous to the heat-stable enterotoxin of ETEC and Important in causing Yersinia-associated diarrhea. PF02048.11 0 toxin Q87KQ9_VIBPA Putative uncharacterized protein VP2917 OS=Vibrio parahaemolyticus 0 1 Yersinia enterocolitica YstC O50319 18557936 Yersinia enterocolitica It is structurally and functionally homologous to the heat-stable enterotoxin of ETEC and Important in causing Yersinia-associated diarrhea. PF02048.11 0 toxin No Homolog Found 3MK4 1 0 Yersinia enterocolitica Inv Q5DQI5 18557936 Yersinia enterocolitica It promotes both attachment and invasion into eukaryotic cells including nonphagocytic cells. PF02371.1;PF01548 0 invasion protein "B7L511_ECO55 Transposase, IS110 family OS=Escherichia coli (strain 55989 / EAEC)\nB7L4Z1_ECO55 Transposase, IS110 family OS=Escherichia coli (strain 55989 / EAEC)\nB7LF78_ECO55 Transposase, IS110 family OS=Escherichia coli (strain 55989 / EAEC)" 0 1 Yersinia enterocolitica myfF Q56849 7836309 Yersinia enterocolitica The Yersinia enterocolitica surface antigen Myf is a fibrillar structure that resembles CS3 fimbriae and could be an element of the signal transducing system. PF00895.2 0 adhesin E1W934_SALTS Allantoate amidohydrolase OS=Salmonella typhimurium (strain SL1344)\nB5QUU0_SALEP Allantoate amidohydrolase OS=Salmonella enteritidis PT4 (strain P125109)\nF5ZMM9_SALTU Allantoate amidohydrolase OS=Salmonella typhimurium (strain ATCC 68169 / UK-1) 2DMH 1 1 Salmonella enterica ail A1JLR8 12620874 ;18557936 Salmonella enterica Promoting attachment to and subsequent invasion of eukaryotic cells but a less powerful adhesion than Inv. The receptor for Ail remains to be identified. PF13505 0 invasion protein A1JLR8_YERE8 Attachment invasion locus protein OS=Yersinia enterocolitica serotype O:8 / biotype 1B (strain 8081)\nOMPX_SHIFL Outer membrane protein X OS=Shigella flexneri\nQ0T6E7_SHIF8 Outer membrane protein X OS=Shigella flexneri serotype 5b (strain 8401)\nQ323X9_SHIBS Outer membrane protein X OS=Shigella boydii serotype 4 (strain Sb227) 0 1 Salmonella enterica yadA NP_863557 11107778;18557936;12620874 Salmonella enterica Bind a variety of eukaryotic extracellular and cell surface molecules including collagens fibronectin and laminins and can also mediate internalization. PF05658.9;PF05662.9;PF03895.10 0 adhesin YADA_YERE8 Adhesin yadA OS=Yersinia enterocolitica serotype O:8 / biotype 1B (strain 8081)\nC8UIZ2_ECO1A Putative adhesin OS=Escherichia coli O111:H- (strain 11128 / EHEC)\nB7L728_ECO55 Putative uncharacterized protein OS=Escherichia coli (strain 55989 / EAEC)\nB7L728_ECO55 Putative uncharacterized protein OS=Escherichia coli (strain 55989 / EAEC) 1P9H 1 1 Salmonella enterica virF NP_783684 11107778;18557936;12620874 Salmonella enterica It induces microtubule destablization provokes the formation of membrane ruffles promotes the bacteria entry into host cells. PF02311.14;PF12833.2;PF12833.2 0 regulatory protein VIRF_YERE8 Virulence regulon transcriptional activator virF OS=Yersinia enterocolitica serotype O:8 / biotype 1B (strain 8081)\nQ87P19_VIBPA Transcriptional regulator ExsA OS=Vibrio parahaemolyticus\nA1JIK6_YERE8 Putative AraC-family regulatory protein OS=Yersinia enterocolitica serotype O:8 / biotype 1B (strain 8081)\nA1JLW0_YERE8 Putative AraC-family transcriptional regulatory protein OS=Yersinia enterocolitica serotype O:8 / biotype 1B (strain 8081) 2XXN 1 1 Salmonella enterica SipA NP_461803 12065528;12496143 Salmonella enterica Actin-binding protein that interferes with host cell actin cytoskeleton. It stimulates actin polymerization and counteracts F-actin destabilizing proteins. Potentiates sipC activity; both are required for an efficient bacterial internalization PF09052.5 0 toxin IPAA_SHIFL Invasin ipaA OS=Shigella flexneri\nC8UH40_ECO1A 1-deoxy-D-xylulose 5-phosphate reductoisomerase OS=Escherichia coli O111:H- (strain 11128 / EHEC)\nD3GRB8_ECO44 1-deoxy-D-xylulose 5-phosphate reductoisomerase OS=Escherichia coli O44:H18 (strain 042/ EAEC) 1Q5Z 1 1 Salmonella enterica SopA NP_461011 12065528;12496143 Salmonella enterica Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protein is an E3 ubiquitin ligase that interferes with host's ubiquitination pathway. PF13599.1;PF13981.1;PF13979.1 0 toxin B5YWP7_ECO5E Putative uncharacterized protein OS=Escherichia coli O157:H7 (strain EC4115 / EHEC)\nC8UNQ1_ECO1A T3SS secreted effector EspX-homolog OS=Escherichia coli O111:H- (strain 11128 / EHEC)\nC6URC5_ECO5T Non-LEE-encoded type III secreted effector OS=Escherichia coli O157:H7 (strain TW14359 / EHEC)\nB5YS90_ECO5E Putative uncharacterized protein OS=Escherichia coli O157:H7 (strain EC4115 / EHEC) 2QYU 1 1 Salmonella enterica SopB NP_460064 12065528;12496143 Salmonella enterica It is one of the known effectors injected by Salmonella into the host cell and is required for invasion and for an efficient generation and maintenance of Salmonella-containing vacuole (SVC). PF05925.7;PF13350.1 0 toxin IPGD_SHIFL Inositol phosphate phosphatase ipgD OS=Shigella flexneri 3MKY 1 1 Salmonella enterica SopD NP_461866 12496143 Salmonella enterica Stimulates actin cytoskeleton reorganization nuclear responses and chloride secretion. PF11047.3;PF12864.2 0 toxin "ARTP_SHIFL Arginine transport ATP-binding protein ArtP OS=Shigella flexneri\nQ0T8Q4_SHIF8 ATP-binding component of 3rd arginine transport system OS=Shigella flexneri serotype 5b (strain 8401)\nB5YSF9_ECO5E Arginine ABC transporter, ATP-binding protein OS=Escherichia coli O157:H7 (strain EC4115 /EHEC)" 0 1 Salmonella enterica SopE2 NP_460811 12065528;12496143 Salmonella enterica Stimulates actin cytoskeleton rearrangements and nuclear responses and acts as Guanine nucleotide exchanges factor for Cdc42 and Rac. PF05364.9;PF07487.8 0 toxin A1JMP0_YERE8 Putative ROK family transcriptional regulatory protein OS=Yersinia enterocolitica serotype O:8 / biotype 1B (strain 8081)\nBIOF_SHIBS 8-amino-7-oxononanoate synthase OS=Shigella boydii serotype 4 (strain Sb227)\nBIOF_ECO5E 8-amino-7-oxononanoate synthase OS=Escherichia coli O157:H7 (strain EC4115 / EHEC)\nC6V2D5_ECO5T 8-amino-7-oxononanoate synthaseOS=Escherichia coli O157:H7 (strain TW14359 / EHEC) 1R9K 1 1 Salmonella enterica SopE NP_458691 15716426;10047557 Salmonella enterica Stimulates actin cytoskeleton rearrangements and nuclear responses and acts as Guanine nucleotide exchanges factor for Cdc42 and Rac. PF05364.9;PF07487.8 0 toxin C3NQP9_VIBCJ Chemotaxis protein CheA OS=Vibrio cholerae serotype O1 (strain MJ-1236)\nC3LM92_VIBCM Chemotaxis protein CheA OS=Vibrio cholerae serotype O1 (strain M66-2)\n5F8D5_VIBC3 Chemotaxis protein CheA OS=Vibrio cholerae serotype O1 (strain ATCC 39541 / Ogawa 395 / O395) 1GZ2 1 1 Salmonella enterica SspH1 AAD40326 10047557 Salmonella enterica SspH1 is a member of the bacterial LPX repeat protein family that localizes to the mammalian nucleus and inhibits NF-?B-dependent gene expression. PF06767.6;PF12468.3;PF12799.2;PF13855.1 0 toxin No Homolog Found 0 0 Salmonella enterica SipC NP_461805 12532221 Salmonella enterica Required for TTSS effector protein translocation through eukaryotic cell membranes. PF09599.5;PF14160.1 0 toxin IPAC_SHIFL Invasin ipaC OS=Shigella flexneri\nB7L6W3_ECO55 Putative uncharacterized protein yhjY OS=Escherichia coli (strain 55989 / EAEC)\nQ83PR7_SHIFL Putative lipase OS=Shigella flexneri 0 1 Salmonella enterica AvrA NP_461786 10047557 Salmonella enterica Sequence homology to YopJ which has been proposed to be an ubiquitin-like protein proteinase and induces apoptosis of macrophages. PF03421.11 0 toxin A1JUC5_YERE8 Type III secretion system effector protein (Putative targeted effector protein) OS=Yersinia enterocolitica serotype O:8 / biotype 1B (strain 8081)\nQ87GH0_VIBPA Putative targeted effector protein YopP OS=Vibrio parahaemolyticus 0 1 Salmonella enterica SptP NP_461799 10047557 Salmonella enterica It alters host cell physiology and promote bacterial survival in host tissues. This protein is an E3 ubiquitin ligase that interferes with host's ubiquitination pathway. Can ubiquitinate both ubiquitin and host PKN1. Down-modulates production of host proinflammatory cytokines by inhibiting NF-kappa-B-dependent gene expression probably via interaction with PKN1. PF09119.5;PF03545.8;F00102.22 0 toxin A1JTB0_YERE8 Possible tyrosine phosphatase OS=Yersinia enterocolitica serotype O:8 / biotype 1B (strain 8081)\nA1JUA6_YERE8 Putative uncharacterized protein OS=Yersinia enterocolitica serotype O:8 / biotype 1B (strain 8081)\nA0KFJ7_AERHH Protein tyrosine phosphatase OS=Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / NCIB 9240) 1G4W 1 1 Salmonella enterica SipD AAA86617 10047557;21829362 Salmonella enterica Necessary for the translocation of other factors into host cells. PF06511.6 0 toxin IPAD_SHIFL Invasin ipaD OS=Shigella flexneri\nD3H2F6_ECO44 Putative cell invasion type III effector protein OS=Escherichia coli O44:H18 (strain 042 / EAEC) 2YM9 1 1 Salmonella enterica Trk AAL22830 19001074 Salmonella enterica Part of the constitutive potassium transport systems trkG and trkH. May regulate the transport activity of trkG and trkH systems. Binds to NAD+ and NADH. In Salmonella it is required for resistance to antimicrobial peptides. PF02386.11 0 transporter protein TRKH_SHIFL Trk system potassium uptake protein trkH OS=Shigella flexneri\nQ31UE0_SHIBS TrkH OS=Shigella boydii serotype 4 (strain Sb227)\nB5YYY6_ECO5E Trk system potassium uptake protein TrkH OS=Escherichia coli O157:H7 (strain EC4115 / EHEC) 0 1 Salmonella enterica SseL YP_005243246 17158898 Salmonella enterica This protease targets the host cell ubiquitin pathway by acting as a deubiquitinase in infected host cells. PB002991 1 serine protease D3H1D7_ECO44 Putative peptidase OS=Escherichia coli O44:H18 (strain 042 / EAEC)\nC8UDM4_ECO1A Predicted enzyme OS=Escherichia coli O111:H- (strain 11128 / EHEC)\nC6UNQ3_ECO5T Predicted enzyme OS=Escherichia coli O157:H7 (strain TW14359 / EHEC) 0 1 Salmonella enterica spv AAL23532 9125562 Salmonella enterica It promotes the survival and rapid growth of Salmonella in the host. PF00126.22;PF06926.6 0 toxin Q0T0X9_SHIF8 Putative LYSR-type transcriptional regulator OS=Shigella flexneri serotype 5b (strain 8401)\nQ31WH9_SHIBS Putative transcriptional regulator LYSR-type OS=Shigella boydii serotype 4 (strain Sb227)\nC8UFC5_ECO1A Predicted DNA-binding transcriptional regulator OS=Escherichia coli O111:H- (strain 11128 / EHEC) 0 1 Salmonella enterica QseC NP_806783 20028809 Salmonella enterica Member of a two-component regulatory system qseB/qseC. Activates the flagella regulon by activating transcription of flhDC. May activate qseB by phosphorylation. PF07495.8;PF00672.20;PF00512.20;PF02518.21 0 sensor protein C8UFV9_ECO1A Sensory histidine kinase QseC in two-component regulatory system with QseB OS=Escherichia coli O111:H- (strain 11128 / EHEC)\nB7LGG9_ECO55 Sensory histidine kinase in two-component regulatory system with QseB OS=Escherichia coli (strain 55989 / EAEC) 3JZ3 1 1 Salmonella enterica csgA NP_460115 10760159;8550497;12949092 Salmonella enterica It is a fimbrial protein and aids in attachment to the villi of enterocytes and also cause the bacteria to become attached to each other PF07012.7;PF07012.7 0 adhesin Q31Z96_SHIBS CsgA OS=Shigella boydii serotype 4 (strain Sb227)\nC8UMY7_ECO1A Curlin major subunit CsgA OS=Escherichia coli O111:H- (strain 11128 / EHEC)\nB7LFF2_ECO55 Cryptic curlin major subunit OS=Escherichia coli (strain 55989 / EAEC) 0 1 Salmonella enterica csgB NP_460114 10760159;8550497;12949092 Salmonella enterica It is a fimbrial protein and aids in attachment to the villi of enterocytes and also cause the bacteria to become attached to each other PF07012.7 0 adhesin "Q83RU7_SHIFL Minor curlin subunit OS=Shigella flexneri\nC6UQK9_ECO5T Curlin nucleator protein, minor subunit in curli complex OS=Escherichia coli O157:H7 (strain TW14359 / EHEC)\nB7UP56_ECO27 Curlin nucleator protein, minor subunit in curli complex OS=Escherichia coli O127:H6 (strain E2348/69 / EPEC)" 0 1 Salmonella enterica csgC NP_460116 8550497 Salmonella enterica It is a fimbrial protein and aids in attachment to the villi of enterocytes and also cause the bacteria to become attached to each other PF10610.4 0 adhesin "C8UMY8_ECO1A Predicted curli production protein OS=Escherichia coli O111:H- (strain 11128 / EHEC)\nB7LFF3_ECO55 Putative curli production protein OS=Escherichia coli (strain 55989 / EAEC)\nB7LFF3_ECO55 Putative curli production protein OS=Escherichia coli (strain 55989 / EAEC) " 0 1 Salmonella enterica csgE NP_460112 12949092 Salmonella enterica It is a fimbrial protein and aids in attachment to the villi of enterocytes and also cause the bacteria to become attached to each other PF10627.4 0 adhesin B5YVR0_ECO5E Curli production assembly/transport subunit CsgE OS=Escherichia coli O157:H7 (strain EC4115 / EHEC)\nC6UQK6_ECO5T Predicted transport protein OS=Escherichia coli O157:H7 (strain TW14359 / EHEC)\nB7UP53_ECO27 Predicted transport protein OS=Escherichia coli O127:H6 (strain E2348/69 / EPEC) 0 1 Salmonella enterica csgF NP_460111 12949092;10760159 Salmonella enterica It is a fimbrial protein and aids in attachment to the villi of enterocytes and also cause the bacteria to become attached to each other PF10614.4 0 adhesin Q0T603_SHIF8 Curli production assembly/transport component csgF OS=Shigella flexneri serotype 5b (strain 8401)\nB5YVQ9_ECO5E Curli production assembly/transport component CsgF OS=Escherichia coli O157:H7 (strain EC4115 / EHEC)\nC6UQK5_ECO5T Predicted transport protein OS=Escherichia coli O157:H7 (strain TW14359 / EHEC) 0 1 Salmonella enterica csgG NP_460110 12949092 Salmonella enterica It is a fimbrial protein and aids in attachment to the villi of enterocytes and also cause the bacteria to become attached to each other PF03783.9 0 adhesin B7UP51_ECO27 Outer membrane lipoprotein OS=Escherichia coli O127:H6 (strain E2348/69 / EPEC)\nC8UMY1_ECO1A Outer membrane lipoprotein CsgG OS=Escherichia coli O111:H- (strain 11128 / EHEC)\nD3H140_ECO44 Curli production assembly/transport component OS=Escherichia coli O44:H18 (strain 042 /EAEC) 0 1 Salmonella enterica IpfA NP_462541 10557331;8552622 Salmonella enterica It is a chaperone molecule which mediates attachment to the Peyers patches. PF00419.15;PF07833.6 0 adhesin C6UXH4_ECO5T Putative major fimbrial subunit OS=Escherichia coli O157:H7 (strain TW14359 / EHEC)\nB7ULA9_ECO27 Predicted fimbrial major protein OS=Escherichia coli O127:H6 (strain E2348/69 / EPEC) 0 1 Salmonella enterica IpfB NP_462540 10557331;8552622 Salmonella enterica It is a chaperone molecule which mediates attachment to the Peyers patches. PF00345.15;PF02753.12 0 adhesin B5YVJ8_ECO5E Chaperone protein FimC OS=Escherichia coli O157:H7 (strain EC4115 / EHEC)\nC6UXH3_ECO5T Putative fimbrial chaperone OS=Escherichia coli O157:H7 (strain TW14359 / EHEC)\nC8UI31_ECO1A Putative fimbrial chaperone protein OS=Escherichia coli O111:H- (strain 11128 / EHEC) 0 1 Salmonella enterica IpfC NP_462539 10557331;8552622 Salmonella enterica It is a chaperone molecule which mediates attachment to the Peyers patches. PF13954.1;PF00577.15;PF13953.1 0 adhesin C8UI30_ECO1A Putative fimbrial usher protein OS=Escherichia coli O111:H- (strain 11128 / EHEC)\nB7L6W0_ECO55 Outer membrane usher protein lpfC OS=Escherichia coli (strain 55989 / EAEC)\nB7L6W0_ECO55 Outer membrane usher protein lpfCOS=Escherichia coli (strain 55989 / EAEC) 0 1 Salmonella enterica IpfD NP_462538 10557331;8552622 Salmonella enterica It is a chaperone molecule which mediates attachment to the Peyers patches. PF00419.15 0 adhesin C8UI29_ECO1A Putative minor fimbrial subunit OS=Escherichia coli O111:H- (strain 11128 / EHEC)\nB7L6V7_ECO55 LpfD protein OS=Escherichia coli (strain 55989 / EAEC)\nB7L6V7_ECO55 LpfD protein OS=Escherichia coli (strain 55989 / EAEC)\nB5YVJ7_ECO5E Protein LpfD OS=Escherichia coli O157:H7 (strain EC4115 / EHEC) 0 1 Salmonella enterica IpfE NP_462537 10557331;8552622 Salmonella enterica It is a chaperone molecule which mediates attachment to the Peyers patches. PF00419.15 0 adhesin C8UI28_ECO1A Putative fimbrial adhesin protein OS=Escherichia coli O111:H- (strain 11128 / EHEC)\nB7L6V8_ECO55 LpfE protein OS=Escherichia coli (strain55989 / EAEC)\nQ31V80_SHIBS Putative major fimbrial subunit OS=Shigella boydii serotype 4 (strain Sb227) 0 1 Salmonella enterica MisL NP_462656 15948960 Salmonella enterica MisL is an extracellular matrix adhesin (autotransporter protein) involved in intestinal colonization. PF03797.14 0 adhesin B5Z1R4_ECO5E Putative outer membrane autotransport OS=Escherichia coli O157:H7 (strain EC4115 / EHEC)\nC6UY30_ECO5T Putative beta-barrel outer membrane protein OS=Escherichia coli O157:H7 (strain TW14359 / EHEC) 0 1 Salmonella enterica pefA NP_490510 12533475;8557375 Salmonella enterica It mediates binding of the bacteria to the microvilli of enterocytes by adherence. PF00419.15;PF08798.6 0 adhesin Q83PK0_SHIFL Putative major fimbrial subunit OS=Shigella flexneri\nQ0SYS8_SHIF8 Putative major fimbrial subunit OS=Shigella flexneri serotype 5b (strain 8401)\nC8UJB8_ECO1A Putative fimbrial major protein OS=Escherichia coli O111:H- (strain 11128 / EHEC) 3L9V 1 1 Salmonella enterica pefb NP_490511 8557375 Salmonella enterica It mediates binding of the bacteria to the microvilli of enterocytes by adherence. PF03333.8 0 adhesin Q87HD2_VIBPA Putative uncharacterized protein VPA1033 OS=Vibrio parahaemolyticus\nA5F128_VIBC3 Putative uncharacterized protein OS=Vibrio cholerae serotype O1 (strain ATCC 39541 / Ogawa 395 / O395)\nA1JRV6_YERE8 Maltose transport system permease protein MalG OS=Yersinia enterocolitica serotype O:8 / biotype 1B (strain 8081) 3L9V 1 1 Salmonella enterica pefc NP_490509 8557375 Salmonella enterica It mediates binding of the bacteria to the microvilli of enterocytes by adherence. PF13954.1;PF00577.15;PF02321.13 0 adhesin B7LH82_ECO55 Putative outer membrane protein OS=Escherichia coli (strain 55989 / EAEC)\nB7LH82_ECO55 Putative outer membrane protein OS=Escherichia coli (strain 55989 / EAEC)\nC8UGA3_ECO1A Predicted outer membrane protein OS=Escherichia coli O111:H- (strain 11128 / EHEC) 3L9V 1 1 Salmonella enterica pefD NP_490508 8557375 Salmonella enterica It mediates binding of the bacteria to the microvilli of enterocytes by adherence. PF00345.15;PF02753.12 0 adhesin B5YZH7_ECO5E Pili assembly chaperone OS=Escherichia coli O157:H7 (strain EC4115 / EHEC)\nC6UWP5_ECO5T Fimbrial chaperone protein OS=Escherichia coli O157:H7 (strain TW14359 / EHEC)\nD3GR87_ECO44 Fimbrial chaperone protein OS=Escherichia coli O44:H18 (strain 042 / EAEC) 3L9V 1 1 Salmonella enterica ratB NP_461449 12540539 Salmonella enterica It is involved in intestinal colonization and persistence. PF05688.6;PF02369.11; 0 adhesin D3H303_ECO44 Putative outer membrane protein OS=Escherichia coli O44:H18 (strain 042 / EAEC)\nB7UGU8_ECO27 RatA-like protein OS=Escherichia coli O127:H6 (strain E2348/69 / EPEC)\nA1VXH6_CAMJJ Putative uncharacterized protein OS=Campylobacter jejuni subsp. jejuni serotype O:23/36 (strain 81-176) 0 1 Salmonella enterica shdA NP_461448 12540539 Salmonella enterica A large outer membrane protein of the autotransporter family whose passenger domain binds the extracellular matrix proteins fibronectin and collagen I possibly by mimicking the host ligand heparin PF12951.2;PF03797.14 0 adhesin B7UGL7_ECO27 AidA autotransporter-like protein OS=Escherichia coli O127:H6 (strain E2348/69 / EPEC)\nD3GTA3_ECO44 Autotransporter OS=Escherichia coli O44:H18 (strain 042 / EAEC)\nC8UIA6_ECO1A AidA-I adhesin-like protein OS=Escherichia coli O111:H- (strain 11128 / EHEC) 0 1 Salmonella enterica sinH NP_461452 12540539 Salmonella enterica It is involved in intestinal colonization and persistence. PF11924.3 0 adhesin D3H305_ECO44 Putative outer membrane protein OS=Escherichia coli O44:H18 (strain 042 / EAEC)\nB7UGV0_ECO27 Intimin-like protein OS=Escherichia coli O127:H6 (strain E2348/69 / EPEC) 0 1 Salmonella enterica fimA NP_459538 14573666;8288102 Salmonella enterica The adhesin Fim mediates T3SS1-independent uptake in murine DCs PF00419.15;PF05034.8 0 adhesin Q83SC7_SHIFL Putative fimbrial-like protein OS=Shigella flexneri\nB5YPP5_ECO5E Type-1 fimbrial protein homolog OS=Escherichia coli O157:H7 (strain EC4115 / EHEC)\nC6V066_ECO5T Predicted fimbrial-like adhesin protein OS=Escherichia coli O157:H7 (strain TW14359 / EHEC) 3QDH 1 1 Salmonella enterica fimC NP_459540 7935059 Salmonella enterica The adhesin Fim mediates T3SS1-independent uptake in murine DCs PF00345.15;PF02753.12 0 adhesin "B5YPP6_ECO5E Chaperone protein FimC homolog OS=Escherichia coli O157:H7 (strain EC4115 / EHEC)\nC6V067_ECO5T Pilin chaperone, periplasmic OS=Escherichia coli O157:H7 (strain TW14359 / EHEC)" 1BF8 1 1 Salmonella enterica fimD NP_459541 7935059 Salmonella enterica The adhesin Fim mediates T3SS1-independent uptake in murine DCs PF13954.1;PF00577.15;PF13953.1 0 adhesin B7L8D7_ECO55 Putative outer membrane export usher protein OS=Escherichia coli (strain 55989 / EAEC)\nB7L8D7_ECO55 Putative outer membrane export usher protein OS=Escherichia coli (strain 55989 / EAEC)\nD3GW80_ECO44 Fimbrial outer membrane usher protein OS=Escherichia coli O44:H18 (strain 042 / EAEC) 3OHN 1 1 Salmonella enterica fimF NP_459543 9537754 Salmonella enterica The adhesin Fim mediates T3SS1-independent uptake in murine DCs PF00419.15 0 adhesin D3GW82_ECO44 Fimbrial protein OS=Escherichia coli O44:H18 (strain 042 / EAEC)\nC8UJK8_ECO1A Predicted fimbrial-like adhesin protein SfmFOS=Escherichia coli O111:H- (strain 11128 / EHEC)\nC6V070_ECO5T Predicted fimbrial-like adhesin protein OS=Escherichia coli O157:H7 (strain TW14359 / EHEC) 2JMR 1 1 Salmonella enterica fimH NP_459542 9537754;10026202;17379714 Salmonella enterica The adhesin Fim mediates T3SS1-independent uptake in murine DCs PF00419.15 0 adhesin D3GW81_ECO44 Fimbrial protein OS=Escherichia coli O44:H18 (strain 042 / EAEC)\nB5YPP8_ECO5E Mannose binding protein FimH homolog OS=Escherichia coli O157:H7 (strain EC4115 / EHEC)\nC6V069_ECO5T Predicted fimbrial-like adhesin protein OS=Escherichia coli O157:H7 (strain TW14359 / EHEC) 4AUU 1 1 Salmonella enterica fimI NP_459539 7935059 Salmonella enterica The adhesin Fim mediates T3SS1-independent uptake in murine DCs PF00419.15 0 adhesin Q83P69_SHIFL Fimbrial protein OS=Shigella flexneri\nC6UPA0_ECO5T Fimbrial protein involved in type 1 pilus biosynthesis OS=Escherichia coli O157:H7 (strain TW14359 / EHEC)\nB5Z3Q3_ECO5E Type-1 fimbrial protein homolog OS=Escherichia coli O157:H7 (strain EC4115 / EHEC) 3CUF 1 1 Salmonella enterica fimW NP_459547 11359580;11133935 Salmonella enterica The adhesin Fim mediates T3SS1-independent uptake in murine DCs PF00196.14 0 adhesin A1JPL1_YERE8 Putative LuxR-family regulatory proteins OS=Yersinia enterocolitica serotype O:8 / biotype 1B (strain 8081)\nA1JTP7_YERE8 Putative luxR-family regulatory protein OS=Yersinia enterocolitica serotype O:8 / biotype 1B (strain 8081)\nA0KQV2_AERHH WavL OS=Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / NCIB 9240) 0 1 Salmonella enterica fimY NP_459545 11359580;11133935 Salmonella enterica The adhesin Fim mediates T3SS1-independent uptake in murine DCs PF00196.14 0 adhesin "B7UGL3_ECO27 Predicted protein OS=Escherichia coli O127:H6 (strain E2348/69 / EPEC)\nC3NNU3_VIBCJ Zinc ABC transporter ATP-binding protein ZnuC OS=Vibrio cholerae serotype O1 (strain MJ-1236)\nC3LP32_VIBCM Zinc ABC transporter, ATP-binding protein OS=Vibrio cholerae serotype O1 (strain M66-2) " 0 1 Salmonella enterica fimZ NP_459544 11359580;11133935 Salmonella enterica The adhesin Fim mediates T3SS1-independent uptake in murine DCs PF00196.14 0 adhesin B5YPQ0_ECO5E Fimbriae Z protein OS=Escherichia coli O157:H7 (strain EC4115 / EHEC)\nC6V071_ECO5T Predicted DNA-binding transcriptional regulator OS=Escherichia coli O157:H7 (strain TW14359 /EHEC)\nC8UJK9_ECO1A Predicted DNA-binding transcriptional regulator FimZ OS=Escherichia coli O111:H- (strain 11128 / EHEC) 0 1 Cryptosporidium parvum TRAP C1 XP_628162  10488169 Cryptosporidium parvum It plays a crucial role in C. parvum invasion of host enterocytes and elicit protective immune responses. PF00090.1 0 adhesin No Homolog Found 0 0 10488169 Cryptosporidium parvum COWP AAM43956 10488169 Cryptosporidium parvum The Cryptosporidium oocyst wall protein is a member of a multigene family and has a homolog in Toxoplasma and plays a role in the oocyst wall structure. PF01683.13;PF12662.2 0 adhesin No Homolog Found 0 0 Vibrio cholerae VopN Q6QVR4 21151774 Vibrio cholerae VopN localizes to stress fiber in host cells. PF07201.1 0 toxin A1JU81_YERE8 Type III secretion outer membrane protein OS=Yersinia enterocolitica serotype O:8 / biotype 1B (strain 8081)\nA1JMG9_YERE8 Formate acetyltransferase 1 OS=Yersinia enterocolitica serotype O:8 / biotype 1B (strain 8081)\nA0KJM1_AERHH Formate acetyltransferase OS=Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / NCIB 9240)\nB7UJ18_ECO27 Pyruvate formate-lyase 4/2-ketobutyrate formate-lyase OS=Escherichia coli O127:H6 (strain E2348/69 / EPEC) 0 1 Vibrio cholerae VopE 3GS6_A 21151774 Vibrio cholerae Within the T3SS pathogenicity island is VopE a homolog of YopE from Yersinia which has been shown to loosen tight junctions. PF00933.2 0 toxin No Homolog Found 0 0 Vibrio cholerae VopF ACF94685 21151774 Vibrio cholerae It is required for colonization in Vibrio cholerae. PF06346.7;PF02205.15 0 toxin A1JU81_YERE8 Type III secretion outer membrane protein OS=Yersinia enterocolitica serotype O:8 / biotype 1B (strain 8081) 0 1 Vibrio cholerae AcfA NP_230492 7737517;10952301;11179381 Vibrio cholerae It plays a role in chemotaxis thereby assisting in intestinal colonization PF13505.1;PF13738.1 0 adhesin A1JMT3_YERE8 Putative outer membrane porin A protein OS=Yersinia enterocolitica serotype O:8 / biotype 1B (strain 8081)\nA8FNR2_CAMJ8 Imidazole glycerol phosphate synthase subunit HisH 2 OS=Campylobacter jejuni subsp. jejuni serotype O:6 (strain 81116 / NCTC 11828)\nD3GX68_ECO44 Putative uncharacterized protein OS=Escherichia coli O44:H18 (strain 042 / EAEC)\nQ324U2_SHIBS Putative uncharacterized protein ybdN OS=Shigella boydii serotype 4 (strain Sb227) 0 1 Vibrio cholerae AcfB NP_230488 8039900;10952301 Vibrio cholerae It plays a role in chemotaxis thereby assisting in intestinal colonization PF05581.7;PF02203.10;PF02743.13;PF00672.20 ;PF07926.7;PF06008.9;PF11053.3;PF00015.16;PF06008.9 0 adhesin A0KNK5_AERHH Methyl-accepting chemotaxis protein OS=Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / NCIB 9240)\nA0KN47_AERHH Methyl-accepting chemotaxis protein OS=Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / NCIB 9240)\nA0KHD6_AERHH Methyl-accepting chemotaxis protein OS=Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / NCIB 9240) 0 1 Vibrio cholerae AcfC NP_230489 7894059; 8039900;1644747 Vibrio cholerae It plays a role in chemotaxis thereby assisting in intestinal colonization PF13531.1 0 adhesin B5YYH6_ECO5E Porcine attaching-effacing associated protein OS=Escherichia coli O157:H7 (strain EC4115 / EHEC)\nC6USL4_ECO5T Colonization factor OS=Escherichia coli O157:H7 (strain TW14359 / EHEC)\nC8UQ02_ECO1A Porcine attaching-effacing associated protein Paa/adherence factor AdfO OS=Escherichia coli O111:H- (strain 11128 / EHEC) 0 1 Vibrio cholerae AcfD NP_230493 1644747;10952301 Vibrio cholerae It plays a role in chemotaxis thereby assisting in intestinal colonization PF13322.1;PF13402.1 0 adhesin C8UFQ7_ECO1A Putative lipoprotein AcfD homolog OS=Escherichia coli O111:H- (strain 11128 / EHEC)\nB7LGB2_ECO55 Inner membrane lipoprotein OS=Escherichia coli (strain 55989 / EAEC)\nB7LGB2_ECO55 Inner membrane lipoprotein OS=Escherichia coli (strain 55989 / EAEC)\nB7UI41_ECO27 Predicted inner membrane lipoprotein OS=Escherichia coli O127:H6 (strain E2348/69 / EPEC) 0 1 Vibrio cholerae tcpA NP_230476 8698524;7565104;7854116;8621096;8097178 Vibrio cholerae Crucial for V.cholerae to establish colonization in vivo and expressed before CT and acts as the receptor for entry of CTX? (the filamentous phage encoding the cholera toxin genes) into the cell is the TCP PF13544.1;PF04530.7;PF07044.6;PF05946.7 0 toxin D3GUV7_ECO44 Type II secretion system protein H OS=Escherichia coli O44:H18 (strain 042 / EAEC)\nB7LGA4_ECO55 Putative uncharacterized protein OS=Escherichia coli (strain 55989 / EAEC)\nB7LGA4_ECO55 Putative uncharacterized protein OS=Escherichia coli (strain 55989 / EAEC)\nA0KG53_AERHH Putative type IV pilin OS=Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / NCIB 9240) 3HRV 1 1 Vibrio cholerae tcpB NP_230477 8621096 Vibrio cholerae Crucial for V.cholerae to establish colonization in vivo and expressed before CT and acts as the receptor for entry of CTX? (the filamentous phage encoding the cholera toxin genes) into the cell is the TCP PF07301.6 0 toxin C9YIH5_CLODR Subunit of oxygen-sensitive 2-hydroxyisocaproyl-CoA dehydratase OS=Clostridium difficile (strain R20291)\nC9XK85_CLODC Subunit of oxygen-sensitive 2-hydroxyisocaproyl-CoA dehydratase OS=Clostridium difficile (strain CD196)\nQ188I6_CLOD6 Subunit of oxygen-sensitive 2-hydroxyisocaproyl-CoA dehydratase C OS=Clostridium difficile (strain 630) 0 1 Vibrio cholerae tcpC NP_230479 15774863 Vibrio cholerae Crucial for V.cholerae to establish colonization in vivo and expressed before CT and acts as the receptor for entry of CTX? (the filamentous phage encoding the cholera toxin genes) into the cell is the TCP PF00263.16 0 toxin BFPB_ECO27 Outer membrane lipoprotein BfpB OS=Escherichia coli O127:H6 (strain E2348/69 / EPEC) 0 1 Vibrio cholerae tcpD NP_230481 8097178 Vibrio cholerae Crucial for V.cholerae to establish colonization in vivo and expressed before CT and acts as the receptor for entry of CTX? (the filamentous phage encoding the cholera toxin genes) into the cell is the TCP PF14283.1;PF09976.4 0 toxin A3FPS2_CRYPI ATP synthase subunit alpha OS=Cryptosporidium parvum (strain Iowa II) 0 1 Vibrio cholerae tcpE NP_230484 8097177;8097178 Vibrio cholerae Crucial for V.cholerae to establish colonization in vivo and expressed before CT and acts as the receptor for entry of CTX? (the filamentous phage encoding the cholera toxin genes) into the cell is the TCP PF00482.18;PF00482.18 0 toxin B7UTD7_ECO27 Transmembrane protein OS=Escherichia coli O127:H6 (strain E2348/69 / EPEC)\nA1JQ41_YERE8 Type IV pilus integral membrane protein OS=Yersinia enterocolitica serotype O:8 / biotype 1B (strain 8081)\nA1JPH2_YERE8 General secretion pathway protein OS=Yersinia enterocolitica serotype O:8 / biotype 1B (strain 8081) 0 1 Vibrio cholerae tcpF NP_230485 8097177;1400247;8097178 Vibrio cholerae Crucial for V.cholerae to establish colonization in vivo and expressed before CT and acts as the receptor for entry of CTX? (the filamentous phage encoding the cholera toxin genes) into the cell is the TCP PF06340.6 0 toxin No Homolog Found 0 0 Vibrio cholerae tcpH NP_230475 8621096;10048021 Vibrio cholerae Crucial for V.cholerae to establish colonization in vivo and expressed before CT and acts as the receptor for entry of CTX? (the filamentous phage encoding the cholera toxin genes) into the cell is the TCP 0 toxin YAET_SHIFL Outer membrane protein assembly factor YaeT OS=Shigella flexneri\nYAET_SHIF8 Outer membrane protein assembly factor YaeT OS=Shigella flexneri serotype 5b (strain 8401)\nYAET_SHIBS Outer membrane protein assembly factor YaeT OS=Shigella boydii serotype 4 (strain Sb227)\nYAET_ECO5E Outer membrane protein assembly factor YaeT OS=Escherichia coli O157:H7 (strain EC4115 / EHEC)\nC6UWT0_ECO5T Outer membrane protein assembly factor YaeT OS=Escherichia coli O157:H7 (strain TW14359 / EHEC) 0 1 Vibrio cholerae tcpI NP_230473 8005659;8621096 Vibrio cholerae Crucial for V.cholerae to establish colonization in vivo and expressed before CT and acts as the receptor for entry of CTX? (the filamentous phage encoding the cholera toxin genes) into the cell is the TCP PF14126.1;PF02743.13;PF00672.20;PF00015.16 0 toxin A0KN47_AERHH Methyl-accepting chemotaxis protein OS=Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / NCIB 9240)\nA0KIN7_AERHH Methyl-accepting chemotaxis protein OS=Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / NCIB 9240)\nA0KIA7_AERHH Methyl-accepting chemotaxis protein OS=Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / NCIB 9240) 0 1 Vibrio cholerae tcpJ NP_230487 8097178 Vibrio cholerae Crucial for V.cholerae to establish colonization in vivo and expressed before CT and acts as the receptor for entry of CTX? (the filamentous phage encoding the cholera toxin genes) into the cell is the TCP PF06750.8;PF12773.2;PF10217.4;PF01478.13 0 toxin A1JQ48_YERE8 Putative type IV pilus operon lipoprotein OS=Yersinia enterocolitica serotype O:8 / biotype 1B (strain 8081)\nC9XMK7_CLODC Uracil-DNA glycosylase OS=Clostridium difficile (strain CD196)\nUNG_CLOD6 Uracil-DNA glycosylase OS=Clostridium difficile (strain 630) 0 1 Vibrio cholerae tcpP NP_230474 10198025;7565104;8621096;10048021 Vibrio cholerae Crucial for V.cholerae to establish colonization in vivo and expressed before CT and acts as the receptor for entry of CTX? (the filamentous phage encoding the cholera toxin genes) into the cell is the TCP PF00486.23 0 toxin "A1JPG4_YERE8 Possible reguatory protein OS=Yersinia enterocolitica serotype O:8 / biotype 1B (strain 8081)\nD3H2F7_ECO44 Transcriptional regulator OS=Escherichia coli O44:H18 (strain 042 / EAEC)\nA0KH61_AERHH Transcriptional regulator OS=Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / NCIB 9240)\nQ5CTP3_CRYPI Proteasome regulatory subunit Rpn7/26S proteasome subunit 6, PINT domain containing protein OS=Cryptosporidium parvum (strain Iowa II) " 0 1 Vibrio cholerae tcpQ NP_230478 8621096 Vibrio cholerae Crucial for V.cholerae to establish colonization in vivo and expressed before CT and acts as the receptor for entry of CTX (the filamentous phage encoding the cholera toxin genes) into the cell is the TCP PF10671.4 0 toxin A1JQ48_YERE8 Putative type IV pilus operon lipoprotein OS=Yersinia enterocolitica serotype O:8 / biotype 1B (strain 8081)\nC9XMK7_CLODC Uracil-DNA glycosylase OS=Clostridium difficile (strain CD196)\nUNG_CLOD6 Uracil-DNA glycosylase OS=Clostridium difficile (strain 630) 0 1 Vibrio cholerae tcpR NP_230480 8097178 Vibrio cholerae Crucial for V.cholerae to establish colonization in vivo and expressed before CT and acts as the receptor for entry of CTX(the filamentous phage encoding the cholera toxin genes) into the cell is the TCP No pfam domain found 0 toxin A1JQ48_YERE8 Putative type IV pilus operon lipoprotein OS=Yersinia enterocolitica serotype O:8 / biotype 1B (strain 8081)\nC9XMK7_CLODC Uracil-DNA glycosylase OS=Clostridium difficile (strain CD196)\nUNG_CLOD6 Uracil-DNA glycosylase OS=Clostridium difficile (strain 630) 0 1 Vibrio cholerae tcpS NP_230482 8097178 Vibrio cholerae Crucial for V.cholerae to establish colonization in vivo and expressed before CT and acts as the receptor for entry of CTX(the filamentous phage encoding the cholera toxin genes) into the cell is the TCP PF12097.3;PF13334.1;PF05852.6;PF13234.1;PF11429.3 0 toxin A0KHZ7_AERHH Structural toxin protein RtxA OS=Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / NCIB 9240) 0 1 Vibrio cholerae tcpT NP_230483 8097178 Vibrio cholerae Crucial for V.cholerae to establish colonization in vivo and expressed before CT and acts as the receptor for entry of CTX (the filamentous phage encoding the cholera toxin genes) into the cell is the TCP PF02876.12;PF00437.15;PF04640.9 0 toxin C8UFQ2_ECO1A Putative type II secretion protein GspE OS=Escherichia coli O111:H- (strain 11128 / EHEC)\nB7LGA7_ECO55 General secretion pathway protein E OS=Escherichia coli (strain 55989 / EAEC) 0 1 Vibrio cholerae ToxT NP_230486 10198025;7565104;1400247;1352761 Vibrio cholerae The Vibrio cholerae ToxT regulon includes the genes encoding cholera toxin (CT) and the toxin-coregulated pilus (TCP) which are the major virulence factors required for causing cholera disease and colonizing the upper small intestine of the host respectively. PF12833.2 0 toxin B5Z1K1_ECO5E Putative transcription regulator OS=Escherichia coli O157:H7 (strain EC4115 / EHEC)\nC6UXV9_ECO5T Putative AraC-type regulatory protein encoded in prophage CP-933H OS=Escherichia coli O157:H7 (strain TW14359 / EHEC)\nB5QZZ1_SALEP AraC family regulatory protein OS=Salmonella enteritidis PT4 (strain P125109) 3GBG 1 1 Vibrio cholerae ToxR NP_230468 10198025;7565104;1400247;1560773 Vibrio cholerae It activates the expression of toxT resulting ultimately in the production of virulence factors such as cholera toxin and TCP. PF00041.16;PF10462.4;PF12561.3;PF12561.3 0 toxin C6V3C3_ECO5T Putative uncharacterized protein tagA OS=Escherichia coli O157:H7 (strain TW14359 / EHEC)\nB5YPK5_ECO5E Putative uncharacterized protein OS=Escherichia coli O157:H7 (strain EC4115 / EHEC)\nA0KGX4_AERHH Putative metalloprotease OS=Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / NCIB 9240) 0 1 Vibrio cholerae ToxS AAF94144 7836309 Vibrio cholerae It is a protein involved in regulation of Tcp pilus production in Vibrio cholerae. PB003806.1 1 toxin "Q5CQ58_CRYPI Putative uncharacterized protein OS=Cryptosporidium parvum (strain Iowa II)\nQ5CU64_CRYPI Histone transcription regulator (HIR1)-like WD40 repeat protein OS=Cryptosporidium parvum (strain Iowa II)\nQ5CT00_CRYPI Predicted secreted protein, signal peptide OS=Cryptosporidium parvum (strain Iowa II)" 0 1 Vibrio cholerae aphA YP_002820981 10048021 Vibrio cholerae aphA (activator of tcpP and tcpH expression) is required for the transcription of the tcpPH operon. PF03551.9;PF01136.14;PF10400.4 0 activator protein "C9YQU6_CLODR Transcriptional regulator, padr-like family OS=Clostridium difficile (strain R20291)\nC9XQS8_CLODC Transcriptional regulator, padr-like family OS=Clostridium difficile (strain CD196)\nQ17ZV3_CLOD6 Transcriptional regulator, PadR family OS=Clostridium difficile (strain 630)" 1YG2 1 1 Vibrio cholerae Ace NP_231102 8389476 Vibrio cholerae Produces fluid accumulation when measured using in vitro models and exhibits sequence homology to coat protein genes very likely to be the coat proteins of CTX. PF10734.4 0 toxin Q5CS02_CRYPI Leucine-rich repeat protein OS=Cryptosporidium parvum (strain Iowa II)\nSYFA_AERHH Phenylalanine--tRNA ligase alpha subunit OS=Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / NCIB 9240) 0 1 Vibrio cholerae zot NP_231101 8389476 Vibrio cholerae Increases the permeability of the small intestinal mucosa by affects the structure of the tight junctions that bind mucosal cells together and preserve the integrity of the mucosal membrane. PF05707.7 0 toxin No Homolog Found 0 0 Vibrio parahaemolyticus ctxA YP_004937111 22099121 Vibrio parahaemolyticus Causes severe disruption of intestinal cell function leading to the watery secretory diarrhea characteristic of cholera. PF12676.2;PF01375.12 0 toxin "Q5CXE1_CRYPI Secreted protein with signal peptide, fringe-like glycosyltransferase domain and a WcaK like glycosyltransferase domain (Fragment) OS=Cryptosporidium parvum (strain Iowa II)" 0 1 Vibrio parahaemolyticus TDH ADK74761 19873746;20847516 Vibrio parahaemolyticus Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture by mechanisms not clearly defined. PF03347.8 0 toxin A1JQ18_YERE8 Putative amino acid-binding protein OS=Yersinia enterocolitica serotype O:8 / biotype 1B (strain 8081) 0 1 Vibrio parahaemolyticus TRH AAX19064 19873746;20847516 Vibrio parahaemolyticus Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture by mechanisms not clearly defined. PF03347.8 0 toxin B5R446_SALEP Membrane-bound lytic murein transglycosylase d OS=Salmonella enteritidis PT4 (strain P125109)\nE1W8C6_SALTS Membrane-bound lytic murein transglycosylase d OS=Salmonella typhimurium (strain SL1344)\nF5ZM39_SALTU Membrane-bound lytic murein transglycosylase D OS=Salmonella typhimurium (strain ATCC 68169 / UK-1)\nQ83MN0_SHIFL Transcriptional regulator for nitrite reductase (Cytochrome c552) OS=Shigella flexneri 0 1 Vibrio parahaemolyticus VP1680 NP_798059 16428750 Vibrio parahaemolyticus VP1680 plays a key role in cytotoxicity to eukaryotic cells. No pfam domain found 0 toxin Q31Y17_SHIBS tRNA(Met) cytidine acetyltransferase TmcA OS=Shigella boydii serotype 4 (strain Sb227)\nB7UGM4_ECO27 tRNA(Met) cytidine acetyltransferase TmcA OS=Escherichia coli O127:H6 (strain E2348/69 / EPEC)\nD3H2W7_ECO44 tRNA(Met) cytidine acetyltransferase TmcA OS=Escherichia coli O44:H18 (strain 042 / EAEC)\nB5Z011_ECO5E tRNA(Met) cytidine acetyltransferase TmcA OS=Escherichia coli O157:H7 (strain EC4115 / EHEC) 0 1 Vibrio parahaemolyticus VP1686 BAC59949 16428750 Vibrio parahaemolyticus Adenylyltransferase involved in virulence by mediating the addition of adenosine 5'-monophosphate (AMP) to specific threonine residue of host Rho GTPases RhoA Rac and Cdc42. The resulting AMPylation prevents the interaction of Rho GTPases with downstream effectors thereby inhibiting actin assembly in infected cells PF02661.13 0 toxin C9YJ22_CLODR Fic family protein\nputative filamentation induced by cAMP protein OS=Clostridium difficile (strain R20291)\nC9XKT3_CLODC Fic family protein\nputative filamentation induced by cAMP protein OS=Clostridium difficile (strain CD196)\nA0KKL0_AERHH NAD-glutamate dehydrogenase OS=Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / NCIB 9240) 0 1 Vibrio parahaemolyticus VPA450 B5G6G5 16428750 Vibrio parahaemolyticus It plays a key role in cytotoxicity to eukaryotic cells. PF00594.15;PF00008.22;PF00089.21 0 toxin "A0KNG8_AERHH Tonin OS=Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / NCIB 9240)\nQ5CXK9_CRYPI Extacellular protein with a signal peptide, clostripain like caspase/hemoglobinase domain, notch domain and 2 EGF domains OS=Cryptosporidium parvum (strain Iowa II)\nQ5CQ18_CRYPI CpTSP7\nextracellular membrane associated protein with a signal peptide followed by 2 TSP1 repeats, an EGF domain and a transmembrane region OS=Cryptosporidium parvum (strain Iowa II) " 0 1 Vibrio parahaemolyticus VopA/P AAT08443 15501799;15459200 Vibrio parahaemolyticus It inhibits MAPK signaling using a novel mechanism. This effector acetylates a conserved lysine located in the catalytic loop of all kinases that plays a critical role in the binding of the ?-phosphate of ATP. Modification of this lysine by acetylation inhibits the binding of ATP but not ADP to the MAPK kinase resulting in an inactivate kinase. PF03421.11;PF06297.9 0 toxin A1JUC5_YERE8 Type III secretion system effector protein(Putative targeted effector protein) OS=Yersinia enterocolitica serotype O:8 / biotype 1B (strain 8081)\nE1WAB0_SALTS Type III secretion system effector protein-regulator of Salmonella-induced inflammatory response OS=Salmonella typhimurium (strain SL1344)\nF5ZV79_SALTU Secreted effector protein OS=Salmonella typhimurium (strain ATCC 68169 / UK-1) 0 1 Vibrio parahaemolyticus VopC BAH15044 22092817 Vibrio parahaemolyticus VopC promotes invasion by activating Rac and CDC42 by deamidation of Glutamine 61. PF05785.7 0 invasion protein A1JN83_YERE8 Putative uncharacterized protein OS=Yersinia enterocolitica serotype O:8 / biotype 1B (strain 8081) 0 1 Vibrio parahaemolyticus VopV AAB02642 22018240 Vibrio parahaemolyticus VopV an F-actin-binding type III secretion effector is required for Vibrio parahaemolyticus-induced enterotoxicity. PF13439.1;PF13692.1;PF01522.16 0 adhesin A0KQV2_AERHH WavL OS=Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / NCIB 9240)\nC8UGZ9_ECO1A Predicted polysaccharide deacetylase lipoprotein OS=Escherichia coli O111:H- (strain 11128 / EHEC)\nB7LGJ2_ECO55 Putative exported polysaccharide deacetylase OS=Escherichia coli (strain 55989 / EAEC)\nB7LGJ2_ECO55 Putative exported polysaccharide deacetylase OS=Escherichia coli (strain 55989 / EAEC) 0 1 Vibrio parahaemolyticus VCC AAD20592 19907657 Vibrio parahaemolyticus Vibrio cholerae cytolysin (VCC) is an important pore-forming toxin and exhibits specificity for membranes containing cholesterol and ceramides and contains a prodomain that is required for folding and must be cleaved to produce mature toxin. PF08453.5;PF08909.6;PF01752.12;PF04151.10 0 toxin A0KFM4_AERHH Collagenase family OS=Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / NCIB 9240)\nA0KGK2_AERHH Elastase OS=Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / NCIB 9240)\nB7UMR4_ECO27 Predicted capsid scaffolding protein OS=Escherichia coli O127:H6 (strain E2348/69 / EPEC)\nF5ZNX4_SALTU Putative integrase OS=Salmonella typhimurium (strain ATCC 68169 / UK-1) 0 1 Vibrio parahaemolyticus VopA AAT08443 20847516 Vibrio parahaemolyticus VopA inhibits MAPK signaling using a novel mechanism. This effector acetylates a conserved lysine located in the catalytic loop of all kinases that plays a critical role in the binding of the ?-phosphate of ATP. Modification of this lysine by acetylation inhibits the binding of ATP but not ADP to the MAPK kinase resulting in an inactivate kinase. PF03421.11;PF06297.9 0 toxin A1JUC5_YERE8 Type III secretion system effector protein (Putative targeted effector protein) OS=Yersinia enterocolitica serotype O:8 / biotype 1B (strain 8081)\nE1WAB0_SALTS Type III secretion system effector protein-regulator of Salmonella-induced inflammatory response OS=Salmonella typhimurium (strain SL1344)\nF5ZV79_SALTU Secreted effector protein OS=Salmonella typhimurium (strain ATCC 68169 / UK-1) 0 1 Vibrio parahaemolyticus VopT NP_001137455 20847516 Vibrio parahaemolyticus VopT is a ADP-ribosyltransferase effector protein secreted via the T3SS2 VopT ADP-ribosylates Ras both in vivo and in vitro. VopT shows approximately 45% and 44% identity with the ADP-ribosyltransferase (ADPRT) domain of ExoT and ExoS respectively which are two T3SS-secreted effectors of Pseudomonas aeruginosa. PF07383.7;PF00093.13;PF00093.13 0 toxin E6RWF2_CAMJS Pseudouridine synthase OS=Campylobacter jejuni subsp. jejuni (strain S3)\nA8FLD7_CAMJ8 Pseudouridine synthase OS=Campylobacter jejuni subsp. jejuni serotype O:6 (strain 81116 / NCTC11828)\nA1VZ63_CAMJJ Pseudouridine synthase OS=Campylobacter jejuni subsp. jejuni serotype O:23/36 (strain 81-176) 0 1 Aeromonas hydrophila VIP-2 2110196A 19880608 Aeromonas hydrophila Encoding an accessory virulence factor neuraminidase (nanH). Naminidase is secreted and converts oligosaccharides by cleavage of sialic acid. The reaction results in a large number of ganglioside GM1-like molecules on host cell surfaces which serve as binding sites for the cholera toxin. But this process in not absolutely required for the action of cholera toxin. PF02793.17;PF00002.19 0 toxin No Homolog Found 2X57 1 0 Aeromonas hydrophila VasH ABG57145 18037263;19880608 Aeromonas hydrophila It helps in regulation of transcription ATP binding DNA bindingnucleoside-triphosphatase activity and transcription factor binding. PF00158.21;PF02954.14 0 toxin C3NYA3_VIBCJ Sigma-54 dependent transcriptional regulator OS=Vibrio cholerae serotype O1 (strain MJ-1236)\nC3LUE1_VIBCM Sigma-54 dependent transcriptional regulator OS ==Vibrio cholerae serotype O1 (strainM66-2)\nA5F1D0_VIBC3 Sigma-54 dependent transcriptional regulator OS=Vibrio cholerae serotype O1 (strain ATCC 39541 / Ogawa 395 / O395)\nC6USX6_ECO5T Predicted DNA-binding transcriptional regulator OS=Escherichia coli O157:H7 (strain TW14359 / EHEC) 0 1 Aeromonas hydrophila VgrG1 AAR09145 19880608 Aeromonas hydrophila It induces host cell toxicity by ADP ribosylation of actin. PF04717.7;PF06890.7;PF13296.1;PF10106.4 0 toxin C3NYJ1_VIBCJ VgrG protein OS=Vibrio cholerae serotype O1(strain MJ-1236)\nC3LU47_VIBCM VgrG protein OS=Vibrio cholerae serotype O1 (strain M66-2)\nA5F1M5_VIBC3 VgrG protein OS=Vibrio cholerae serotype O1 (strain ATCC 39541 / Ogawa 395 / O395) 0 1 Rotavirus VP7 YP_392513 11718073;16191270 Rotavirus Outer capsid protein involved in attachment and possibly entry into the host epithelial cell. It is subsequently lost together with VP4 following virus entry into the host cell. The outer layer contains 780 copies of VP7 grouped as 260 trimers. Rotavirus attachment and entry into the host cell probably involves multiple sequential contacts between the outer capsid proteins VP4 and VP7 and the cell receptors. In integrin-dependent strains VP7 seems to essentially target the integrin heterodimers ITGAX/ITGB2 and ITGA5/ITGB3 at a postbinding stage once the initial attachment by VP4 has been achieved . PF00434.13;PF09949.4 0 surface protein No Homolog Found 2KVL 1 0 Rotavirus RVA_s9gp1  YP_002302222 17059839 Rotavirus It is an outer capsid protein involved in attachment and possibly entry into the host epithelial cell. PF00434.1 0 surface protein No Homolog Found 0 0 Rotavirus ADRSJV19_s9gp1 YP_392498 18796732 Rotavirus It has RNA-directed RNA polymerase activity and RNA binding activity. PF05868.6 0 surface protein No Homolog Found 0 0 Rotavirus G1P[8] ADK55701 20441801;21256248 Rotavirus  It is the viral hemagglutinin and an important target of neutralizing antibodies. In sialic acid-dependent strains it binds to host cell sialic acid most probably a ganglioside providing the initial contact PF00426.1 0 surface protein No Homolog Found 0 0 Rotavirus VP4 CAA55958 19936611 ;19046475 Rotavirus Acts as a membrane permeabilization protein that mediates release of viral particles from endosomal compartments into the cytoplasm PF00426.13;PF10119.4 0 surface protein No Homolog Found 0 0 Rotavirus NSP4 YP_002302223 10456791 Rotavirus Involved in virus morphogenesis. Functions as a receptor for the immature double-layered inner capsid particle (ICP) which transiently buds into the lumen of the rough endoplasmic reticulum during viral maturation. NSP4 is probably released from infected enterocytes in a soluble form capable of diffusing within the intestinal lumen and interacting with the plasma membrane receptors on neighboring epithelial cells. Possible receptors for NSP4 are alpha-1/beta-1 and alpha-2/beta-1 integrin heterodimers . PF01452.11;PF13974.1 0 glycoprotein No Homolog Found 3MIW 1 0 Clostridium difficile TcdA CAB60776 15831824;18480324;17517880 Clostridium difficile Transfer the glucose moiety from UDP-glucose to members of the Rho family of small GTPase. PF12918.2 0 toxin No Homolog Found 2QJ6 1 0 Clostridium difficile TcdB ABI93817 15831824;18480324;17517880 Clostridium difficile Transfer the glucose moiety from UDP-glucose to members of the Rho family of small GTPase. No pfam domain found 0 toxin No Homolog Found 3PEE 1 0 Clostridium difficile Cwp84 YP_001089300 21784932;17693508 Clostridium difficile Cwp84 as been shown to degrade some proteins of the extracellular matrix and play a role in the maturation of the precursor of the S-layer proteins. PF00112.18;PF04122.7 0 cysteine protease "A3FQK7_CRYPI Preprocathepsin c, putative OS=Cryptosporidium parvum (strain Iowa II)\nA0KKA3_AERHH Nuclease OS=Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / NCIB 9240)\nQ5CWJ0_CRYPI Cryptopain-cysteine proteinase secreted, possible transmembrane domain near N-terminus OS=Cryptosporidium parvum (strain Iowa II)" 0 1 Clostridium difficile C253 AAG28425 2808681 Clostridium difficile It adheres mainly to the basolateral surface of differentiated and undifferentiated polarized Caco-2 cells and increases pathogenesis. PF04122.7 0 surface protein A8FK77_CAMJ8 Putative uncharacterized protein OS=Campylobacter jejuni subsp. jejuni serotype O:6 (strain 81116 / NCTC 11828)\nE1WJ55_SALTS GTPase Era OS=Salmonella typhimurium (strain SL1344)\nF5ZTF0_SALTU GTPase Era OS=Salmonella typhimurium (strain ATCC 68169 / UK-1) 0 1 Clostridium difficile CDTa AAF81760 19692332 Clostridium difficile Mono-ADP-ribosylate Arg177 of all G-actin isoforms including -actin of skeletal muscle. PF03496.9 0 toxin No Homolog Found 2WN5 1 0 Clostridium difficile CDTb AAF81761 19692332 Clostridium difficile Mono-ADP-ribosylate Arg177 of all G-actin isoforms including -actin of skeletal muscle. PF07691.7;PF03495.9 0 toxin No Homolog Found 0 0 Clostridium difficile PrsW EHJ34828 21628514 Clostridium difficile PrsW is required for colonization resistance to antimicrobial peptides and expression of extracytoplasmic function ? factors in Clostridium difficile. PF13367.1;PF01699.19 0 serine protease Q5CTC6_CRYPI Putative uncharacterized protein OS=Cryptosporidium parvum (strain Iowa II) 0